Using a two-stage process, several genes were initially identified using microarray analyses of cerebellar tissue from ethanol-treated PKCgamma mutant and wild-type mice. This geneset consists of genes related to PKCgamma mutant expression changes due to chronic ethanol diet.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
This gene set comprises 17 ethanol-dependence genes that were downregulated in the PKC-gamma wild-type mice during the experiment. Background: Study shows that PKC-gamma wild-type mice develop tolerance to the sedative-hypnotic effects of ethanol after chronic ethanol treatment but mutant mice do not, making these genotypes a suitable model for identifying changes in gene expression related developing tolerance toward ethanol.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
Cerebellum Gene Expression Correlates for VOCA_THRESHOLD measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VOCA_THRESHOLD measures Vocalization Threshold - shock intensity (mA) under the domain Stress Vocalization. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ
alcohol preference 7 spans 13.47 - 63.47 Mbp (NCBI Build 37) on Chr7. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bachmanov AA, Reed DR, Li X, Li S, Beauchamp GK, Tordoff MG
Ethanol Induced Hypothermia Chr# 7 rs13479153(25722935) with right flanking marker rs3700068(4187548) and left marker rs3716088(140189839). This was mapped in 300 + (b6x129)F2 mice.
BECs at LORR Recovery Chr# 7 rs13479145(19988355) with right flanking marker rs6384973(5036805) and left marker rs3663313 (63388111). This was mapped in 300 + (b6x129)F2 mice.
Average rotarod training latency Chr# 7 mCV23423763(68111945) with right flanking marker rs3700068(4187548) and left marker rs3663988(146505067). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with Avp transcript abundance QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (4955366)
QTL associated with bronchial hyperresponsiveness 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37927844)
Authors:
De Sanctis GT, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Lander ES, Beier DR, Drazen JM
QTL associated with beta-carboline induced seizures 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34527929)
Authors:
Gershenfeld HK, Neumann PE, Li X, St Jean PL, Paul SM
QTL associated with Crhr1 transcript abundance QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (4955366)
QTL associated with experimental allergic encephalomyelitis susceptibility 12. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37365609)
Authors:
Butterfield RJ, Blankenhorn EP, Roper RJ, Zachary JF, Doerge RW, Sudweeks J, Rose J, Teuscher C
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