GeneSet Details :: GeneWeaver

Tier II GS135745 • experimental allergic encephalomyelitis susceptibility11 (Eae11, Published QTL Chr 16)

DESCRIPTION:

QTL associated with experimental allergic encephalomyelitis susceptibility11. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (70765248)

LABEL:

QTL-Eae11-Mouse-Chr 16

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1345097

AUTHORS:

Lindvall T, Nandakumar KS, Yousefi K, Holmdahl R, Andersson A

TITLE:

An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes.

JOURNAL:

Journal of neuroimmunology Jun 2011, Vol 235, pp. 40-7

ABSTRACT:

A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4+ T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules. PUBMED: 21543122
Find other GeneSets from this publication

Annotation Information

No sequence read archive data associated with this GeneSet.

T-Lymphocytes (D013601)

Mice, Congenic (D020297)

Mice (D051379)

Chromosomes (D002875)

Central Nervous System (D002490)

Chromosomes, Human, Pair 16 (D002885)

Flow Cytometry (D005434)

Nervous System (D009420)

Encephalomyelitis (D004679)

Cells (D002477)

Encephalomyelitis, Autoimmune, Experimental (D004681)

B-Lymphocytes (D001402)

Arthritis (D001168)

central nervous system (MA:0000167)

nervous system (MA:0000016)

CNS inflammation (MP:0006082)

nervous (MP:0008912)

arthritis (MP:0002993)

chromosome (GO:0005694)

QTL map (EDAM_data:1860)

Gene List • 244 Genes

Uploaded As	Gene Symbol Gene Symbol Entrez Ensembl Gene UniGene MGI FlyBase WormBase RGD ZFIN	Homology	Score	Priority	LinkOuts	Emphasis

GeneSet Information

Tier II GS135745 • experimental allergic encephalomyelitis susceptibility11 (Eae11, Published QTL Chr 16)

Annotation Information

Gene List • 244 Genes

Manage GeneSets

Analyze GeneSets

Manage Accounts

GeneWeaver Links

Policies

What seems to be the problem?

Description:

Name:

Email:

GeneSet Information

Tier II GS135745 • experimental allergic encephalomyelitis susceptibility11 (Eae11, Published QTL Chr 16)

Annotation Information

Gene List • 244 Genes

Add Selected GeneSets to Project(s)

The following GeneSet(s) will be added:

New Project Name

New Project Name:

Comments:

Share Selected GeneSets with Group(s)

The following GeneSet(s) will be added:

Delete GeneSet

Are you sure that you want to delete GeneSet ? This will permanently remove this GeneSet and may produce concurrency issues in projects.

Request Curation for Geneset

A request will be submitted to the Gene Weaver core curators for the following geneset:

Notes for the Curator (required):

Select Type of Data Export

GeneWeaver offers several export options. The 'GeneSet Complete' format can be used as an upload file in GeneWeaver's batch upload function.

Manage GeneSets

Analyze GeneSets

Manage Accounts

GeneWeaver Links

Policies