QTL associated with susceptibility to lung cancer 17. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (179526405)
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
QTL associated with bladder tumor susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (149007975)
Authors:
Higashi S, Murai T, Mori S, Kamoto T, Yoshitomi M, Arakawa Y, Makino S, Fukushima S, Yoshida O, Hiai H
QTL associated with weight gain in high growth mice 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (149007975)
QTL associated with "alcohol preference locus 5, male specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (180579319)
QTL associated with "alcohol preference locus 6, female specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (180579319)
QTL associated with circulating hormone level QTL 13. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (152683037)
QTL associated with erosive arthritis susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (162170578)
Authors:
Mountz JD, Yang P, Wu Q, Zhou J, Tousson A, Fitzgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, Hsu HC
QTL associated with orthodenticle homolog 2 (Drosophila) modifier 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (148684054)
Authors:
Hide T, Hatakeyama J, Kimura-Yoshida C, Tian E, Takeda N, Ushio Y, Shiroishi T, Aizawa S, Matsuo I
Ethanol induced LORR Chr# 2 rs13476399(28144658) with right flanking marker rs3713997(3151175) and left marker rs3679483 (179861211). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with proteoglycan induced arthritis 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (140921127)
Authors:
Otto JM, Cs-Szab G, Gallagher J, Velins S, Mikecz K, Buzs EI, Enders JT, Li Y, Olsen BR, Glant TT
QTL associated with spontaneous crescentic glomerulonephritis QTL 3. The confidence interval is Chr2:151693089-174372832 bp,+strand
Authors:
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
QTL associated with autoimmune ovarian dysgenesis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (162212535)
QTL associated with atherosclerotic lesion area 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (148505908)
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