List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Triglycerides. The EFO term triglyceride measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JE Below, EJ Parra, ER Gamazon, J Torres, S Krithika, S Candille, Y Lu, A Manichakul, J Peralta-Romero, Q Duan, Y Li, AP Morris, O Gottesman, E Bottinger, XQ Wang, KD Taylor, YD Ida Chen, JI Rotter, SS Rich, RJ Loos, H Tang, NJ Cox, M Cruz, CL Hanis, A Valladares-Salgado
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Triglycerides. The EFO term triglyceride measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
S Kathiresan, O Melander, C Guiducci, A Surti, NP Burtt, MJ Rieder, GM Cooper, C Roos, BF Voight, AS Havulinna, B Wahlstrand, T Hedner, D Corella, ES Tai, JM Ordovas, G Berglund, E Vartiainen, P Jousilahti, B Hedblad, MR Taskinen, C Newton-Cheh, V Salomaa, L Peltonen, L Groop, DM Altshuler, M Orho-Melander
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Triglycerides. The EFO term triglyceride measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
CJ Willer, S Sanna, AU Jackson, A Scuteri, LL Bonnycastle, R Clarke, SC Heath, NJ Timpson, SS Najjar, HM Stringham, J Strait, WL Duren, A Maschio, F Busonero, A Mulas, G Albai, AJ Swift, MA Morken, N Narisu, D Bennett, S Parish, H Shen, P Galan, P Meneton, S Hercberg, D Zelenika, WM Chen, Y Li, LJ Scott, PA Scheet, J Sundvall, RM Watanabe, R Nagaraja, S Ebrahim, DA Lawlor, Y Ben-Shlomo, G Davey-Smith, AR Shuldiner, R Collins, RN Bergman, M Uda, J Tuomilehto, A Cao, FS Collins, E Lakatta, GM Lathrop, M Boehnke, D Schlessinger, KL Mohlke, GR Abecasis
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Liver enzyme levels (alanine transaminase). The EFO term serum alanine aminotransferase measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JC Chambers, W Zhang, J Sehmi, X Li, MN Wass, P Van der Harst, H Holm, S Sanna, M Kavousi, SE Baumeister, LJ Coin, G Deng, C Gieger, NL Heard-Costa, JJ Hottenga, B Kühnel, V Kumar, V Lagou, L Liang, J Luan, PM Vidal, I Mateo Leach, PF O'Reilly, JF Peden, N Rahmioglu, P Soininen, EK Speliotes, X Yuan, G Thorleifsson, BZ Alizadeh, LD Atwood, IB Borecki, MJ Brown, P Charoen, F Cucca, D Das, EJ de Geus, AL Dixon, A Döring, G Ehret, GI Eyjolfsson, M Farrall, NG Forouhi, N Friedrich, W Goessling, DF Gudbjartsson, TB Harris, AL Hartikainen, S Heath, GM Hirschfield, A Hofman, G Homuth, E Hyppönen, HL Janssen, T Johnson, AJ Kangas, IP Kema, JP Kühn, S Lai, M Lathrop, MM Lerch, Y Li, TJ Liang, JP Lin, RJ Loos, NG Martin, MF Moffatt, GW Montgomery, PB Munroe, K Musunuru, Y Nakamura, CJ O'Donnell, I Olafsson, BW Penninx, A Pouta, BP Prins, I Prokopenko, R Puls, A Ruokonen, MJ Savolainen, D Schlessinger, JN Schouten, U Seedorf, S Sen-Chowdhry, KA Siminovitch, JH Smit, TD Spector, W Tan, TM Teslovich, T Tukiainen, AG Uitterlinden, MM Van der Klauw, RS Vasan, C Wallace, H Wallaschofski, HE Wichmann, G Willemsen, P Würtz, C Xu, LM Yerges-Armstrong, GR Abecasis, KR Ahmadi, DI Boomsma, M Caulfield, WO Cookson, CM van Duijn, P Froguel, K Matsuda, MI McCarthy, C Meisinger, V Mooser, KH Pietiläinen, G Schumann, H Snieder, MJ Sternberg, RP Stolk, HC Thomas, U Thorsteinsdottir, M Uda, G Waeber, NJ Wareham, DM Waterworth, H Watkins, JB Whitfield, JC Witteman, BH Wolffenbuttel, CS Fox, M Ala-Korpela, K Stefansson, P Vollenweider, H Völzke, EE Schadt, J Scott, MR Järvelin, P Elliott, JS Kooner
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Liver enzyme levels (alkaline phosphatase). The EFO term alkaline phosphatase measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JC Chambers, W Zhang, J Sehmi, X Li, MN Wass, P Van der Harst, H Holm, S Sanna, M Kavousi, SE Baumeister, LJ Coin, G Deng, C Gieger, NL Heard-Costa, JJ Hottenga, B Kühnel, V Kumar, V Lagou, L Liang, J Luan, PM Vidal, I Mateo Leach, PF O'Reilly, JF Peden, N Rahmioglu, P Soininen, EK Speliotes, X Yuan, G Thorleifsson, BZ Alizadeh, LD Atwood, IB Borecki, MJ Brown, P Charoen, F Cucca, D Das, EJ de Geus, AL Dixon, A Döring, G Ehret, GI Eyjolfsson, M Farrall, NG Forouhi, N Friedrich, W Goessling, DF Gudbjartsson, TB Harris, AL Hartikainen, S Heath, GM Hirschfield, A Hofman, G Homuth, E Hyppönen, HL Janssen, T Johnson, AJ Kangas, IP Kema, JP Kühn, S Lai, M Lathrop, MM Lerch, Y Li, TJ Liang, JP Lin, RJ Loos, NG Martin, MF Moffatt, GW Montgomery, PB Munroe, K Musunuru, Y Nakamura, CJ O'Donnell, I Olafsson, BW Penninx, A Pouta, BP Prins, I Prokopenko, R Puls, A Ruokonen, MJ Savolainen, D Schlessinger, JN Schouten, U Seedorf, S Sen-Chowdhry, KA Siminovitch, JH Smit, TD Spector, W Tan, TM Teslovich, T Tukiainen, AG Uitterlinden, MM Van der Klauw, RS Vasan, C Wallace, H Wallaschofski, HE Wichmann, G Willemsen, P Würtz, C Xu, LM Yerges-Armstrong, GR Abecasis, KR Ahmadi, DI Boomsma, M Caulfield, WO Cookson, CM van Duijn, P Froguel, K Matsuda, MI McCarthy, C Meisinger, V Mooser, KH Pietiläinen, G Schumann, H Snieder, MJ Sternberg, RP Stolk, HC Thomas, U Thorsteinsdottir, M Uda, G Waeber, NJ Wareham, DM Waterworth, H Watkins, JB Whitfield, JC Witteman, BH Wolffenbuttel, CS Fox, M Ala-Korpela, K Stefansson, P Vollenweider, H Völzke, EE Schadt, J Scott, MR Järvelin, P Elliott, JS Kooner
GWAS: triglyceride measurement, high density lipoprotein cholesterol measurement
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was HDL Cholesterol - Triglycerides (HDLC-TG). The EFO term triglyceride measurement, high density lipoprotein cholesterol measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
AT Kraja, D Vaidya, JS Pankow, MO Goodarzi, TL Assimes, IJ Kullo, U Sovio, RA Mathias, YV Sun, N Franceschini, D Absher, G Li, Q Zhang, MF Feitosa, NL Glazer, T Haritunians, AL Hartikainen, JW Knowles, KE North, C Iribarren, B Kral, L Yanek, PF O'Reilly, MI McCarthy, C Jaquish, DJ Couper, A Chakravarti, BM Psaty, LC Becker, MA Province, E Boerwinkle, T Quertermous, L Palotie, MR Jarvelin, DM Becker, SL Kardia, JI Rotter, YD Chen, IB Borecki
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Triglycerides-Blood Pressure (TG-BP). The EFO term triglyceride measurement, blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
AT Kraja, D Vaidya, JS Pankow, MO Goodarzi, TL Assimes, IJ Kullo, U Sovio, RA Mathias, YV Sun, N Franceschini, D Absher, G Li, Q Zhang, MF Feitosa, NL Glazer, T Haritunians, AL Hartikainen, JW Knowles, KE North, C Iribarren, B Kral, L Yanek, PF O'Reilly, MI McCarthy, C Jaquish, DJ Couper, A Chakravarti, BM Psaty, LC Becker, MA Province, E Boerwinkle, T Quertermous, L Palotie, MR Jarvelin, DM Becker, SL Kardia, JI Rotter, YD Chen, IB Borecki
Striatum Gene Expression Correlates for SHAKE measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The SHAKE measures Morphine - wet dog shakes under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
A list of genes whose transcript abundance in the PFC changed significantly 4 hours after an acute dose of ethanol (1.8 g/kg). This list was generated using Fisher's Combined Probability test to analyze saline vs ethanol S-scores across B6 and D2 inbred strains (n=3) and 27 BXD RI lines (n=1). Statistical significance was determined using 1,000 permutations of S-score data and selecting for probe-sets with q-values < 0.05. Aaron Wolen 5-26-10.
Authors:
Wolen AR, Phillips CA, Langston MA, Putman AH, Vorster PJ, Bruce NA, York TP, Williams RW, Miles MF
The production of 12 out of 27 measured factors was induced by CEsHUT including IL-1β, TNF and IL-1Ra. In contrast to sIL-1Ra production, that of IL-1β and TNF was inhibited by HDL, corroborating previous results. In addition, CEsHUT induced monocytes to produce factors involved in their localization, survival and differentiation such as CCL5 (RANTES), CCL2 (MCP-1), interferon-γ (IFNγ), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage-CSF (M-CSF). The production of the latter was moderate and it was not affected by HDL.
Authors:
Gruaz L, Delucinge-Vivier C, Descombes P, Dayer JM, Burger D
cocaine related behavior 14 (Cocrb14) spans 43.765096 - 93.765096 Mbp (NCBI Build 37) on Chr 15. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for METH responses for home cage activity on Chr15 at D15Mit7 (36.50 Mbp , Build 37)
Description:
METH responses for home cage activity spans 11.50 - 61.50 Mbp (NCBI Build 37) on Chr15. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol acceptance on Chr15 at D15Mit60 (57.48 Mbp , Build 37)
Description:
alcohol acceptance spans 32.48 - 82.48 Mbp (NCBI Build 37) on Chr15. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
McClearn GE, Tarantino LM, Rodriguez LA, Jones BC, Blizard DA, Plomin R
QTL for cocaine related behavior on Chr15 at D15Mit3 (83.88 Mbp , Build 37)
Description:
cocaine related behavior spans 58.88 - 108.88 Mbp (NCBI Build 37) on Chr15. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - Cocaine vs. Saline DNA microarray increased expression 20 mg / kg / day for 7 days Pair-wise comparisons were made between all 4 conditions (WT Saline, WT Cocaine, KO Saline, KO Cocaine), which generated 4 lists of genes 1.2-fold differentially expressed with a P < 0.05. Genes that were significantly regulated by these criteria in the first duplicate study and validated directly via qPCR were included in the final lists. (NIF Table ID 36 [42])
Authors:
Renthal W, Maze I, Krishnan V, Covington HE 3rd, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ
Acute and chronic alcohol exposure was analyzed in 534 (C57BL/6J x C3H/HeJ)F2 mice. Behavioral testing was done using 5 traits, acute drug effect, forced ethanol drinking, withdrawal studies ethanol preference and stress induced ethanol drinking. The following QTL were found in a genome wide scan: Following the QTL is the Chromosome , cM location, and LOD score, Eih1 (Chr 1, 85 cM, LOD 6.6), Eih2 (Chr 7, 10 cM, LOD 3.6), Ceih1 (Chr 3, 55 cM, LOD 4.1), Ceih2 (Chr 6, 24.7 cM, LOD 4.1), Ceih3 (Chr 13, 39 cM, LOD 4.1), Eia1(Chr 1, 65 cM, LOD 10.3 and 10.4), Eiwa1 (Chr 7, 50 cM, LOD 4.4), Eiwa2(Chr 11, 43.1 cM, LOD 4.1),Aldd1(Chr 5, 42 cM, LOD 13.2), Aldd2(Chr 12, 18 cM, LOD 5.3),Eiwax1(Chr 1, 79 cM, LOD 6.5), Eiwax2(Chr 5, 59 cM, LOD 15.0), Eiwax3(Chr 12, 21 cM, LOD 3.6), Methp1(Chr 16, 31.4 cM, LOD 4.3), Mec1(Chr 16, 19.4 cM, LOD 5.1), Epbs1(Chr 16, 33 cM, LOD 4.1), Ecbs1(Chr 16, 29.4 cM, LOD 4.8), Mec2(Chr 1, 109 cM, LOD 3.9), Mec3(Chr 2, 109 cM, LOD 4.3), Mec4(Chr 5, 29 cM, LOD 3.9), Mec5(Chr 10, 2 cM, LOD 5.0), Mec6(Chr 15, 49 cM, LOD 5.2, 95% CI 6.7–56.7).
Authors:
Drews E, Rcz I, Lacava AD, Barth A, Bilkei-Gorz A, Wienker TF, Zimmer A
Ethanol Preference from BXD lines span 58586243-108586243. This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Marker Loci associated with 10% Ethanol Preferences Drinking at p<0.05 (Two Tailed) in the BXD RI set and the Correlation Coefficient, p and Estimated LOD. D15Mit33 (83586243 NCBI 37) p=0.05, LOD=0.08 overall LOD BXD & Select Line 2.4.
QTL for Voluntary Ethanol Consumption on LS x SS RI lines spans 43765164-93765164 .This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Chr 15 D15Mit3 39 cM VEC (females) 0.02
In the present study Aaq1, a previously mapped QTL on mouse Chromosome 15 linked to alcohol acceptance, is confirmed using a (C57BL/6J x DBA/2J)F2 population. Aaq1 mapped to 15 cM (D15Mit60)- 48 cM (D15Mit34) on mouse Chromosome 15 with a peak LOD score of 3.8 at approximately 30 cM. C57BL/6J-derived alleles confer increased alcohol acceptance in a dominant fashion at Aaq1. A potential candidate gene for Aaq1 is the peripheral benzodiazepine receptor gene, Bzrp.
Authors:
McClearn GE, Tarantino LM, Rodriguez LA, Jones BC, Blizard DA, Plomin R
QTL mapping results for B6D2F2 mice in regions provisionally identified in BXD RI mice for free-choice ethanol consumption. Peak D15Mit33 58586243-108586243. This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org)
Analysis of 2 Lore5 interval specific congenic strains (ISCS) excluded Mapk8ip as a candidate gene for Lore5. The Lore5 interval appears to be localized between D15Mit94 (29 cM) and D15Mit93 (43.7).
Authors:
Ehringer MA, Thompson J, Conroy O, Yang F, Hink R, Bennett B, Johnson TE, Sikela JM
Genes associated with Homo sapiens that interact with the MeSH term 'Azacitidine' (D001374). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Arsenic' (D001151). Incorporates data from 87 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Coumestrol' (D003375). Incorporates data from 6 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
GeneWeaver