Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.
Authors:
Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J, Lee SH, Lambert A, Zhao ZZ, Roseman F, Guo Q, Gordon SD, Wallace L, Henders AK, Visscher PM, Kraft P, Martin NG, Morris AP, Treloar SA, Kennedy SH, Missmer SA, Montgomery GW, Zondervan KT
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Waist-hip ratio. The EFO term waist-hip ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
KL Monda, GK Chen, KC Taylor, C Palmer, TL Edwards, LA Lange, MC Ng, AA Adeyemo, MA Allison, LF Bielak, G Chen, M Graff, MR Irvin, SK Rhie, G Li, Y Liu, Y Liu, Y Lu, MA Nalls, YV Sun, MK Wojczynski, LR Yanek, MC Aldrich, A Ademola, CI Amos, EV Bandera, CH Bock, A Britton, U Broeckel, Q Cai, NE Caporaso, CS Carlson, J Carpten, G Casey, WM Chen, F Chen, YD Chen, CW Chiang, GA Coetzee, E Demerath, SL Deming-Halverson, RW Driver, P Dubbert, MF Feitosa, Y Feng, BI Freedman, EM Gillanders, O Gottesman, X Guo, T Haritunians, T Harris, CC Harris, AJ Hennis, DG Hernandez, LH McNeill, TD Howard, BV Howard, VJ Howard, KC Johnson, SJ Kang, BJ Keating, S Kolb, LH Kuller, A Kutlar, CD Langefeld, G Lettre, K Lohman, V Lotay, H Lyon, JE Manson, W Maixner, YA Meng, KR Monroe, I Morhason-Bello, AB Murphy, JC Mychaleckyj, R Nadukuru, KL Nathanson, U Nayak, A N'diaye, B Nemesure, SY Wu, MC Leske, C Neslund-Dudas, M Neuhouser, S Nyante, H Ochs-Balcom, A Ogunniyi, TO Ogundiran, O Ojengbede, OI Olopade, JR Palmer, EA Ruiz-Narvaez, ND Palmer, MF Press, E Rampersaud, LJ Rasmussen-Torvik, JL Rodriguez-Gil, B Salako, EE Schadt, AG Schwartz, DA Shriner, D Siscovick, SB Smith, S Wassertheil-Smoller, EK Speliotes, MR Spitz, L Sucheston, H Taylor, BO Tayo, MA Tucker, DJ Van Den Berg, DR Edwards, Z Wang, JK Wiencke, TW Winkler, JS Witte, M Wrensch, X Wu, JJ Yang, AM Levin, TR Young, NA Zakai, M Cushman, KA Zanetti, JH Zhao, W Zhao, Y Zheng, J Zhou, RG Ziegler, JM Zmuda, JK Fernandes, GS Gilkeson, DL Kamen, KJ Hunt, IJ Spruill, CB Ambrosone, S Ambs, DK Arnett, L Atwood, DM Becker, SI Berndt, L Bernstein, WJ Blot, IB Borecki, EP Bottinger, DW Bowden, G Burke, SJ Chanock, RS Cooper, J Ding, D Duggan, MK Evans, C Fox, WT Garvey, JP Bradfield, H Hakonarson, SF Grant, A Hsing, L Chu, JJ Hu, D Huo, SA Ingles, EM John, JM Jordan, EK Kabagambe, SL Kardia, RA Kittles, PJ Goodman, EA Klein, LN Kolonel, L Le Marchand, S Liu, B McKnight, RC Millikan, TH Mosley, B Padhukasahasram, LK Williams, SR Patel, U Peters, CA Pettaway, PA Peyser, BM Psaty, S Redline, CN Rotimi, BA Rybicki, MM Sale, PJ Schreiner, LB Signorello, AB Singleton, JL Stanford, SS Strom, MJ Thun, M Vitolins, W Zheng, JH Moore, SM Williams, S Ketkar, X Zhu, AB Zonderman, C Kooperberg, GJ Papanicolaou, BE Henderson, AP Reiner, JN Hirschhorn, RJ Loos, KE North, CA Haiman
This gene set contains 12 downregulated genes that were differentially expressed in five brain regions (amygdale, frontal cortex, striatum, nucleus acumbens, and hippocampus) in congenic mice strains in which inbred alcohol preferring (iP) chromosome 4 QTL interval was transferred to inbred non-alcohol preferring (iNP) mice strain (NP.P) mice. This study identified genes in the chromosome 4 QTL interval that affect alcoholic predisposition in these strain (NP.P) mice.
Hippocampus Gene Expression Correlates for VONFREYTHRESHOLDMEAN measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The VONFREYTHRESHOLDMEAN measures Mechanical Sensitivity-Von Frey Threshold under the domain Pain. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for LD_LIGHT_DIST measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The LD_LIGHT_DIST measures Light-Dark Box Total distance traveled in light compartment under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for LD_LIGHT_DIST measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The LD_LIGHT_DIST measures Light-Dark Box Total distance traveled in light compartment under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for NEINCOUNT30 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The NEINCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the center under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for NEINDIST30 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The NEINDIST30 measures Novel environment locomotion (cm) 15-30 min in the center under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for OF_DIST_0_5 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The OF_DIST_0_5 measures Open Field - Total distance traveled 0-5 minutes under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for OF_HAB_RATIO measured in BXD RI Females & Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The OF_HAB_RATIO measures Open Field - Habituation ratio (First:Last intervals) under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SALINE_ACOUNT_2 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SALINE_ACOUNT_2 measures Open Field TOTAL locomotion (activity beam breaks) under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SALINE_ADIST_2 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SALINE_ADIST_2 measures Open Field TOTAL locomotion ( cm in 1 hr) under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SHCOUNT30 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SHCOUNT30 measures Open Field - locomotion (activity beam breaks) 15-30 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SHCOUNT45 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SHCOUNT45 measures Open Field - locomotion (activity beam breaks) 30-45 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SHCOUNT60 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SHCOUNT60 measures Open Field - locomotion (activity beam breaks) 45-60 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SHDIST30 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SHDIST30 measures Open Field - Total horizontal distance (cm) 15-30 min post saline (10 ml/kg) under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SHDIST45 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SHDIST45 measures Open Field - Total horizontal distance (cm) 30-45 min post saline (10 ml/kg) under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_PCT_PPI_70 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_PCT_PPI_70 measures Prepulse inhibition at 70db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_PCT_STARTLE_70 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_PCT_STARTLE_70 measures Acoustic Startle Response Percentage of maximum startle response at 70 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for COCA_BASE_DRUG measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The COCA_BASE_DRUG measures CPP - Time (s) in drug-paired compartment a under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
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