List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Obesity (early onset extreme). The EFO term obesity was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
E Wheeler, N Huang, EG Bochukova, JM Keogh, S Lindsay, S Garg, E Henning, H Blackburn, RJ Loos, NJ Wareham, S O'Rahilly, ME Hurles, I Barroso, IS Farooqi
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
CJ Willer, EK Speliotes, RJ Loos, S Li, CM Lindgren, IM Heid, SI Berndt, AL Elliott, AU Jackson, C Lamina, G Lettre, N Lim, HN Lyon, SA McCarroll, K Papadakis, L Qi, JC Randall, RM Roccasecca, S Sanna, P Scheet, MN Weedon, E Wheeler, JH Zhao, LC Jacobs, I Prokopenko, N Soranzo, T Tanaka, NJ Timpson, P Almgren, A Bennett, RN Bergman, SA Bingham, LL Bonnycastle, M Brown, NP Burtt, P Chines, L Coin, FS Collins, JM Connell, C Cooper, GD Smith, EM Dennison, P Deodhar, P Elliott, MR Erdos, K Estrada, DM Evans, L Gianniny, C Gieger, CJ Gillson, C Guiducci, R Hackett, D Hadley, AS Hall, AS Havulinna, J Hebebrand, A Hofman, B Isomaa, KB Jacobs, T Johnson, P Jousilahti, Z Jovanovic, KT Khaw, P Kraft, M Kuokkanen, J Kuusisto, J Laitinen, EG Lakatta, J Luan, RN Luben, M Mangino, WL McArdle, T Meitinger, A Mulas, PB Munroe, N Narisu, AR Ness, K Northstone, S O'Rahilly, C Purmann, MG Rees, M Ridderstråle, SM Ring, F Rivadeneira, A Ruokonen, MS Sandhu, J Saramies, LJ Scott, A Scuteri, K Silander, MA Sims, K Song, J Stephens, S Stevens, HM Stringham, YC Tung, TT Valle, CM Van Duijn, KS Vimaleswaran, P Vollenweider, G Waeber, C Wallace, RM Watanabe, DM Waterworth, N Watkins, JC Witteman, E Zeggini, G Zhai, MC Zillikens, D Altshuler, MJ Caulfield, SJ Chanock, IS Farooqi, L Ferrucci, JM Guralnik, AT Hattersley, FB Hu, MR Jarvelin, M Laakso, V Mooser, KK Ong, WH Ouwehand, V Salomaa, NJ Samani, TD Spector, T Tuomi, J Tuomilehto, M Uda, AG Uitterlinden, NJ Wareham, P Deloukas, TM Frayling, LC Groop, RB Hayes, DJ Hunter, KL Mohlke, L Peltonen, D Schlessinger, DP Strachan, HE Wichmann, MI McCarthy, M Boehnke, I Barroso, GR Abecasis, JN Hirschhorn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systemic lupus erythematosus. The EFO term systemic lupus erythematosus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
G Hom, RR Graham, B Modrek, KE Taylor, W Ortmann, S Garnier, AT Lee, SA Chung, RC Ferreira, PV Pant, DG Ballinger, R Kosoy, FY Demirci, MI Kamboh, AH Kao, C Tian, I Gunnarsson, AA Bengtsson, S Rantapää-Dahlqvist, M Petri, S Manzi, MF Seldin, L Rönnblom, AC Syvänen, LA Criswell, PK Gregersen, TW Behrens
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
LSI derived gene associations with keyword query Reelin. The list contains the top 300 genes associated with Reelin from the >13000 mouse homolog gene collection
cocaine related behavior 4 (Cocrb4) spans 120.266777 - 170.266777 Mbp (NCBI Build 37) on Chr 3. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for cocaine related behavior on Chr3 at D3Ncvs49 (145.27 Mbp , Build 37)
Description:
cocaine related behavior spans 120.27 - 170.27 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL spans- 118.3-168.3 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Ethanol consumption in mice was analyzed in selectively breed mice derived from an F2 population of intercrossed (C57BL/6J x DBA/2J)F1 mice. Whereas C57BL/6J are high consumers of alcohol and DBA/2J are low consumers. The concentration of ethanol used was 10%. With low preference mice and high preference mice mated for a maximum of 4 generations. In generation 4 of the Low selected line a significant QTL was observed and associated with D3Mit17. Authors suggest Adh1 may be a candidate gene.
QTL for METH responses for body temperature on Chr3 at P40-rs4 (154.89 Mbp , Build 37)
Description:
METH responses for body temperature spans 129.89 - 179.89 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes associated with Homo sapiens that interact with the MeSH term 'entinostat' (C118739). Incorporates data from 11 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Arsenic' (D001151). Incorporates data from 87 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Smoke' (D012906). Incorporates data from 54 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term '(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine' (C516138). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Thimerosal' (D013849). Incorporates data from 20 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'vorinostat' (C111237). Incorporates data from 13 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'nickel sulfate' (C029938). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Arbutin' (D001104). Incorporates data from 68 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Tretinoin' (D014212). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'cobaltous chloride' (C018021). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Oryzias latipes that interact with the MeSH term 'Estradiol' (D004958). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Ovis aries that interact with the MeSH term 'Progesterone' (D011374). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'panobinostat' (C496932). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Aflatoxin B1' (D016604). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'potassium chromate(VI)' (C027373). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Authors:
None
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