List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sex hormone-binding globulin levels. The EFO term sex hormone globulin binding measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
AD Coviello, R Haring, M Wellons, D Vaidya, T Lehtimäki, S Keildson, KL Lunetta, C He, M Fornage, V Lagou, M Mangino, NC Onland-Moret, B Chen, J Eriksson, M Garcia, YM Liu, A Koster, K Lohman, LP Lyytikäinen, AK Petersen, J Prescott, L Stolk, L Vandenput, AR Wood, WV Zhuang, A Ruokonen, AL Hartikainen, A Pouta, S Bandinelli, R Biffar, G Brabant, DG Cox, Y Chen, S Cummings, L Ferrucci, MJ Gunter, SE Hankinson, H Martikainen, A Hofman, G Homuth, T Illig, JO Jansson, AD Johnson, D Karasik, M Karlsson, J Kettunen, DP Kiel, P Kraft, J Liu, Ö Ljunggren, M Lorentzon, M Maggio, MR Markus, D Mellström, I Miljkovic, D Mirel, S Nelson, L Morin Papunen, PH Peeters, I Prokopenko, L Raffel, M Reincke, AP Reiner, K Rexrode, F Rivadeneira, SM Schwartz, D Siscovick, N Soranzo, D Stöckl, S Tworoger, AG Uitterlinden, CH van Gils, RS Vasan, HE Wichmann, G Zhai, S Bhasin, M Bidlingmaier, SJ Chanock, I De Vivo, TB Harris, DJ Hunter, M Kähönen, S Liu, P Ouyang, TD Spector, YT van der Schouw, J Viikari, H Wallaschofski, MI McCarthy, TM Frayling, A Murray, S Franks, MR Järvelin, FH de Jong, O Raitakari, A Teumer, C Ohlsson, JM Murabito, JR Perry
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sex hormone-binding globulin levels. The EFO term sex hormone globulin binding measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Prescott, DJ Thompson, P Kraft, SJ Chanock, T Audley, J Brown, J Leyland, E Folkerd, D Doody, SE Hankinson, DJ Hunter, KB Jacobs, M Dowsett, DG Cox, DF Easton, I De Vivo
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Protein quantitative trait loci. The EFO term sex hormone globulin binding measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
D Melzer, JR Perry, D Hernandez, AM Corsi, K Stevens, I Rafferty, F Lauretani, A Murray, JR Gibbs, G Paolisso, S Rafiq, J Simon-Sanchez, H Lango, S Scholz, MN Weedon, S Arepalli, N Rice, N Washecka, A Hurst, A Britton, W Henley, J van de Leemput, R Li, AB Newman, G Tranah, T Harris, V Panicker, C Dayan, A Bennett, MI McCarthy, A Ruokonen, MR Jarvelin, J Guralnik, S Bandinelli, TM Frayling, A Singleton, L Ferrucci
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hormone measurements. The EFO term sex hormone globulin binding measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Z Chen, S Tao, Y Gao, J Zhang, Y Hu, L Mo, ST Kim, X Yang, A Tan, H Zhang, X Qin, L Li, Y Wu, S Zhang, SL Zheng, J Xu, Z Mo, J Sun
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Testosterone levels. The EFO term testosterone measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
C Ohlsson, H Wallaschofski, KL Lunetta, L Stolk, JR Perry, A Koster, AK Petersen, J Eriksson, T Lehtimäki, IT Huhtaniemi, GL Hammond, M Maggio, AD Coviello, L Ferrucci, M Heier, A Hofman, KL Holliday, JO Jansson, M Kähönen, D Karasik, MK Karlsson, DP Kiel, Y Liu, O Ljunggren, M Lorentzon, LP Lyytikäinen, T Meitinger, D Mellström, D Melzer, I Miljkovic, M Nauck, M Nilsson, B Penninx, SR Pye, RS Vasan, M Reincke, F Rivadeneira, A Tajar, A Teumer, AG Uitterlinden, J Ulloor, J Viikari, U Völker, H Völzke, HE Wichmann, TS Wu, WV Zhuang, E Ziv, FC Wu, O Raitakari, A Eriksson, M Bidlingmaier, TB Harris, A Murray, FH de Jong, JM Murabito, S Bhasin, L Vandenput, R Haring
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Androgen levels. The EFO term dihydrotestosterone measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
G Jin, J Sun, ST Kim, J Feng, Z Wang, S Tao, Z Chen, L Purcell, S Smith, WB Isaacs, RS Rittmaster, SL Zheng, LD Condreay, J Xu
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Androgen levels. The EFO term testosterone measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
G Jin, J Sun, ST Kim, J Feng, Z Wang, S Tao, Z Chen, L Purcell, S Smith, WB Isaacs, RS Rittmaster, SL Zheng, LD Condreay, J Xu
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hormone measurements. The EFO term testosterone measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Z Chen, S Tao, Y Gao, J Zhang, Y Hu, L Mo, ST Kim, X Yang, A Tan, H Zhang, X Qin, L Li, Y Wu, S Zhang, SL Zheng, J Xu, Z Mo, J Sun
GWAS: hormone measurement, sex hormone globulin binding measurement
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sex hormone levels. The EFO term hormone measurement, sex hormone globulin binding measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
KS Ruth, PJ Campbell, S Chew, EM Lim, N Hadlow, BG Stuckey, SJ Brown, B Feenstra, J Joseph, GL Surdulescu, HF Zheng, JB Richards, A Murray, TD Spector, SG Wilson, JR Perry
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Estradiol levels. The EFO term estradiol measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Prescott, DJ Thompson, P Kraft, SJ Chanock, T Audley, J Brown, J Leyland, E Folkerd, D Doody, SE Hankinson, DJ Hunter, KB Jacobs, M Dowsett, DG Cox, DF Easton, I De Vivo
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Testosterone levels. The EFO term testosterone measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Prescott, DJ Thompson, P Kraft, SJ Chanock, T Audley, J Brown, J Leyland, E Folkerd, D Doody, SE Hankinson, DJ Hunter, KB Jacobs, M Dowsett, DG Cox, DF Easton, I De Vivo
Positional candidate genes for HOTPLATE_MEANOF2 in BXD RI Females on Chr11
Description:
Position candidates for HOTPLATE_MEANOF2 measured in BXD RI Females. HOTPLATE_MEANOF2 measures Thermal Nociception Hot Plate Avg of 2Trials under the domain Pain. The QTL found was a Significant QTL and spans 68 Mb to 70 Mb.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for COCA_TEST_DRUG measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The COCA_TEST_DRUG measures Cocaine CPP- Time (s) in drug-paired compartment a under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for PTOSIS measured in BXD RI Females & Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The PTOSIS measures Morphine - Severity of ptosis under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VOCA_THRESHOLD measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VOCA_THRESHOLD measures Vocalization Threshold - shock intensity (mA) under the domain Stress Vocalization. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
F2 mice from a hybrid cross of C57BL/6J and FVB/NJ had heightened consumption of EtOH in 2 bottle, water versus ethanol, choice, with accending ethanol levels. Chromosome 11 had multiple suggestive markers, with LOD scores reflecting both additive and dominance variation taken together, as shown in Fig. 5.
Authors:
Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK
Heterozygote mice from a hybrid cross of C57BL/6J and FVB/NJ had heightened EtOH consumption, preference or blood EtOH concentration compared to either homozygous groups. The magnitude of dominant deviation on Chr. 11, as noted in Fig. 9, was measured after a drinking in the dark paradigm, 24hr two-bottle-choice and subsequent blood ethanol concentration measurement.
Authors:
Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK
QTL for chronic alcohol withdrawal severity on Chr11 at D11Mit4 (58.98 Mbp , Build 37)
Description:
chronic alcohol withdrawal severity spans 33.98 - 83.98 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for alcohol preference locus on Chr11 at NA (70.38 Mbp , Build 37)
Description:
alcohol preference locus spans 45.38 - 95.38 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol preference locus on Chr11 at D11Mit35 (80.34 Mbp , Build 37)
Description:
alcohol preference locus spans 55.34 - 105.34 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for nicotine sensitivity on Chr11 at D11Mit39 (81.17 Mbp , Build 37)
Description:
nicotine sensitivity spans 56.17 - 106.17 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes associated with Homo sapiens that interact with the MeSH term '(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid' (C086910). Incorporates data from 12 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'delta-hexachlorocyclohexane' (C086916). Incorporates data from 9 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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