The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
Genes associated with Mus musculus that interact with the MeSH term 'pirinixic acid' (C006253). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Mus musculus that interact with the MeSH term 'sinefungin' (C006235). Incorporates data from 6366 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes with particular expression in the Anterior olfactory nucleus, dorsal part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterolateral visual area, layer 5. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Orbital area, medial part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Crus 2, granular layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Crus 2, molecular layer. Data represent fold expression difference in structure versus grey matter average expression.
Average rotarod training latency Chr# 5 rs13478110 (9741228) with right flanking marker rs13478092(3595407) and left marker rs3718776 (150393227). This was mapped in 300 + (b6x129)F2 mice.
Genes with particular expression in the Primary somatosensory area, trunk, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Entorhinal area, lateral part, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Infralimbic area. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Entorhinal area, lateral part, layer 3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Lateral visual area, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Entorhinal area, lateral part, layer 4. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Entorhinal area, lateral part, layer 5. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Dorsal auditory area, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Agranular insular area, posterior part, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Temporal association areas, layer 5. Data represent fold expression difference in structure versus grey matter average expression.
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