GeneSet Information

Tier III GS137563 • Differentially expressed genes between selected High Anxiety-related Behavior (HAB) and (Low Anxiety-related Behavior) LAB mice in all analyzed brain regions.

DESCRIPTION:

Microarrays were used to investigate the gene expression profiles of different brain regions within the limbic system of mice which were selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, and also show signs of comorbid depression-like behavior. This gene set contains significantly differentially expressed genes between HAB and LAB mice. Brain regions include the hypothalamic paraventricular nucleus (PVN), the supraoptic nucleus (SON), the basolateral (BLA) and central (CeA) amygdala, and the cingulate cortex (Cg), as well as the nucleus accumbens (NAc) and dentate gyrus (DG). Statistics reported as p-value.

LABEL:

Dif Exp -Anxiety-several regions

SCORE TYPE:

P-Value

DATE ADDED:

None

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Ptz B, Ahmad N, Bunck M, Graf C, Widner R, Khne C, Panhuysen M, Hambsch B, Rieder G, Reinheckel T, Peters C, Holsboer F, Landgraf R, Deussing JM

TITLE:

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice.

JOURNAL:

PloS one None 2011, Vol 6, pp. e23604

ABSTRACT:

Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety". We used microarrays to investigate the gene expression profiles of different brain regions within the limbic system of mice which were selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, and also show signs of comorbid depression-like behavior. We identified and confirmed sex-independent differences in the basal expression of 13 candidate genes, using tissue from the entire brain, including coronin 7 (Coro7), cathepsin B (Ctsb), muscleblind-like 1 (Mbnl1), metallothionein 1 (Mt1), solute carrier family 25 member 17 (Slc25a17), tribbles homolog 2 (Trib2), zinc finger protein 672 (Zfp672), syntaxin 3 (Stx3), ATP-binding cassette, sub-family A member 2 (Abca2), ectonucleotide pyrophosphatase/phosphodiesterase 5 (Enpp5), high mobility group nucleosomal binding domain 3 (Hmgn3) and pyruvate dehydrogenase beta (Pdhb). Additionally, we confirmed brain region-specific differences in the expression of synaptotagmin 4 (Syt4).Our identification of about 90 polymorphisms in Ctsb suggested that this gene might play a critical role in shaping our mouse model\'s behavioral endophenotypes. Indeed, the assessment of anxiety-related and depression-like behaviors of Ctsb knock-out mice revealed an increase in depression-like behavior in females. Altogether, our results suggest that Ctsb has significant effects on emotionality, irrespective of the tested mouse strain, making it a promising target for future pharmacotherapy. PUBMED: 21897848
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Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Supraoptic Nucleus (D013495)
Family (D005190)
Forecasting (D005544)
Zinc Fingers (D016335)
Synaptotagmins (D050857)
Play and Playthings (D010988)
Behavior (D001519)
Drug Therapy (D004358)
Mice (D051379)
Gene Expression Profiling (D020869)
Paraventricular Hypothalamic Nucleus (D010286)
Statistics (D020500)
Dentate Gyrus (D018891)
Mice, Knockout (D018345)
Role (D012380)
Amygdala (D000679)
Tissues (D014024)
Nucleus Accumbens (D009714)
Oxidoreductases (D010088)
Cyclic Nucleotide Phosphodiesterases, Type 5 (D054706)
Endophenotypes (D058068)
Identification (Psychology) (D007062)
Cathepsin B (D002401)
Cathepsins (D002403)
Qa-SNARE Proteins (D050765)
Fingers (D005385)
Gyrus Cinguli (D006179)
Zinc (D015032)
Pyruvic Acid (D019289)
Set (Psychology) (D012718)
Anxiety (D001007)
Metallothionein (D008668)
Limbic System (D008032)
amygdala (MA:0000887)
cingulate cortex (MA:0000904)
brain (MA:0000168)
supraoptic nucleus (MA:0000849)
dentate gyrus (MA:0000190)
nucleus (GO:0005634)
binding (GO:0005488)
gene expression (GO:0010467)
behavior (GO:0007610)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351