Whole brain expression correlates of ethanol withdrawal in BXD RI mice based on phenotype data in the 1997 Buck et al manuscript. Expression correlates were generated using GeneNetwork.org
Microarray gene expression profiling results of rat-striatum after cocaine self-administration were used to identify co-regulation of certain mRNAs involved in cocaine-induced changes in circadian rhythmicity. This gene set comprises upregulated genes during the 7-day period of hourly cocaine self-infusion.
Authors:
Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR
Striatum Gene Expression Correlates for MORPH_NX measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The MORPH_NX measures Change in distance travelled last 15 min morphine-15 min naloxone under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for ZM_ACTIVITY measured in BXD RI Females & Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The ZM_ACTIVITY measures Zero Maze - Total Activity count; number of beam breaks under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMCNT165 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMCNT165 measures Morphine photocell counts minutes 150-165 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for HAND_4HOURS measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The HAND_4HOURS measures Handling induced convulsions 4 hrs after ethanol under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL for differences in cocaine responsiveness on Chr8 at D8MIt8 (53.66 Mbp , Build 37)
Description:
differences in cocaine responsiveness spans 28.66 - 78.66 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for chronic alcohol withdrawal severity on Chr8 at D8Mit25 (65.54 Mbp , Build 37)
Description:
chronic alcohol withdrawal severity spans 40.54 - 90.54 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for METH responses for body temperature on Chr8 at D8Ncvs43 (95.66 Mbp , Build 37)
Description:
METH responses for body temperature spans 70.66 - 120.66 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - Cocaine vs. Saline DNA microarray Change in gene expression Five rats were trained to self-administer cocaine infusions (1.5 mg / kg) during daily sessions. Once rats acquired cocaine self-administration (five consecutive sessions in which rats earned all 20 infusions that were available), cocaine infusions (1.5 mg / kg) were available in discrete 10-min trials 24-hr per day (4 trials / hr). Each discrete trial was initiated by the extension of the left lever into the chamber. Each response on this lever during a 10-minute discrete trial produced an infu Genespring 7.0 A gene was considered to be expressed if its signal intensity was a minimum of twice the background in at least four of the five replicates. Upregulated genes were defined as having an average expression ratio of >1.4, and the downregulated genes were defined as having an average expression ratio of <0.7. A gene was considered to be significantly regulated if the t-test p-value was < 0.05 with the false discovery rate (FDR) as the multiple testing correction. (NIF Method ID 182)
Authors:
Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR
Rats in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks. Additive QTL. LOD 2.9 Peak Marker: D16Mit2 spans 1-26804456. Strains were HAD1, LAD1.
Authors:
Foroud T, Bice P, Castelluccio P, Bo R, Miller L, Ritchotte A, Lumeng L, Li TK, Carr LG
Rats in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks. Additive QTL. Variance 2, LOD 3.2 Peak Marker: D16Mgh1 spans D16Mit2(4304396) - D16Rat60(64081533). Strains were HAD1, LAD1, HAD2 , LAD2
Authors:
Carr LG, Habegger K, Spence J, Ritchotte A, Liu L, Lumeng L, Li TK, Foroud T
Ethanol induced LORR Chr# 8 rs3666140 (44049661) with right flanking marker rs3661760(24557766) and left marker rs13479995 (116236688). This was mapped in 300 + (b6x129)F2 mice.
Ethanol Induced Ataxia Chr#8 rs3699406 (72486070) with right flanking marker rs6386110 (45897379) and left marker rs13479995(116236688). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with autoimmune extremity vasculitis in MRL mice 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (73811716)
Authors:
Yamada A, Miyazaki T, Lu LM, Ono M, Ito MR, Terada M, Mori S, Hata K, Nozaki Y, Nakatsuru S, Nakamura Y, Onji M, Nose M
QTL associated with P. chabaudi malaria resistance QTL 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (98606078)
Authors:
Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, Foote S, Gros P
QTL associated with circulating hormone level QTL 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (90920080)
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