from Lewohl et al., 2000; from case group one (identical to case group used in PCR-differential display experiments reported by Fan et al., 1999); includes three uncomplicated alcoholics, one alcoholic with cirrhosis, and one alcoholic with concomitant Wernicke encephalopathy
Authors:
Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA
QTL spans- 118.3-168.3 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Ethanol consumption in mice was analyzed in selectively breed mice derived from an F2 population of intercrossed (C57BL/6J x DBA/2J)F1 mice. Whereas C57BL/6J are high consumers of alcohol and DBA/2J are low consumers. The concentration of ethanol used was 10%. With low preference mice and high preference mice mated for a maximum of 4 generations. In generation 4 of the Low selected line a significant QTL was observed and associated with D3Mit17. Authors suggest Adh1 may be a candidate gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Coumestrol' (D003375). Incorporates data from 6 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'nickel sulfate' (C029938). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term '2,3-bis(3'-hydroxybenzyl)butyrolactone' (C029497). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Aflatoxin B1' (D016604). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Ethanol Induced Hypothermia Chr# 3 rs3710548 (145932289) with right flanking marker rs3719390 (85222358) and left marker rs30801216 (156802752). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with activity response to ethanol 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147806689)
Authors:
Malmanger B, Lawler M, Coulombe S, Murray R, Cooper S, Polyakov Y, Belknap J, Hitzemann R
QTL associated with "alcohol preference locus 3, male specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147694263)
QTL associated with atherosclerotic lesion area 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147806703)
QTL associated with atherosclerotic lesion area 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (115533310)
QTL associated with bone response to mechanical loading 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (143227451)
QTL associated with cytokine deficiency colitis susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (126744151)
QTL associated with cystic fibrosis survival to weaning 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (100779519)
QTL associated with P. chabaudi malaria resistance QTL 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (127399252)
Authors:
Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, Foote S, Gros P
QTL associated with circulating hormone level QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (142848413)
Authors:
Harper JM, Galecki AT, Burke DT, Pinkosky SL, Miller RA
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