GWAS: advanced glycation end-product measurement, type II diabetes mellitus
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Advanced glycation end-product levels. The EFO term advanced glycation end-product measurement, type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JN Adams, LM Raffield, SE Martelle, BI Freedman, CD Langefeld, JJ Carr, AJ Cox, DW Bowden
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Presence of antiphospholipid antibodies. The EFO term antiphospholipid antibody measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
N Müller-Calleja, H Rossmann, C Müller, P Wild, S Blankenberg, N Pfeiffer, H Binder, ME Beutel, D Manukyan, T Zeller, KJ Lackner
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hypertension. The EFO term hypertension was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Autism. The EFO term autism was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
R Anney, L Klei, D Pinto, R Regan, J Conroy, TR Magalhaes, C Correia, BS Abrahams, N Sykes, AT Pagnamenta, J Almeida, E Bacchelli, AJ Bailey, G Baird, A Battaglia, T Berney, N Bolshakova, S Bölte, PF Bolton, T Bourgeron, S Brennan, J Brian, AR Carson, G Casallo, J Casey, SH Chu, L Cochrane, C Corsello, EL Crawford, A Crossett, G Dawson, M de Jonge, R Delorme, I Drmic, E Duketis, F Duque, A Estes, P Farrar, BA Fernandez, SE Folstein, E Fombonne, CM Freitag, J Gilbert, C Gillberg, JT Glessner, J Goldberg, J Green, SJ Guter, H Hakonarson, EA Heron, M Hill, R Holt, JL Howe, G Hughes, V Hus, R Igliozzi, C Kim, SM Klauck, A Kolevzon, O Korvatska, V Kustanovich, CM Lajonchere, JA Lamb, M Laskawiec, M Leboyer, A Le Couteur, BL Leventhal, AC Lionel, XQ Liu, C Lord, L Lotspeich, SC Lund, E Maestrini, W Mahoney, C Mantoulan, CR Marshall, H McConachie, CJ McDougle, J McGrath, WM McMahon, NM Melhem, A Merikangas, O Migita, NJ Minshew, GK Mirza, J Munson, SF Nelson, C Noakes, A Noor, G Nygren, G Oliveira, K Papanikolaou, JR Parr, B Parrini, T Paton, A Pickles, J Piven, DJ Posey, A Poustka, F Poustka, A Prasad, J Ragoussis, K Renshaw, J Rickaby, W Roberts, K Roeder, B Roge, ML Rutter, LJ Bierut, JP Rice, J Salt, K Sansom, D Sato, R Segurado, L Senman, N Shah, VC Sheffield, L Soorya, I Sousa, V Stoppioni, C Strawbridge, R Tancredi, K Tansey, B Thiruvahindrapduram, AP Thompson, S Thomson, A Tryfon, J Tsiantis, H Van Engeland, JB Vincent, F Volkmar, S Wallace, K Wang, Z Wang, TH Wassink, K Wing, K Wittemeyer, S Wood, BL Yaspan, D Zurawiecki, L Zwaigenbaum, C Betancur, JD Buxbaum, RM Cantor, EH Cook, H Coon, ML Cuccaro, L Gallagher, DH Geschwind, M Gill, JL Haines, J Miller, AP Monaco, JI Nurnberger, AD Paterson, MA Pericak-Vance, GD Schellenberg, SW Scherer, JS Sutcliffe, P Szatmari, AM Vicente, VJ Vieland, EM Wijsman, B Devlin, S Ennis, J Hallmayer
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Brain connectivity. The EFO term brain connectivity measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
N Jahanshad, P Rajagopalan, X Hua, DP Hibar, TM Nir, AW Toga, CR Jack, AJ Saykin, RC Green, MW Weiner, SE Medland, GW Montgomery, NK Hansell, KL McMahon, GI de Zubicaray, NG Martin, MJ Wright, PM Thompson
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was White matter lesion progression (adjusted for white matter lesion burden at baseline). The EFO term white matter lesion progression measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
E Hofer, M Cavalieri, JC Bis, C DeCarli, M Fornage, S Sigurdsson, V Srikanth, S Trompet, BF Verhaaren, C Wolf, Q Yang, HH Adams, P Amouyel, A Beiser, BM Buckley, M Callisaya, G Chauhan, AJ de Craen, C Dufouil, CM van Duijn, I Ford, P Freudenberger, RF Gottesman, V Gudnason, G Heiss, A Hofman, T Lumley, O Martinez, B Mazoyer, C Moran, WJ Niessen, T Phan, BM Psaty, CL Satizabal, N Sattar, S Schilling, DK Shibata, PE Slagboom, A Smith, DJ Stott, KD Taylor, R Thomson, AM Töglhofer, C Tzourio, M van Buchem, J Wang, RG Westendorp, BG Windham, MW Vernooij, A Zijdenbos, R Beare, S Debette, MA Ikram, JW Jukema, LJ Launer, WT Longstreth, TH Mosley, S Seshadri, H Schmidt, R Schmidt
All genes from DisGeNet and OMIM with evidence for an association is Autism Spectrum Disorder, found using the query term "Autism Spectrum Disorders" are aggregated into this list. A binary score of 1 was added to indicate list membership.
Hippocampus Gene Expression Correlates for VONFREYTHRESHOLDMEAN measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The VONFREYTHRESHOLDMEAN measures Mechanical Sensitivity-Von Frey Threshold under the domain Pain. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for MDMA_ACT_MDA_1 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The MDMA_ACT_MDA_1 measures Locomotor response of 10 mg/kg MDMA injected on Day 2 under the domain MDMA. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for URINE measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The URINE measures Novel Open Field Number of urinations under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VERCNT15 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VERCNT15 measures Morphine vertical activity counts minutes 0-15 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VERCNT30 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VERCNT30 measures Morphine vertical activity counts minutes 15-30 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
After quality control, association analysis was performed on 310,605 SNPs with minor allele frequency >1% genotyped in 778 UK celiac cases and 1422 UK population controls
Authors:
van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C
cocaine related behavior 3 (Cocrb3) spans 114.482445 - 164.482445 Mbp (NCBI Build 37) on Chr 2. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for activity response to ethanol on Chr2 at NA (129.21 Mbp , Build 37)
Description:
activity response to ethanol spans 104.21 - 154.21 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for cocaine related behavior on Chr2 at D2Byu3 (139.48 Mbp , Build 37)
Description:
cocaine related behavior spans 114.48 - 164.48 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol induced locomotion on Chr2 at NA (141.12 Mbp , Build 37)
Description:
ethanol induced locomotion spans 116.12 - 166.12 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J Jr
QTL for high-dose ethanol actions on Chr2 at D2Mit21 (159.38 Mbp , Build 37)
Description:
high-dose ethanol actions spans 134.38 - 184.38 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
QTL for METH responses for climbing on Chr2 at D2Mc1 (162.34 Mbp , Build 37)
Description:
METH responses for climbing spans 137.34 - 187.34 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
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