GeneSet Information

Tier II GS135712 • diabesity 2 (Dbsty2, Published QTL Chr 5)

DESCRIPTION:

QTL associated with diabesity 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (93726231)

LABEL:

QTL-Dbsty2-Mouse-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2149844

AUTHORS:

Kaput J, Klein KG, Reyes EJ, Kibbe WA, Cooney CA, Jovanovic B, Visek WJ, Wolff GL

TITLE:

Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.

JOURNAL:

Physiological genomics Aug 2004, Vol 18, pp. 316-24

ABSTRACT:

The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes. PUBMED: 15306695
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Annotation Information

No sequence read archive data associated with this GeneSet.


Caloric Restriction (D031204)
Incidence (D015994)
Insulin Resistance (D007333)
Quantitative Trait Loci (D040641)
Societies (D012952)
Liver (D008099)
Genotype (D005838)
Insulin (D007328)
Inflammation (D007249)
Dyslipidemias (D050171)
Obesity (D009765)
Identification (Psychology) (D007062)
Hyperinsulinism (D006946)
Hyperglycemia (D006943)
Diet (D004032)
obese (MP:0001261)
hyperglycemia (MP:0001559)
insulin resistance (MP:0005331)
increased circulating insulin level (MP:0002079)
abnormal inflammatory response (MP:0001845)
gene expression (GO:0010467)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351