DESCRIPTION:

545 genes differentially expressed in human subjects in the opioid abuse cohort, some of which are overlapping with genes previously shown to be differentially expressed in relation to cocaine use. The opioid use and control cohorts were "matched in terms of gender, race, age, brain pH, and RIN [RNA integrity number]." Post-mortem ventral midbrain specimens were collected and analyzed via RNA-seq. The full raw sequencing data can be found at NCBI Sequence Read Archive with accession number PRJNA492904. Data taken from Supplementary Table S2. Values presented are p-adjusted values.

LABEL:

Human opioid differentially expressed

SCORE TYPE:

Q-Value

DATE ADDED:

2021-06-10

DATE UPDATED:

2022-05-24

SPECIES:

AUTHORS:

Manal H Saad, Matthew Rumschlag, Michael H Guerra, Candace L Savonen, Alaina M Jaster, Philip D Olson, Adnan Alazizi, Francesca Luca, Roger Pique-Regi, Carl J Schmidt, Michael J Bannon

TITLE:

Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusers.

JOURNAL:

Scientific reports 02 2019, Vol 9, pp. 1534

ABSTRACT:

Opioid abuse is now the most common cause of accidental death in the US. Although opioids and most other drugs of abuse acutely increase signaling mediated by midbrain dopamine (DA)-synthesizing neurons, little is known about long-lasting changes in DA cells that may contribute to continued opioid abuse, craving, and relapse. A better understanding of the molecular and cellular bases of opioid abuse could lead to advancements in therapeutics. This study comprises, to our knowledge, the first unbiased examination of genome-wide changes in midbrain gene expression associated with human opioid abuse. Our analyses identified differentially expressed genes and distinct gene networks associated with opioid abuse, specific genes with predictive capability for subject assignment to the opioid abuse cohort, and genes most similarly affected in chronic opioid and cocaine abusers. We also identified differentially expressed long noncoding RNAs capable of regulating known drug-responsive protein-coding genes. Opioid-regulated genes identified in this study warrant further investigation as potential biomarkers and/or therapeutic targets for human substance abuse. PUBMED: 30733491
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