QTL for morphine preference on Chr6 at NA (1.89 Mbp , Build 37)
Description:
morphine preference spans 0.00 - 26.89 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for home cage activity on Chr6 at Met (13.99 Mbp , Build 37)
Description:
METH responses for home cage activity spans 0.00 - 38.99 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL associated with SGC/Knj cross B6 QTL 2. The confidence interval is Chr6:19862686-71272769 bp,+strand
Authors:
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
QTL associated with bladder tumor susceptibility 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (29701222)
Authors:
Higashi S, Murai T, Mori S, Kamoto T, Yoshitomi M, Arakawa Y, Makino S, Fukushima S, Yoshida O, Hiai H
QTL associated with cocaine induced activation 8. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (29701222)
QTL associated with circadian period of locomotor activity 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (51112078)
Authors:
Hofstetter JR, Trofatter JA, Kernek KL, Nurnberger JI, Mayeda AR
QTL associated with p-glycoprotein positive CD4 T cell subset 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34684663)
QTL associated with radiation-induced acute myeloid leukemia sensitivity 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (55149860)
Authors:
Boulton E, Cole C, Knight A, Cleary H, Snowden R, Plumb M
QTL associated with colon tumor susceptibility 13. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (59066367)
Authors:
Ruivenkamp CA, Csiks T, Klous AM, van Wezel T, Demant P
QTL associated with susceptibility to lung cancer 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (26247075)
Here, female High Drinking in the Dark (HDID) mice were stereotaxically injected with 0.5uL rAAV2/5-CMV-Cre-GFP and 0.5uL rAAV2-hSyn-DIO-hM3Dq-mCherry bilaterally into the NAc. A Drinking in the Dark (DID) experiment lasting 6 weeks was carried out with 2 fluid groups (water or ethanol) and 2 treatment groups (VEH/VEH/VEH or VEH/CNO/VEH). Mice were serially treated with vehicle prior to DID during week 1 to establish baseline drinking, CNO (1mg/kg) during weeks 2-5 to measure the effects of chronic treatment, and then mice were treated with vehicle again during week 6 to determine if there were any lasting effects of chronic CNO treatment. This gene set comprises 1,157 genes that were differentially expressed in water drinking HDID mice treated with CNO as compared to the water drinking and vehicle treated control group (H2O(CNO) vs H2O(VEH)).
Authors:
Darya Y. Pozhidayeva, Sean P. Farris, Calla M. Goeke, Evan J. Firsick, Kayla G. Townsley, Marina Guizzetti, and Angela R. Ozburn
Here, female High Drinking in the Dark (HDID) mice were stereotaxically injected with 0.5uL rAAV2/5-CMV-Cre-GFP and 0.5uL rAAV2-hSyn-DIO-hM3Dq-mCherry bilaterally into the NAc. A Drinking in the Dark (DID) experiment lasting 6 weeks was carried out with 2 fluid groups (water or ethanol) and 2 treatment groups (VEH/VEH/VEH or VEH/CNO/VEH). Mice were serially treated with vehicle prior to DID during week 1 to establish baseline drinking, CNO (1mg/kg) during weeks 2-5 to measure the effects of chronic treatment, and then mice were treated with vehicle again during week 6 to determine if there were any lasting effects of chronic CNO treatment. This gene set comprises 612 genes that were uniquely differentially expressed in the nucleus accumbens of only H2O drinking HDID mice treated with CNO as compared to the water drinking and vehicle treated control group.
Authors:
Darya Y. Pozhidayeva, Sean P. Farris, Calla M. Goeke, Evan J. Firsick, Kayla G. Townsley, Marina Guizzetti, and Angela R. Ozburn
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
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