"Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs" by Soundararajan et al. 2014
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Refractive error. The EFO term Abnormality of refraction was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
VJ Verhoeven, PG Hysi, R Wojciechowski, Q Fan, JA Guggenheim, R Höhn, S MacGregor, AW Hewitt, A Nag, CY Cheng, E Yonova-Doing, X Zhou, MK Ikram, GH Buitendijk, G McMahon, JP Kemp, BS Pourcain, CL Simpson, KM Mäkelä, T Lehtimäki, M Kähönen, AD Paterson, SM Hosseini, HS Wong, L Xu, JB Jonas, O Pärssinen, J Wedenoja, SP Yip, DW Ho, CP Pang, LJ Chen, KP Burdon, JE Craig, BE Klein, R Klein, T Haller, A Metspalu, CC Khor, ES Tai, T Aung, E Vithana, WT Tay, VA Barathi, P Chen, R Li, J Liao, Y Zheng, RT Ong, A Döring, DM Evans, NJ Timpson, AJ Verkerk, T Meitinger, O Raitakari, F Hawthorne, TD Spector, LC Karssen, M Pirastu, F Murgia, W Ang, A Mishra, GW Montgomery, CE Pennell, PM Cumberland, I Cotlarciuc, P Mitchell, JJ Wang, M Schache, S Janmahasatian, S Janmahasathian, RP Igo, JH Lass, E Chew, SK Iyengar, TG Gorgels, I Rudan, C Hayward, AF Wright, O Polasek, Z Vatavuk, JF Wilson, B Fleck, T Zeller, A Mirshahi, C Müller, AG Uitterlinden, F Rivadeneira, JR Vingerling, A Hofman, BA Oostra, N Amin, AA Bergen, YY Teo, JS Rahi, V Vitart, C Williams, PN Baird, TY Wong, K Oexle, N Pfeiffer, DA Mackey, TL Young, CM van Duijn, SM Saw, JE Bailey-Wilson, D Stambolian, CC Klaver, CJ Hammond
Striatum Gene Expression Correlates for AMCNT15 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMCNT15 measures Morphine photocell counts minutes 0-15 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
cocaine related behavior 1 (Cocrb1) spans 79.870166 - 121.405905 Mbp (NCBI Build 37) on Chr 1. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for METH responses for body temperature on Chr1 at D1Ncvs75 (79.87 Mbp , Build 37)
Description:
METH responses for body temperature spans 54.87 - 104.87 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for chronic alcohol withdrawal severity on Chr1 at D1Mit46 (83.89 Mbp , Build 37)
Description:
chronic alcohol withdrawal severity spans 58.89 - 108.89 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for METH responses for home cage activity on Chr1 at D1Ncvs41 (101.77 Mbp , Build 37)
Description:
METH responses for home cage activity spans 76.77 - 126.77 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes associated with Homo sapiens that interact with the MeSH term '5-dihydrocortisone' (C045993). Incorporates data from 1538 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Aldehydes' (D000447). Incorporates data from 10 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'pentanal' (C046012). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'propionaldehyde' (C005556). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'butyraldehyde' (C018475). Incorporates data from 7 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
"any structural anomaly of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any functional anomaly and/or activity of the spheroid organ and optic nerve that serves to detect light" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"the observable morphological and physiological characteristics of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that are manifested through development and lifespan" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly in the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of the spheroid organ and optic nerve that serves to detect light" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"the observable morphological, physiological, behavioral and other characteristics of mammalian organisms that are manifested through development and lifespan" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of the cells of the nervous system that receive, conduct, and transmit impulses" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
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