Whole brain expression correlates of ethanol withdrawal in BXD RI mice based on phenotype data in the 1997 Buck et al manuscript. Expression correlates were generated using GeneNetwork.org
By analyzing Genome-Wide Association data of successful vs. unsuccessful nicotine-abstinent participants in independent clinical trials from 3 centers, study replicates quit-success genes. To conduct the study, three cohorts were used. Sample 1 consisting of subjects who received a double-blinded placebo-controlled trial of bupropion hydrochloride and a trial of NRT. Sample 2 consisted of subjects who were used in the trial of the clinical effectiveness of NRT. Sample 3 consisted of subjects who were used in the trial of the clinical effectiveness of bupropion hydrochloride.
Authors:
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C
QTL for ethanol withdrawal on Chr18 at Ms15-2 (4.62 Mbp , Build 37)
Description:
ethanol withdrawal spans 0.00 - 29.62 Mbp (NCBI Build 37) on Chr18. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - Cocaine vs. Saline DNA microarray increased expression 20 mg / kg / day for 7 days Pair-wise comparisons were made between all 4 conditions (WT Saline, WT Cocaine, KO Saline, KO Cocaine), which generated 4 lists of genes 1.2-fold differentially expressed with a P < 0.05. Genes that were significantly regulated by these criteria in the first duplicate study and validated directly via qPCR were included in the final lists. (NIF Table ID 36 [42])
Authors:
Renthal W, Maze I, Krishnan V, Covington HE 3rd, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ
Genes associated with Homo sapiens that interact with the MeSH term '2,3,5,6-tetrachlorophenate' (C039673). Incorporates data from 6 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
QTL associated with bone response to mechanical loading 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (6108402)
QTL associated with orthodenticle homolog 2 (Drosophila) modifier 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (21594126)
Authors:
Hide T, Hatakeyama J, Kimura-Yoshida C, Tian E, Takeda N, Ushio Y, Shiroishi T, Aizawa S, Matsuo I
QTL associated with radiation induced acute myeloid leukemia 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (12563850)
Authors:
Darakhshan F, Badie C, Moody J, Coster M, Finnon R, Finnon P, Edwards AA, Szluinska M, Skidmore CJ, Yoshida K, Ullrich R, Cox R, Bouffler SD
"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
"A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism." [GOC:jl]
"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
"The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah]
"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah]
"A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism." [GOC:jl]
Genes with particular expression in the Infralimbic area. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Agranular insular area, posterior part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Infralimbic area, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Gustatory areas, layer 4. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Agranular insular area, posterior part, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
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