List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Mathematical ability in children with dyslexia. The EFO term mathematical ability was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
KU Ludwig, P Sämann, M Alexander, J Becker, J Bruder, K Moll, D Spieler, M Czisch, A Warnke, SJ Docherty, OS Davis, R Plomin, MM Nöthen, K Landerl, B Müller-Myhsok, P Hoffmann, J Schumacher, G Schulte-Körne, D Czamara
By analyzing Genome-Wide Association data of successful vs. unsuccessful nicotine-abstinent participants in independent clinical trials from 3 centers, study replicates quit-success genes. To conduct the study, three cohorts were used. Sample 1 consisting of subjects who received a double-blinded placebo-controlled trial of bupropion hydrochloride and a trial of NRT. Sample 2 consisted of subjects who were used in the trial of the clinical effectiveness of NRT. Sample 3 consisted of subjects who were used in the trial of the clinical effectiveness of bupropion hydrochloride.
Authors:
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C
Gene set comprises 32 smoking cessation genes. Background: Using results from genome wide association studies of nicotine dependent individuals who were successful in abstaining from cigarette smoking, study nominates genes important in nicotine dependence and in smoking cessation. Results were obtained using SNP allele frequency assessments of DNA prepared from nicotine-dependent European-American smoking cessation trial participants and control individuals.
Authors:
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE
Neocortex Gene Expression Correlates for ZM_EOPEN measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ZM_EOPEN measures Zero Maze - total entries in open quadrants under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for HAND_7HOURS measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The HAND_7HOURS measures Handling induced convulsions 7 hrs after ethanol under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for ZM_PCT_OPEN measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ZM_PCT_OPEN measures Zero Maze - Percentage open time under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
cocaine related behavior 6 (Cocrb6) spans 68.726231 - 118.726231 Mbp (NCBI Build 37) on Chr 5. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for cocaine related behavior on Chr5 at D5Mit7 (103.64 Mbp , Build 37)
Description:
cocaine related behavior spans 78.64 - 128.64 Mbp (NCBI Build 37) on Chr5. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for differences in cocaine responsiveness on Chr5 at Cyp3 (108.78 Mbp , Build 37)
Description:
differences in cocaine responsiveness spans 83.78 - 133.78 Mbp (NCBI Build 37) on Chr5. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for chewing on Chr5 at D5Mit10 (111.96 Mbp , Build 37)
Description:
METH responses for chewing spans 86.96 - 136.96 Mbp (NCBI Build 37) on Chr5. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for climbing on Chr5 at D5Byu4 (129.78 Mbp , Build 37)
Description:
METH responses for climbing spans 104.78 - 154.78 Mbp (NCBI Build 37) on Chr5. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Average rotarod training latency Chr# 5 rs13478110 (9741228) with right flanking marker rs13478092(3595407) and left marker rs3718776 (150393227). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with activity-distance traveled 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (113601539)
QTL associated with autoimmune extremity vasculitis in MRL mice 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (119175776)
Authors:
Yamada A, Miyazaki T, Lu LM, Ono M, Ito MR, Terada M, Mori S, Hata K, Nozaki Y, Nakatsuru S, Nakamura Y, Onji M, Nose M
QTL associated with B.burgdorferi-associated arthritis 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (120256981)
Authors:
Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ
QTL associated with B.burgdorferi-associated arthritis 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (96820800)
Authors:
Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ
QTL associated with behavioral response to methamphetamines 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (104668024)
QTL associated with body weight females and males day 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (126842654)
QTL associated with body weight day 30 males 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (104668024)
QTL associated with cytokine deficiency colitis susceptibility 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (93561953)
Authors:
de Buhr MF, Mhler M, Geffers R, Hansen W, Westendorf AM, Lauber J, Buer J, Schlegelberger B, Hedrich HJ, Bleich A
QTL associated with cystic fibrosis survival to weaning 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (107842159)
QTL associated with cholesterol absorption 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (112514368)
Authors:
Schwarz M, Davis DL, Vick BR, Russell DW
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