List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Spherical equivalent (joint main effects and education interaction). The EFO term self reported educational attainment, refractive error measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Q Fan, VJ Verhoeven, R Wojciechowski, VA Barathi, PG Hysi, JA Guggenheim, R Höhn, V Vitart, AP Khawaja, K Yamashiro, SM Hosseini, T Lehtimäki, Y Lu, T Haller, J Xie, C Delcourt, M Pirastu, J Wedenoja, P Gharahkhani, C Venturini, M Miyake, AW Hewitt, X Guo, J Mazur, JE Huffman, KM Williams, O Polasek, H Campbell, I Rudan, Z Vatavuk, JF Wilson, PK Joshi, G McMahon, B St Pourcain, DM Evans, CL Simpson, TH Schwantes-An, RP Igo, A Mirshahi, A Cougnard-Gregoire, C Bellenguez, M Blettner, O Raitakari, M Kähönen, I Seppala, T Zeller, T Meitinger, JS Ried, C Gieger, L Portas, EM van Leeuwen, N Amin, AG Uitterlinden, F Rivadeneira, A Hofman, JR Vingerling, YX Wang, X Wang, E Tai-Hui Boh, MK Ikram, C Sabanayagam, P Gupta, V Tan, L Zhou, CE Ho, W Lim, RW Beuerman, R Siantar, ES Tai, E Vithana, E Mihailov, CC Khor, C Hayward, RN Luben, PJ Foster, BE Klein, R Klein, HS Wong, P Mitchell, A Metspalu, T Aung, TL Young, M He, O Pärssinen, CM van Duijn, J Jin Wang, C Williams, JB Jonas, YY Teo, DA Mackey, K Oexle, N Yoshimura, AD Paterson, N Pfeiffer, TY Wong, PN Baird, D Stambolian, JE Wilson, CY Cheng, CJ Hammond, CC Klaver, SM Saw, JS Rahi, JF Korobelnik, JP Kemp, NJ Timpson, GD Smith, JE Craig, KP Burdon, RD Fogarty, SK Iyengar, E Chew, S Janmahasatian, NG Martin, S MacGregor, L Xu, M Schache, V Nangia, S Panda-Jonas, AF Wright, JR Fondran, JH Lass, S Feng, JH Zhao, KT Khaw, NJ Wareham, T Rantanen, J Kaprio, CP Pang, LJ Chen, PO Tam, V Jhanji, AL Young, A Döring, LJ Raffel, MF Cotch, X Li, SP Yip, MK Yap, G Biino, S Vaccargiu, M Fossarello, B Fleck, S Yazar, JW Tideman, M Tedja, MM Deangelis, M Morrison, L Farrer, X Zhou, W Chen, N Mizuki, A Meguro, KM Mäkelä
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
Gene set has 67 genes associated with nicotine abstinence. Backgound: In this study, genome-wide association studies are conducted for two human cohorts, one group demonstrating nicotine dependence, and another that successfully quit smoking. The study shows that some genetic components associated with ability to quit overlap while many do not. To perform the study, DNA samples were obtained from NIH volunteers and allelic frequencies of the samples were analyzed using Affymetrix array analysis. Table S2.
Authors:
Drgon T, Montoya I, Johnson C, Liu QR, Walther D, Hamer D, Uhl GR
Cerebellum Gene Expression Correlates for ACTI05_ETHA measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The ACTI05_ETHA measures Distance traveled (cm) during the first five minutes after ethanol under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for NEVCOUNT15 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The NEVCOUNT15 measures Novel environment vertical activity counts min 0-15 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for OF_REAR_15_20 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The OF_REAR_15_20 measures Open Field - Total rears 15-20 minutes under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Differentially expressed in the Nucleus accumbens following 24 hr continuous 9.5g/kg/day alcohol drinking vs. water drinking in alcohol preferring rats. Estimated BAC in the alcohol exposed group was > 85mg%. The 406 significanlty different probe sets represent 374 uniquely named genes, with most gene expression differences in the range of 1.1-1.3 fold.
QTL for high-dose ethanol actions on Chr18 at D18Mit7 (73.95 Mbp , Build 37)
Description:
high-dose ethanol actions spans 48.95 - 98.95 Mbp (NCBI Build 37) on Chr18. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
Genes associated with Homo sapiens that interact with the MeSH term 'Urea' (D014508). Incorporates data from 15 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Amiodarone' (D000638). Incorporates data from 38 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Hydroxyurea' (D006918). Incorporates data from 4 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Zinc' (D015032). Incorporates data from 59 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Aflatoxin B1' (D016604). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Plant Extracts' (D010936). Incorporates data from 489 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'arsenic trioxide' (C006632). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Atrazine' (D001280). Incorporates data from 48 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Vanadium' (D014639). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with nan that interact with the MeSH term 'Phloretin' (D010693). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Silicon Dioxide' (D012822). Incorporates data from 9 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Average rotarod training latency Chr# 18 rs4137441(88803388) with right flanking marker rs13483426(70283358) and left marker rs4137441(88803388). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with insulin dependent diabetes susceptibility 21.1. The confidence interval is Chr18:74588921-84295862 bp,+strand
Authors:
Hollis-Moffatt JE, Hook SM, Merriman TR
Add Selected GeneSets to Project(s)
Warning: You are not signed in. Adding these genesets to a project will create a guest account for you.
Guest accounts are temporary, and will be removed within 24 hours of creation. Guest accounts can be registered as full accounts, but you cannot associate a guest account with an existing account.
If you already have an account, you should sign into that account before proceeding.