DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Anorexia nervosa. The EFO term anorexia nervosa was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: anorexia nervosa

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

V Boraska, CS Franklin, JA Floyd, LM Thornton, LM Huckins, L Southam, NW Rayner, I Tachmazidou, KL Klump, J Treasure, CM Lewis, U Schmidt, F Tozzi, K Kiezebrink, J Hebebrand, P Gorwood, RA Adan, MJ Kas, A Favaro, P Santonastaso, F Fernández-Aranda, M Gratacos, F Rybakowski, M Dmitrzak-Weglarz, J Kaprio, A Keski-Rahkonen, A Raevuori, EF Van Furth, MC Slof-Op 't Landt, JI Hudson, T Reichborn-Kjennerud, GP Knudsen, P Monteleone, AS Kaplan, A Karwautz, H Hakonarson, WH Berrettini, Y Guo, D Li, NJ Schork, G Komaki, T Ando, H Inoko, T Esko, K Fischer, K Männik, A Metspalu, JH Baker, RD Cone, J Dackor, JE DeSocio, CE Hilliard, JK O'Toole, J Pantel, JP Szatkiewicz, C Taico, S Zerwas, SE Trace, OS Davis, S Helder, K Bühren, R Burghardt, M de Zwaan, K Egberts, S Ehrlich, B Herpertz-Dahlmann, W Herzog, H Imgart, A Scherag, S Scherag, S Zipfel, C Boni, N Ramoz, A Versini, MK Brandys, UN Danner, C de Kovel, J Hendriks, BP Koeleman, RA Ophoff, E Strengman, AA van Elburg, A Bruson, M Clementi, D Degortes, M Forzan, E Tenconi, E Docampo, G Escaramís, S Jiménez-Murcia, J Lissowska, A Rajewski, N Szeszenia-Dabrowska, A Slopien, J Hauser, L Karhunen, I Meulenbelt, PE Slagboom, A Tortorella, M Maj, G Dedoussis, D Dikeos, F Gonidakis, K Tziouvas, A Tsitsika, H Papezova, L Slachtova, D Martaskova, JL Kennedy, RD Levitan, Z Yilmaz, J Huemer, D Koubek, E Merl, G Wagner, P Lichtenstein, G Breen, S Cohen-Woods, A Farmer, P McGuffin, S Cichon, I Giegling, S Herms, D Rujescu, S Schreiber, HE Wichmann, C Dina, R Sladek, G Gambaro, N Soranzo, A Julia, S Marsal, R Rabionet, V Gaborieau, DM Dick, A Palotie, S Ripatti, E Widén, OA Andreassen, T Espeseth, A Lundervold, I Reinvang, VM Steen, S Le Hellard, M Mattingsdal, I Ntalla, V Bencko, L Foretova, V Janout, M Navratilova, S Gallinger, D Pinto, SW Scherer, H Aschauer, L Carlberg, A Schosser, L Alfredsson, B Ding, L Klareskog, L Padyukov, P Courtet, S Guillaume, I Jaussent, C Finan, G Kalsi, M Roberts, DW Logan, L Peltonen, GR Ritchie, JC Barrett, X Estivill, A Hinney, PF Sullivan, DA Collier, E Zeggini, CM Bulik

TITLE:

A genome-wide association study of anorexia nervosa.

JOURNAL:

Molecular psychiatry Oct 2014, Vol 19, pp. 1085-94

ABSTRACT:

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field. PUBMED: 24514567
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