List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration. The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
W Chen, D Stambolian, AO Edwards, KE Branham, M Othman, J Jakobsdottir, N Tosakulwong, MA Pericak-Vance, PA Campochiaro, ML Klein, PL Tan, YP Conley, A Kanda, L Kopplin, Y Li, KJ Augustaitis, AJ Karoukis, WK Scott, A Agarwal, JL Kovach, SG Schwartz, EA Postel, M Brooks, KH Baratz, WL Brown, AJ Brucker, A Orlin, G Brown, A Ho, C Regillo, L Donoso, L Tian, B Kaderli, D Hadley, SA Hagstrom, NS Peachey, R Klein, BE Klein, N Gotoh, K Yamashiro, F Ferris Iii, JA Fagerness, R Reynolds, LA Farrer, IK Kim, JW Miller, M Cortón, A Carracedo, M Sanchez-Salorio, EW Pugh, KF Doheny, M Brion, MM Deangelis, DE Weeks, DJ Zack, EY Chew, JR Heckenlively, N Yoshimura, SK Iyengar, PJ Francis, N Katsanis, JM Seddon, JL Haines, MB Gorin, GR Abecasis, A Swaroop
A member of the family of tissue inhibitor of metalloproteinases. Mutations of the gene for TIMP3 PROTEIN causes Sorsby fundus dystrophy.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration. The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Yu, TR Bhangale, J Fagerness, S Ripke, G Thorleifsson, PL Tan, EH Souied, AJ Richardson, JE Merriam, GH Buitendijk, R Reynolds, S Raychaudhuri, KA Chin, L Sobrin, E Evangelou, PH Lee, AY Lee, N Leveziel, DJ Zack, B Campochiaro, P Campochiaro, RT Smith, GR Barile, RH Guymer, R Hogg, U Chakravarthy, LD Robman, O Gustafsson, H Sigurdsson, W Ortmann, TW Behrens, K Stefansson, AG Uitterlinden, CM van Duijn, JR Vingerling, CC Klaver, R Allikmets, MA Brantley, PN Baird, N Katsanis, U Thorsteinsdottir, JP Ioannidis, MJ Daly, RR Graham, JM Seddon
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Advanced age-related macular degeneration. The EFO term atrophic macular degeneration, age-related macular degeneration, wet macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
LG Fritsche, W Igl, JN Bailey, F Grassmann, S Sengupta, JL Bragg-Gresham, KP Burdon, SJ Hebbring, C Wen, M Gorski, IK Kim, D Cho, D Zack, E Souied, HP Scholl, E Bala, KE Lee, DJ Hunter, RJ Sardell, P Mitchell, JE Merriam, V Cipriani, JD Hoffman, T Schick, YT Lechanteur, RH Guymer, MP Johnson, Y Jiang, CM Stanton, GH Buitendijk, X Zhan, AM Kwong, A Boleda, M Brooks, L Gieser, R Ratnapriya, KE Branham, JR Foerster, JR Heckenlively, MI Othman, BJ Vote, HH Liang, E Souzeau, IL McAllister, T Isaacs, J Hall, S Lake, DA Mackey, IJ Constable, JE Craig, TE Kitchner, Z Yang, Z Su, H Luo, D Chen, H Ouyang, K Flagg, D Lin, G Mao, H Ferreyra, K Stark, CN von Strachwitz, A Wolf, C Brandl, G Rudolph, M Olden, MA Morrison, DJ Morgan, M Schu, J Ahn, G Silvestri, EE Tsironi, KH Park, LA Farrer, A Orlin, A Brucker, M Li, CA Curcio, S Mohand-Saïd, JA Sahel, I Audo, M Benchaboune, AJ Cree, CA Rennie, SV Goverdhan, M Grunin, S Hagbi-Levi, P Campochiaro, N Katsanis, FG Holz, F Blond, H Blanché, JF Deleuze, RP Igo, B Truitt, NS Peachey, SM Meuer, CE Myers, EL Moore, R Klein, MA Hauser, EA Postel, MD Courtenay, SG Schwartz, JL Kovach, WK Scott, G Liew, AG Tan, B Gopinath, JC Merriam, RT Smith, JC Khan, H Shahid, AT Moore, JA McGrath, R Laux, MA Brantley, A Agarwal, L Ersoy, A Caramoy, T Langmann, NT Saksens, EK de Jong, CB Hoyng, MS Cain, AJ Richardson, TM Martin, J Blangero, DE Weeks, B Dhillon, CM van Duijn, KF Doheny, J Romm, CC Klaver, C Hayward, MB Gorin, ML Klein, PN Baird, AI den Hollander, S Fauser, JR Yates, R Allikmets, JJ Wang, DA Schaumberg, BE Klein, SA Hagstrom, I Chowers, AJ Lotery, T Léveillard, K Zhang, MH Brilliant, AW Hewitt, A Swaroop, EY Chew, MA Pericak-Vance, M DeAngelis, D Stambolian, JL Haines, SK Iyengar, BH Weber, GR Abecasis, IM Heid
This set lists genes that are up-regulated after medium-term treatment of human peripheral blood monocytes with interleukin-4 or interleukin-13. Up-regulation was assayed by a variety of methods including microarray analysis, RT-PCR, and immunofluorescence. All genes identified in the study were converted to HGNC identifiers by manual inspection.
Gene expression changes in the post-mortem nucleus accumbens of chronic heroin abusers. Overall, little overlap in gene expression profiles was seen between the two drug-abusing cohorts: out of the approximately 39,000 transcripts investigated, the abundance of only 25 was significantly changed in both cocaine and heroin abusers, with nearly one-half of these being altered in opposite directions. 1050 Transcripts had different in abundance between the majority of heroin subjects and their matched controls.
Study analyzed 812 differentially expressed gene candidates from peripheral blood mononuclear cells (PBMC) from morphine and saline treated rats, and suggests similarities between the gene expression profile in PBMCs and in the brain of morphine-treated rats. This set contains the 79 genes implicated by this study to modulate expression during chronic morphine treatment.
Authors:
Desjardins S, Belkai E, Crete D, Cordonnier L, Scherrmann JM, Noble F, Marie-Claire C
Striatum Gene Expression Correlates for AMDIST90 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMDIST90 measures Morphine distance (cm) travelled minutes 75-90 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for CONSTRICT measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The CONSTRICT measures Morphine Response Severity of abdominal constriction under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for MORPH_ADIST_2 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The MORPH_ADIST_2 measures Morphine Open Field TOTAL distance (cm) travelled under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for MORPH_VCOUNT_2 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The MORPH_VCOUNT_2 measures Morphine TOTAL vertical activity counts under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for SPD_TIMEDOWEL0SEC measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The SPD_TIMEDOWEL0SEC measures Dowel Test - Time 0 Sec under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for VERCNT45 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The VERCNT45 measures Morphine Vertical Activity 30-45 min under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
These genes are a 1 class SAM significant (1% FDR) in nucleus accumbens (core + shell) for saline treated ("basal") control vs. Fyn KO mice. The list was filtered for an average Sscore >2.0 or <-2.0. Data from Farris and Miles, PLoS One, 2013.
Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test; from Flatscher-Bader et al., 2005
Authors:
Flatscher-Bader T, van der Brug M, Hwang JW, Gochee PA, Matsumoto I, Niwa S, Wilce PA
DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats. Fold change is average ratio of AA to ANA. From Worst et al., 2005
Authors:
Worst TJ, Tan JC, Robertson DJ, Freeman WM, Hyytia P, Kiianmaa K, Vrana KE
QTL for alcohol preference on Chr10 at NA (71.07 Mbp , Build 37)
Description:
alcohol preference spans 46.07 - 96.07 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol withdrawal on Chr10 at Ha1 (98.44 Mbp , Build 37)
Description:
ethanol withdrawal spans 73.44 - 123.44 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for home cage activity on Chr10 at D10Mit144 (102.84 Mbp , Build 37)
Description:
METH responses for home cage activity spans 77.84 - 127.84 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
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