QTL Associated with Joint/bone inflammation. On Chromosome 4 with a LOD score= 2.3, p-value =. From a(n) F2 of LEWxF344
Authors:
Wilder RL, Griffiths MM, Remmers EF, Cannon GW, Caspi RR, Kawahito Y, Gulko PS, Longman RE, Dracheva SV, Du Y, Sun SH, Wang J, Shepard JS, Joe B, Ge L, Chen S, Chang L, Hoffman J, Silver PB, Reese VR
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
Average rotarod training latency Chr# 6 rs6239023 (94005991) with right flanking marker rs3672029(75345665) and left marker rs30316697(130188177). This was mapped in 300 + (b6x129)F2 mice.
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Chronic kidney disease. The EFO term chronic kidney disease, serum creatinine measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Köttgen, C Pattaro, CA Böger, C Fuchsberger, M Olden, NL Glazer, A Parsa, X Gao, Q Yang, AV Smith, JR O'Connell, M Li, H Schmidt, T Tanaka, A Isaacs, S Ketkar, SJ Hwang, AD Johnson, A Dehghan, A Teumer, G Paré, EJ Atkinson, T Zeller, K Lohman, MC Cornelis, NM Probst-Hensch, F Kronenberg, A Tönjes, C Hayward, T Aspelund, G Eiriksdottir, LJ Launer, TB Harris, E Rampersaud, BD Mitchell, DE Arking, E Boerwinkle, M Struchalin, M Cavalieri, A Singleton, F Giallauria, J Metter, IH de Boer, T Haritunians, T Lumley, D Siscovick, BM Psaty, MC Zillikens, BA Oostra, M Feitosa, M Province, M de Andrade, ST Turner, A Schillert, A Ziegler, PS Wild, RB Schnabel, S Wilde, TF Munzel, TS Leak, T Illig, N Klopp, C Meisinger, HE Wichmann, W Koenig, L Zgaga, T Zemunik, I Kolcic, C Minelli, FB Hu, A Johansson, W Igl, G Zaboli, SH Wild, AF Wright, H Campbell, D Ellinghaus, S Schreiber, YS Aulchenko, JF Felix, F Rivadeneira, AG Uitterlinden, A Hofman, M Imboden, D Nitsch, A Brandstätter, B Kollerits, L Kedenko, R Mägi, M Stumvoll, P Kovacs, M Boban, S Campbell, K Endlich, H Völzke, HK Kroemer, M Nauck, U Völker, O Polasek, V Vitart, S Badola, AN Parker, PM Ridker, SL Kardia, S Blankenberg, Y Liu, GC Curhan, A Franke, T Rochat, B Paulweber, I Prokopenko, W Wang, V Gudnason, AR Shuldiner, J Coresh, R Schmidt, L Ferrucci, MG Shlipak, CM van Duijn, I Borecki, BK Krämer, I Rudan, U Gyllensten, JF Wilson, JC Witteman, PP Pramstaller, R Rettig, N Hastie, DI Chasman, WH Kao, IM Heid, CS Fox
Rats in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks. Additive QTL. Variance 11 , LOD 9.2 Peak Marker: D4Rat34 spans D4Mgh9(54828166) - D4Mit9(152570244). Strains were P, NP. Also known as Eoh1.
Authors:
Carr LG, Habegger K, Spence JP, Liu L, Lumeng L, Foroud T
QTL Associated with Consumption level. On Chromosome 1 with a LOD score= 2.7, p-value =0.258. From a(n) of QTL Associated with Consumption level. On Chromosome 12 with a LOD score= 2.7, p-value =0.439. From a(n) of QTL Associated with Consumption level. On Chromosome 1 with a LOD score= 3, p-value =0.28. From a(n) of QTL Associated with Consumption level. On Chromosome 1 with a LOD score= 2.3, p-value =0.74. From a(n) of QTL Associated with Consumption level. On Chromosome 6 with a LOD score= 2.2, p-value =0.791. From a(n) of QTL Associated with Consumption level. On Chromosome 2 with a LOD score= 2.4, p-value =0.667. From a(n) of QTL Associated with Consumption level. On Chromosome 4 with a LOD score= 8.6, p-value =1.00E-04. From a(n) intercross of
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