A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
Generated by gene2mesh v. 1.1.1
RNA-Seq was performed to discover gene expression
changes in the hippocampus of rats in withdrawal from
chronic alcohol exposure. RNA-Seq was performed on the
hippocampus from control, ethanol (no withdrawal), and
ethanol plus withdrawal (24 h) groups. The largest number
of differentially expressed (DE) genes were in the
control vs. withdrawal comparison (925 out of 18,118
detected; q < 0.1)
Authors:
Wei-Yang Chen, Hu Chen, Kana Hamada, Eleonora Gatta, Ying Chen, Huaibo Zhang, Jenny Drnevich, Harish R Krishnan, Mark Maienschein-Cline, Dennis R Grayson, Subhash C Pandey, Amy W Lasek
Total cellular RNA from Th0 and Th17 cells were subjected to microarray analysis. Fold induction was represented by the ratio of normalized gene expression in Th17 cells versus the expression in Th0 cells.
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Multiple sclerosis. The EFO term multiple sclerosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
E Jakkula, V Leppä, AM Sulonen, T Varilo, S Kallio, A Kemppinen, S Purcell, K Koivisto, P Tienari, ML Sumelahti, I Elovaara, T Pirttilä, M Reunanen, A Aromaa, AB Oturai, HB Søndergaard, HF Harbo, IL Mero, SB Gabriel, DB Mirel, SL Hauser, L Kappos, C Polman, PL De Jager, DA Hafler, MJ Daly, A Palotie, J Saarela, L Peltonen
"Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
"Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
"Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
"Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
"Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
"Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
HALLMARK_IL6_JAK_STAT3_SIGNALING
Genes up-regulated by IL6 <a href='http://www.ncbi.nlm.nih.gov/gene/3569'>[GeneID=3569]</a> via STAT3 <a href='http://www.ncbi.nlm.nih.gov/gene/6774'>[GeneID=6774]</a>, e.g., during acute phase response.
h - Hallmark genesets containing coherently expressed signatures derived by aggregating many MSigDB gene sets to represent well-defined biological states or processes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Crohn's disease. The EFO term Crohn's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JC Barrett, S Hansoul, DL Nicolae, JH Cho, RH Duerr, JD Rioux, SR Brant, MS Silverberg, KD Taylor, MM Barmada, A Bitton, T Dassopoulos, LW Datta, T Green, AM Griffiths, EO Kistner, MT Murtha, MD Regueiro, JI Rotter, LP Schumm, AH Steinhart, SR Targan, RJ Xavier, C Libioulle, C Sandor, M Lathrop, J Belaiche, O Dewit, I Gut, S Heath, D Laukens, M Mni, P Rutgeerts, A Van Gossum, D Zelenika, D Franchimont, JP Hugot, M de Vos, S Vermeire, E Louis, LR Cardon, CA Anderson, H Drummond, E Nimmo, T Ahmad, NJ Prescott, CM Onnie, SA Fisher, J Marchini, J Ghori, S Bumpstead, R Gwilliam, M Tremelling, P Deloukas, J Mansfield, D Jewell, J Satsangi, CG Mathew, M Parkes, M Georges, MJ Daly
Hippocampus Gene Expression Correlates for VONFREYTHRESHOLDMEAN measured in BXD RI Females & Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The VONFREYTHRESHOLDMEAN measures Mechanical Sensitivity-Von Frey Threshold under the domain Pain. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for ACTITOT_ETHA measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ACTITOT_ETHA measures Total distance traveled (cm) following ethanol under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
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