List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Number of children ever born. The EFO term reproductive behaviour measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
N Barban, R Jansen, R de Vlaming, A Vaez, JJ Mandemakers, FC Tropf, X Shen, JF Wilson, DI Chasman, IM Nolte, V Tragante, SW van der Laan, JR Perry, A Kong, TS Ahluwalia, E Albrecht, L Yerges-Armstrong, G Atzmon, K Auro, K Ayers, A Bakshi, D Ben-Avraham, K Berger, A Bergman, L Bertram, LF Bielak, G Bjornsdottir, MJ Bonder, L Broer, M Bui, C Barbieri, A Cavadino, JE Chavarro, C Turman, MP Concas, HJ Cordell, G Davies, P Eibich, N Eriksson, T Esko, J Eriksson, F Falahi, JF Felix, MA Fontana, L Franke, I Gandin, AJ Gaskins, C Gieger, EP Gunderson, X Guo, C Hayward, C He, E Hofer, H Huang, PK Joshi, S Kanoni, R Karlsson, S Kiechl, A Kifley, A Kluttig, P Kraft, V Lagou, C Lecoeur, J Lahti, R Li-Gao, PA Lind, T Liu, E Makalic, C Mamasoula, L Matteson, H Mbarek, PF McArdle, G McMahon, SF Meddens, E Mihailov, M Miller, SA Missmer, C Monnereau, PJ van der Most, R Myhre, MA Nalls, T Nutile, IP Kalafati, E Porcu, I Prokopenko, KB Rajan, J Rich-Edwards, CA Rietveld, A Robino, LM Rose, R Rueedi, KA Ryan, Y Saba, D Schmidt, JA Smith, L Stolk, E Streeten, A Tönjes, G Thorleifsson, S Ulivi, J Wedenoja, J Wellmann, P Willeit, J Yao, L Yengo, JH Zhao, W Zhao, DV Zhernakova, N Amin, H Andrews, B Balkau, N Barzilai, S Bergmann, G Biino, H Bisgaard, K Bønnelykke, DI Boomsma, JE Buring, H Campbell, S Cappellani, M Ciullo, SR Cox, F Cucca, D Toniolo, G Davey-Smith, IJ Deary, G Dedoussis, P Deloukas, CM van Duijn, EJ de Geus, JG Eriksson, DA Evans, JD Faul, CF Sala, P Froguel, P Gasparini, G Girotto, HJ Grabe, KH Greiser, PJ Groenen, HG de Haan, J Haerting, TB Harris, AC Heath, K Heikkilä, A Hofman, G Homuth, EG Holliday, J Hopper, E Hyppönen, B Jacobsson, VW Jaddoe, M Johannesson, A Jugessur, M Kähönen, E Kajantie, SL Kardia, B Keavney, I Kolcic, P Koponen, P Kovacs, F Kronenberg, Z Kutalik, M La Bianca, G Lachance, WG Iacono, S Lai, T Lehtimäki, DC Liewald, CM Lindgren, Y Liu, R Luben, M Lucht, R Luoto, P Magnus, PK Magnusson, NG Martin, M McGue, R McQuillan, SE Medland, C Meisinger, D Mellström, A Metspalu, M Traglia, L Milani, P Mitchell, GW Montgomery, D Mook-Kanamori, R de Mutsert, EA Nohr, C Ohlsson, J Olsen, KK Ong, L Paternoster, A Pattie, BW Penninx, M Perola, PA Peyser, M Pirastu, O Polasek, C Power, J Kaprio, LJ Raffel, K Räikkönen, O Raitakari, PM Ridker, SM Ring, K Roll, I Rudan, D Ruggiero, D Rujescu, V Salomaa, D Schlessinger, H Schmidt, R Schmidt, N Schupf, J Smit, R Sorice, TD Spector, JM Starr, D Stöckl, K Strauch, M Stumvoll, MA Swertz, U Thorsteinsdottir, AR Thurik, NJ Timpson, JY Tung, AG Uitterlinden, S Vaccargiu, J Viikari, V Vitart, H Völzke, P Vollenweider, D Vuckovic, J Waage, GG Wagner, JJ Wang, NJ Wareham, DR Weir, G Willemsen, J Willeit, AF Wright, KT Zondervan, K Stefansson, RF Krueger, JJ Lee, DJ Benjamin, D Cesarini, PD Koellinger, M den Hoed, H Snieder, MC Mills
"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "molecular_function", which is defined as "The actions of a single gene product or complex at the molecular level consisting of a single biochemical activity or multiple causally linked biochemical activities. A given gene product may exhibit one or more molecular functions." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "biological regulation", which is defined as "Any process that modulates a measurable attribute of any biological process, quality or function." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "biological_process", which is defined as "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "protein binding", which is defined as "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "cellular_component", which is defined as "The part of a cell, extracellular environment or virus in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "regulation of biological process", which is defined as "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "binding", which is defined as "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Neocortex Gene Expression Correlates for C1VCOUNT15 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The C1VCOUNT15 measures Open Field rears 0-15 min post cocaine under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for C1VCOUNT45 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The C1VCOUNT45 measures Open Field rears 30-45 min post cocaine under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for LOC_CHCL_VCOUNT_3 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The LOC_CHCL_VCOUNT_3 measures Cocaine Open Field TOTAL rears under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Whole Brain Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Cerebellum Gene Expression Correlates for ROTASALINE_DIFF measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The ROTASALINE_DIFF measures Difference in time on rotarod between saline and ethanol under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for TNOVEL_VCOUNT_1 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The TNOVEL_VCOUNT_1 measures Novel Open Field - TOTAL rears in the center + periphery under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for LM_CONTEXT_ACTIVITY measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The LM_CONTEXT_ACTIVITY measures Contextual activity in fear conditioning apparatus under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for NOVEL_VCOUNT_1 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NOVEL_VCOUNT_1 measures Open Field Inovel TOTAL rears in the center under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
QTL for ethanol conditioned taste aversion on Chr2 at NA (35.13 Mbp , Build 37)
Description:
ethanol conditioned taste aversion spans 10.13 - 60.13 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for climbing on Chr2 at Brp13 (41.42 Mbp , Build 37)
Description:
METH responses for climbing spans 16.42 - 66.42 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol consumption on Chr2 at D2Mit7 (47.24 Mbp , Build 37)
Description:
ethanol consumption spans 22.24 - 72.24 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol preference on Chr2 at D2Mit61 (59.53 Mbp , Build 37)
Description:
alcohol preference spans 34.53 - 84.53 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
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