Heterozygote mice from a hybrid cross of C57BL/6J and FVB/NJ had heightened EtOH consumption, preference or blood EtOH concentration compared to either homozygous groups. The magnitude of dominant deviation on Chr. 11, as noted in Fig. 9, was measured after a drinking in the dark paradigm, 24hr two-bottle-choice and subsequent blood ethanol concentration measurement.
Authors:
Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK
cocaine related behavior 12 (Cocrb12) spans 85.558736 - 135.558736 Mbp (NCBI Build 37) on Chr 11. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for alcohol preference locus on Chr11 at D11Mit35 (80.34 Mbp , Build 37)
Description:
alcohol preference locus spans 55.34 - 105.34 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for nicotine sensitivity on Chr11 at D11Mit39 (81.17 Mbp , Build 37)
Description:
nicotine sensitivity spans 56.17 - 106.17 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol preference locus on Chr11 at D11Mit35 (106.61 Mbp , Build 37)
Description:
alcohol preference locus spans 81.61 - 131.61 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - D1 receptor mutant vs. Wildtype DNA microarray Gene expression differences between mutant and wildtype D1 receptor mutant and wild-type mice were injected twice daily at 11:00 and 16:00 for 7 days with 20 mg / kg of cocaine. Gene expression differences 24 h after cocaine withdrawal. p<0.05 was considered as significant. Based on this criterion, we used a cutoff of at least a 1.2-fold difference in expression for further studies. (NIF Method ID 68)
Authors:
Zhang D, Zhang L, Tang Y, Zhang Q, Lou D, Sharp FR, Zhang J, Xu M
Genes associated with Homo sapiens that interact with the MeSH term 'Azacitidine' (D001374). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Tretinoin' (D014212). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Plant Extracts' (D010936). Incorporates data from 489 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'decabromobiphenyl ether' (C010902). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
QTL associated with "alcohol preference locus 18, male specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (112374453)
QTL associated with "alcohol preference locus 20, female specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (112374453)
QTL associated with Alzheimer's disease modifier 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (94407671)
Authors:
Sebastiani G, Krzywkowski P, Dudal S, Yu M, Paquette J, Malo D, Gervais F, Tremblay P
QTL associated with B.burgdorferi-associated arthritis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (83403911)
Authors:
Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ
QTL associated with berghei resistance locus 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (115323097)
Authors:
Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, Foote S, Gros P
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