QTL associated with Y-linked autoimmune acceleration QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56424004)
Authors:
Laporte C, Ballester B, Mary C, Izui S, Reininger L
QTL associated with spacial bias during navigation task 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (46945614)
QTL associated with spontaneous crescentic glomerulonephritis QTL 5. The confidence interval is Chr13:35968794-96872609 bp,+strand
Authors:
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
QTL associated with "cerebellum pattern fissures, declival 5". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56582797)
QTL associated with circadian period of locomotor activity 11. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (55673906)
Authors:
Hofstetter JR, Trofatter JA, Kernek KL, Nurnberger JI, Mayeda AR
QTL associated with Crh transcript abundance QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56786703)
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
QTL associated with Avp transcript abundance QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (85473357)
QTL associated with primordial germ cell tumor locus 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (70811542)
QTL associated with delta power in slow-wave sleep 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (85473357)
QTL associated with autoimmune extremity vasculitis in MRL mice 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (73811716)
Authors:
Yamada A, Miyazaki T, Lu LM, Ono M, Ito MR, Terada M, Mori S, Hata K, Nozaki Y, Nakatsuru S, Nakamura Y, Onji M, Nose M
QTL associated with cocaine induced activation 11. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (54579545)
QTL associated with experimental allergic encephalomyelitis susceptibility 13. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (67271283)
Authors:
Butterfield RJ, Blankenhorn EP, Roper RJ, Zachary JF, Doerge RW, Sudweeks J, Rose J, Teuscher C
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
QTL associated with insulin dependent diabetes susceptibility 14. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (41008627)
Authors:
Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI, Dick JE, Danska JS
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