GeneSet Information

Tier I GS128162 • Cingulated cortex Methamphetamine and reward

DESCRIPTION:

Table 4. Genes that are altered in the cingulated cortex in response to methamphetamine in Sprague-Dawley Rats, includes fold change ratio for maintenance/induction.

LABEL:

CingulatedCortex Methamphetamine

SCORE TYPE:

Correlation

DATE ADDED:

None

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Yang MH, Jung MS, Lee MJ, Yoo KH, Yook YJ, Park EY, Choi SH, Suh YJ, Kim KW, Park JH

TITLE:

Gene expression profiling of the rewarding effect caused by methamphetamine in the mesolimbic dopamine system.

JOURNAL:

Molecules and cells Aug 2008, Vol 26, pp. 121-30

ABSTRACT:

Methamphetamine, a commonly used addictive drug, is a powerful addictive stimulant that dramatically affects the CNS. Repeated METH administration leads to a rewarding effect in a state of addiction that includes sensitization, dependence, and other phenomena. It is well known that susceptibility to the development of addiction is influenced by sources of reinforcement, variable neuroadaptive mechanisms, and neurochemical changes that together lead to altered homeostasis of the brain reward system. These behavioral abnormalities reflect neuroadaptive changes in signal transduction function and cellular gene expression produced by repeated drug exposure. To provide a better understanding of addiction and the mechanism of the rewarding effect, it is important to identify related genes. In the present study, we performed gene expression profiling using microarray analysis in a reward effect animal model. We also investigated gene expression in four important regions of the brain, the nucleus accumbens, striatum, hippocampus, and cingulated cortex, and analyzed the data by two clustering methods. Genes related to signaling pathways including G-protein-coupled receptor-related pathways predominated among the identified genes. The genes identified in our study may contribute to the development of a gene modeling network for methamphetamine addiction. PUBMED: 18594179
Find other GeneSets from this publication

Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Homeostasis (D006706)
Animals (D000818)
Reinforcement (Psychology) (D012054)
Gene Expression Profiling (D020869)
Comprehension (D032882)
Methamphetamine (D008694)
Microarray Analysis (D046228)
Maintenance (D008283)
Models, Animal (D023421)
Dopamine (D004298)
Rats (D051381)
Nucleus Accumbens (D009714)
Affect (D000339)
Lead (D007854)
Methods (D008722)
Organization and Administration (D009934)
Genes, vif (D016341)
Reward (D012201)
Signal Transduction (D015398)
Rats, Sprague-Dawley (D017207)
Hippocampus (D006624)
Cluster Analysis (D016000)
striatum (MA:0000891)
brain (MA:0000168)
hippocampus (MA:0000191)
addiction (MP:0002555)
sensitization (GO:0046960)
transduction (GO:0009293)
nucleus (GO:0005634)
signal transduction (GO:0007165)
gene expression (GO:0010467)
signaling (GO:0023052)

Gene List • 15 Genes

Uploaded As Gene Symbol Homology Score Priority LinkOuts Emphasis  

Manage GeneSets

Analyze GeneSets

Manage Accounts

GeneWeaver Links

Policies


Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351