Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. To identify genes that might be related to beta4-containing nAChRs activity, we compared the mRNA expression profiles of brains from beta4-/- and wild-type mice using Affymetrix U74Av2 microarray. Seventy-seven genes are significantly differentiated.
Differentially expressed in the Nucleus accumbens following 24 hr continuous 9.5g/kg/day alcohol drinking vs. water drinking in alcohol preferring rats. Estimated BAC in the alcohol exposed group was > 85mg%. The 406 significanlty different probe sets represent 374 uniquely named genes, with most gene expression differences in the range of 1.1-1.3 fold.
Genes associated with Homo sapiens that interact with the MeSH term 'manganese chloride' (C025340). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Aflatoxin B1' (D016604). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Gadus morhua that interact with the MeSH term 'methylmercuric chloride' (C004925). Incorporates data from 4 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Manganese' (D008345). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
QTL associated with circulating hormone level QTL 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (53317604)
QTL associated with experimental severe malaria resistance. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56130259)
Authors:
Nagayasu E, Nagakura K, Akaki M, Tamiya G, Makino S, Nakano Y, Kimura M, Aikawa M
QTL associated with leishmaniasis resistance 13. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45135967)
Authors:
Havelkov H, Badalov J, Svobodov M, Vojtkov J, Kurey I, Vladimirov V, Demant P, Lipoldov M
QTL associated with lung squamous cell carcinoma 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (55539802)
Authors:
Wang Y, Zhang Z, Yan Y, Lemon WJ, LaRegina M, Morrison C, Lubet R, You M
QTL associated with lung tumor shape-determining 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (39646515)
QTL associated with "macronutrient intake, fat 2". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (53220218)
Authors:
Smith Richards BK, Belton BN, Poole AC, Mancuso JJ, Churchill GA, Li R, Volaufova J, Zuberi A, York B
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