The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
V$AFP1_Q6
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif ATTAAYTRCAC which matches annotation for ZHX2: zinc fingers and homeoboxes 2
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$OCT1_02
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNGAATATKCANNNN which matches annotation for POU2F1: POU domain, class 2, transcription factor 1
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
STTTCRNTTT_V$IRF_Q6
Genes with promoter regions [-2kb,2kb] around transcription start site containing motif STTTCRNTTT. Motif does not match any known transcription factor
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
TGACCTY_V$ERR1_Q2
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCTY which matches annotation for ESRRA: estrogen-related receptor alpha
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
TGGAAA_V$NFAT_Q4_01
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGGAAA which matches annotation for NFAT<br> NFATC
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$EVI1_04
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif DGATADGAHWAGATA which matches annotation for EVI1: ecotropic viral integration site 1
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$COUP_DR1_Q6
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCTTTGACCC which matches annotation for PITX2: paired-like homeodomain transcription factor 2
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
chr11q24
Genes in cytogenetic band chr11q24
c1 - Positional genesets for each human chromosome and cytogenetic band.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
TGACCTTG_V$SF1_Q6
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCTTG which matches annotation for SF1: splicing factor 1
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$MEIS1_01
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNTGACAGNNN which matches annotation for MEIS1: Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$SF1_Q6
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGRCCTTG which matches annotation for SF1: splicing factor 1
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
SMTTTTGT_UNKNOWN
Genes with promoter regions [-2kb,2kb] around transcription start site containing motif SMTTTTGT. Motif does not match any known transcription factor
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$IRF7_01
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TNSGAAWNCGAAANTNNN which matches annotation for IRF7: interferon regulatory factor 7
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$HNF4_Q6
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AARGTCCAN which matches annotation for HNF4A: hepatocyte nuclear factor 4, alpha
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$FOXJ2_02
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AYMATAATATTTKN which matches annotation for FOXJ2: forkhead box J2
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$HFH4_01
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AWKTGTTTGTTTA which matches annotation for FOXJ1: forkhead box J1
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
RGAGGAARY_V$PU1_Q6
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RGAGGAARY which matches annotation for SPI1: spleen focus forming virus (SFFV) proviral integration oncogene spi1
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$NFAT_Q4_01
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NWGGAAANWN which matches annotation for NFAT<br> NFATC
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
V$ERR1_Q2
Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNTNAAGGTCANN which matches annotation for ESRRA: estrogen-related receptor alpha
c3 - Motif genesets based on conserved cis-regulatory motifs from a comparative analysis of the human, mouse, rat, and dog genomes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "V$MEIS1_01" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is TRANSFAC.
gene2pc v. 0.1.0
Last updated 2015.08.31
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "RGAGGAARY_V$PU1_Q6" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is TRANSFAC.
gene2pc v. 0.1.0
Last updated 2015.08.31
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "V$FOXJ2_02" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is TRANSFAC.
gene2pc v. 0.1.0
Last updated 2015.08.31
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "V$IRF7_01" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is TRANSFAC.
gene2pc v. 0.1.0
Last updated 2015.08.31
Authors:
None
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