List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Myeloproliferative neoplasms. The EFO term myeloproliferative disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
W Tapper, AV Jones, R Kralovics, AS Harutyunyan, K Zoi, W Leung, AL Godfrey, P Guglielmelli, A Callaway, D Ward, P Aranaz, HE White, K Waghorn, F Lin, A Chase, EJ Baxter, C Maclean, J Nangalia, E Chen, P Evans, M Short, A Jack, L Wallis, D Oscier, AS Duncombe, A Schuh, AJ Mead, M Griffiths, J Ewing, RE Gale, S Schnittger, T Haferlach, F Stegelmann, K Döhner, H Grallert, K Strauch, T Tanaka, S Bandinelli, A Giannopoulos, L Pieri, C Mannarelli, H Gisslinger, G Barosi, M Cazzola, A Reiter, C Harrison, P Campbell, AR Green, A Vannucchi, NC Cross
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Myeloproliferative neoplasms. The EFO term myeloproliferative disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
O Kilpivaara, S Mukherjee, AM Schram, M Wadleigh, A Mullally, BL Ebert, A Bass, S Marubayashi, A Heguy, G Garcia-Manero, H Kantarjian, K Offit, RM Stone, DG Gilliland, RJ Klein, RL Levine
"The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:jl, PMID:12479803]
"The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:jl, PMID:12479803]
"Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
"Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
"Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
"Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Generated by gene2mesh v. 1.1.1
Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Ulcerative colitis. The EFO term ulcerative colitis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
CA Anderson, G Boucher, CW Lees, A Franke, M D'Amato, KD Taylor, JC Lee, P Goyette, M Imielinski, A Latiano, C Lagacé, R Scott, L Amininejad, S Bumpstead, L Baidoo, RN Baldassano, M Barclay, TM Bayless, S Brand, C Büning, JF Colombel, LA Denson, M De Vos, M Dubinsky, C Edwards, D Ellinghaus, RS Fehrmann, JA Floyd, T Florin, D Franchimont, L Franke, M Georges, J Glas, NL Glazer, SL Guthery, T Haritunians, NK Hayward, JP Hugot, G Jobin, D Laukens, I Lawrance, M Lémann, A Levine, C Libioulle, E Louis, DP McGovern, M Milla, GW Montgomery, KI Morley, C Mowat, A Ng, W Newman, RA Ophoff, L Papi, O Palmieri, L Peyrin-Biroulet, J Panés, A Phillips, NJ Prescott, DD Proctor, R Roberts, R Russell, P Rutgeerts, J Sanderson, M Sans, P Schumm, F Seibold, Y Sharma, LA Simms, M Seielstad, AH Steinhart, SR Targan, LH van den Berg, M Vatn, H Verspaget, T Walters, C Wijmenga, DC Wilson, HJ Westra, RJ Xavier, ZZ Zhao, CY Ponsioen, V Andersen, L Torkvist, M Gazouli, NP Anagnou, TH Karlsen, L Kupcinskas, J Sventoraityte, JC Mansfield, S Kugathasan, MS Silverberg, J Halfvarson, JI Rotter, CG Mathew, AM Griffiths, R Gearry, T Ahmad, SR Brant, M Chamaillard, J Satsangi, JH Cho, S Schreiber, MJ Daly, JC Barrett, M Parkes, V Annese, H Hakonarson, G Radford-Smith, RH Duerr, S Vermeire, RK Weersma, JD Rioux
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Crohn's disease. The EFO term Crohn's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JC Barrett, S Hansoul, DL Nicolae, JH Cho, RH Duerr, JD Rioux, SR Brant, MS Silverberg, KD Taylor, MM Barmada, A Bitton, T Dassopoulos, LW Datta, T Green, AM Griffiths, EO Kistner, MT Murtha, MD Regueiro, JI Rotter, LP Schumm, AH Steinhart, SR Targan, RJ Xavier, C Libioulle, C Sandor, M Lathrop, J Belaiche, O Dewit, I Gut, S Heath, D Laukens, M Mni, P Rutgeerts, A Van Gossum, D Zelenika, D Franchimont, JP Hugot, M de Vos, S Vermeire, E Louis, LR Cardon, CA Anderson, H Drummond, E Nimmo, T Ahmad, NJ Prescott, CM Onnie, SA Fisher, J Marchini, J Ghori, S Bumpstead, R Gwilliam, M Tremelling, P Deloukas, J Mansfield, D Jewell, J Satsangi, CG Mathew, M Parkes, M Georges, MJ Daly
Cerebellum Gene Expression Correlates for HARGREAVES_MEANBOTH measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The HARGREAVES_MEANBOTH measures Thermal Nociception Hargreaves' Test under the domain Pain. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for LM_CUE_SUPPRESS measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The LM_CUE_SUPPRESS measures Suppression of activity in altered context under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for COCA_BASE_VEHICLE measured in BXD RI Females & Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The COCA_BASE_VEHICLE measures CPP- Time (s) spent in saline paired compartment a under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Analyzed 45 single nucleotide polymorphisms, tagging 29 of the loci recently associated with CD in 2527 UC cases and 4070 population controls. We also genotyped the UC-associated ECM1 variant rs11205387 in 1560 CD patients and 3028 controls.
Authors:
Waller S, Tremelling M, Bredin F, Godfrey L, Howson J, Parkes M
Top tier were previously reported at genome-wide significance (5×10−8), bottom tier were previously reported with weaker evidence. P values are one-tailed in the direction of the previously reported association.
Authors:
Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Barrett JC, Bellenguez C, Davison D, Freeman C, Strange A, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Deloukas P, Peltonen L, Mathew CG, Blackwell JM, Brown MA, Corvin A, McCarthy MI, Spencer CC, Attwood AP, Stephens J, Sambrook J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP
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