Genes associated with Homo sapiens that interact with the MeSH term '1-Methyl-3-isobutylxanthine' (D015056). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Infantile hypertrophic pyloric stenosis. The EFO term infantile hypertrophic pyloric stenosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
B Feenstra, F Geller, C Krogh, MV Hollegaard, S Gørtz, HA Boyd, JC Murray, DM Hougaard, M Melbye
QTL associated with lymph node cytotoxic T lymphocyte percentage 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (122652363)
QTL associated with Neuroadapted Sindbis viral RNA level 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (128607202)
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Thyroid cancer. The EFO term thyroid carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Gudmundsson, P Sulem, DF Gudbjartsson, JG Jonasson, A Sigurdsson, JT Bergthorsson, H He, T Blondal, F Geller, M Jakobsdottir, DN Magnusdottir, S Matthiasdottir, SN Stacey, OB Skarphedinsson, H Helgadottir, W Li, R Nagy, E Aguillo, E Faure, E Prats, B Saez, M Martinez, GI Eyjolfsson, US Bjornsdottir, H Holm, K Kristjansson, ML Frigge, H Kristvinsson, JR Gulcher, T Jonsson, T Rafnar, H Hjartarsson, JI Mayordomo, A de la Chapelle, J Hrafnkelsson, U Thorsteinsdottir, A Kong, K Stefansson
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists also possess anti-addictive characteristics. PPAR agonists decrease ethanol consumption and reduce withdrawal severity and susceptibility to stress-induced relapse in rodents. However, the cellular and molecular mechanisms facilitating these properties have yet to be investigated. We tested three PPAR agonists in a continuous access two-bottle choice (2BC) drinking paradigm and found that tesaglitazar (PPARα/γ; 1.5 mg/kg) and fenofibrate (PPARα; 150 mg/kg) decreased ethanol consumption in male C57BL/6J mice while bezafibrate (PPARα/γ/β; 75 mg/kg) did not. We hypothesized that changes in brain gene expression following fenofibrate and tesaglitazar treatment lead to reduced ethanol drinking. We studied unbiased genomic profiles in areas of the brain known to be important for ethanol dependence, the prefrontal cortex (PFC) and amygdala, and also profiled gene expression in liver. Genomic profiles from the non-effective bezafibrate treatment were used to filter out genes not associated with ethanol consumption. Because PPAR agonists are anti-inflammatory, they would be expected to target microglia and astrocytes. Surprisingly, PPAR agonists produced a strong neuronal signature in mouse brain, and fenofibrate and tesaglitazar (but not bezafibrate) targeted a subset of GABAergic interneurons in the amygdala. Weighted gene co-expression network analysis (WGCNA) revealed co-expression of treatment-significant genes. Functional annotation of these gene networks suggested that PPAR agonists might act via neuropeptide and dopaminergic signaling pathways in the amygdala. Our results reveal gene targets through which PPAR agonists can affect alcohol consumption behavior.
Authors:
Laura B Ferguson, Dana Most, Yuri A Blednov, R Adron Harris
A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.
Generated by gene2mesh v. 1.1.1
QTL associated with hereditary spherocytosis modifer 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (80557940)
Authors:
Peters LL, Swearingen RA, Andersen SG, Gwynn B, Lambert AJ, Li R, Lux SE, Churchill GA
QTL associated with hepatocarcinogenesis in females 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34380179)
QTL Associated with Kidney mass. On Chromosome 1 with a LOD score= 5.7, p-value =. From a(n) intercross of
Authors:
Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE
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