DESCRIPTION:

QTL associated with epistatic circling B C57L/J. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (136483111)

LABEL:

QTL-Eclb-Mouse-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:95279

AUTHORS:

Cryns K, van Alphen AM, van Spaendonck MP, van de Heyning PH, Timmermans JP, de Zeeuw CI, van Camp G

TITLE:

Circling behavior in the Ecl mouse is caused by lateral semicircular canal defects.

JOURNAL:

The Journal of comparative neurology Jan 2004, Vol 468, pp. 587-95

ABSTRACT:

The epistatic circler mouse (Ecl mouse) is a preexisting mutant, which displays a circling phenotype and hyperactivity. It has been shown that the circling phenotype in this mutant results from a complex inheritance pattern, but the vestibular pathology has not been analyzed. The present study deals with the morphological and functional basis responsible for the circling behavior in the Ecl mouse. Morphological examination of the inner ears revealed a bilateral malformation of the horizontal (lateral) semicircular canal and duct. No cochlear abnormalities were detected, and auditory brainstem response (ABR) measurements indicated that the auditory system is not affected. Investigation of the vestibuloocular reflex (VOR) in Ecl mice showed that their horizontal VOR on stimulation is virtually absent, which correlates with the morphological findings. PUBMED: 14689488
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