QTL associated with heart weight quantitative locus 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (73709112)
Authors:
Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B
Genes associated with Homo sapiens that interact with the MeSH term '(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)' (C517041). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate cancer. The EFO term prostate carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
R Takata, S Akamatsu, M Kubo, A Takahashi, N Hosono, T Kawaguchi, T Tsunoda, J Inazawa, N Kamatani, O Ogawa, T Fujioka, Y Nakamura, H Nakagawa
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate cancer. The EFO term prostate carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
RA Eeles, Z Kote-Jarai, AA Al Olama, GG Giles, M Guy, G Severi, K Muir, JL Hopper, BE Henderson, CA Haiman, J Schleutker, FC Hamdy, DE Neal, JL Donovan, JL Stanford, EA Ostrander, SA Ingles, EM John, SN Thibodeau, D Schaid, JY Park, A Spurdle, J Clements, JL Dickinson, C Maier, W Vogel, T Dörk, TR Rebbeck, KA Cooney, L Cannon-Albright, PO Chappuis, P Hutter, M Zeegers, R Kaneva, HW Zhang, YJ Lu, WD Foulkes, DR English, DA Leongamornlert, M Tymrakiewicz, J Morrison, AT Ardern-Jones, AL Hall, LT O'Brien, RA Wilkinson, EJ Saunders, EC Page, EJ Sawyer, SM Edwards, DP Dearnaley, A Horwich, RA Huddart, VS Khoo, CC Parker, N Van As, CJ Woodhouse, A Thompson, T Christmas, C Ogden, CS Cooper, MC Southey, A Lophatananon, JF Liu, LN Kolonel, L Le Marchand, T Wahlfors, TL Tammela, A Auvinen, SJ Lewis, A Cox, LM FitzGerald, JS Koopmeiners, DM Karyadi, EM Kwon, MC Stern, R Corral, AD Joshi, A Shahabi, SK McDonnell, TA Sellers, J Pow-Sang, S Chambers, J Aitken, RA Gardiner, J Batra, MA Kedda, F Lose, A Polanowski, B Patterson, J Serth, A Meyer, M Luedeke, K Stefflova, AM Ray, EM Lange, J Farnham, H Khan, C Slavov, A Mitkova, G Cao, DF Easton
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists also possess anti-addictive characteristics. PPAR agonists decrease ethanol consumption and reduce withdrawal severity and susceptibility to stress-induced relapse in rodents. However, the cellular and molecular mechanisms facilitating these properties have yet to be investigated. We tested three PPAR agonists in a continuous access two-bottle choice (2BC) drinking paradigm and found that tesaglitazar (PPARα/γ; 1.5 mg/kg) and fenofibrate (PPARα; 150 mg/kg) decreased ethanol consumption in male C57BL/6J mice while bezafibrate (PPARα/γ/β; 75 mg/kg) did not. We hypothesized that changes in brain gene expression following fenofibrate and tesaglitazar treatment lead to reduced ethanol drinking. We studied unbiased genomic profiles in areas of the brain known to be important for ethanol dependence, the prefrontal cortex (PFC) and amygdala, and also profiled gene expression in liver. Genomic profiles from the non-effective bezafibrate treatment were used to filter out genes not associated with ethanol consumption. Because PPAR agonists are anti-inflammatory, they would be expected to target microglia and astrocytes. Surprisingly, PPAR agonists produced a strong neuronal signature in mouse brain, and fenofibrate and tesaglitazar (but not bezafibrate) targeted a subset of GABAergic interneurons in the amygdala. Weighted gene co-expression network analysis (WGCNA) revealed co-expression of treatment-significant genes. Functional annotation of these gene networks suggested that PPAR agonists might act via neuropeptide and dopaminergic signaling pathways in the amygdala. Our results reveal gene targets through which PPAR agonists can affect alcohol consumption behavior.
Authors:
Laura B Ferguson, Dana Most, Yuri A Blednov, R Adron Harris
Differential Expression of Emotional and Physical Stress(Fold Change >1) in Ventral Tegmental Area using eight week-old male C57BL/6J. Statistics reported as fold change.
Authors:
Warren BL, Vialou VF, Alcantara LF, Wright KN, Feng J, Kennedy PJ, Laplant Q, Shen L, Nestler EJ
A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 2; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.
Generated by gene2mesh v. 1.1.1
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "cellular response to interleukin-1", which is defined as "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "response to interleukin-1", which is defined as "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Genes associated with Homo sapiens that interact with the MeSH term '2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one' (C093973). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes with particular expression in the Orbital area, lateral part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Orbital area, ventrolateral part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior olfactory nucleus, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
The production of 12 out of 27 measured factors was induced by CEsHUT including IL-1β, TNF and IL-1Ra. In contrast to sIL-1Ra production, that of IL-1β and TNF was inhibited by HDL, corroborating previous results. In addition, CEsHUT induced monocytes to produce factors involved in their localization, survival and differentiation such as CCL5 (RANTES), CCL2 (MCP-1), interferon-γ (IFNγ), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage-CSF (M-CSF). The production of the latter was moderate and it was not affected by HDL.
Authors:
Gruaz L, Delucinge-Vivier C, Descombes P, Dayer JM, Burger D
QTL associated with total body bone mineral density 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (94235479)
Authors:
Masinde GL, Li X, Gu W, Wergedal J, Mohan S, Baylink DJ
Genes with particular expression in the Infralimbic area, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Dorsal peduncular area, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
QTL Associated with Renal pathology. On Chromosome 1 with a LOD score= 2.2, p-value =. From a(n) intercross of QTL Associated with Renal pathology. On Chromosome 15 with a LOD score= 2.5, p-value =. From a(n) intercross of
Authors:
Herrera VL, Tsikoudakis A, Ponce LR, Matsubara Y, Ruiz-Opazo N
QTL Associated with Bone mineral density. On Chromosome 15 with a LOD score= 12.8, p-value =1.00E-04. From a(n) intercross of
Authors:
Koller DL, Liu L, Alam I, Sun Q, Econs MJ, Foroud T, Turner CH
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