DESCRIPTION:

Inflammatory cytokines significantly downregulated (p < 0.05) in peripheral blood mononuclear cells (PBMC) specimens from SARS-CoV2 patients compared to healthy donors. Genes were taken from starred genes in Figure 4B and which have value = "Down" in "Tag" column of the PBMC DEGs tab of Supplementary File 1. This tab is also the source of the values, which are log2 fold change, and the gene IDs, which were entered as base Ensemble IDs.

LABEL:

InflammatoryCytokines_Down_in_Covid19_PBMC

SCORE TYPE:

Effect

DATE ADDED:

2021-06-28

DATE UPDATED:

2021-06-28

SPECIES:

AUTHORS:

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen

TITLE:

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

JOURNAL:

Emerging microbes & infections Dec 2020, Vol 9, pp. 761-770

ABSTRACT:

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response. PUBMED: 32228226
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