List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Immunoglobulin A. The EFO term protein measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
RC Ferreira, Q Pan-Hammarström, RR Graham, V Gateva, G Fontán, AT Lee, W Ortmann, E Urcelay, M Fernández-Arquero, C Núñez, G Jorgensen, BR Ludviksson, S Koskinen, K Haimila, HF Clark, L Klareskog, PK Gregersen, TW Behrens, L Hammarström
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Psoriasis vulgaris. The EFO term psoriasis vulgaris was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
PE Stuart, RP Nair, LC Tsoi, T Tejasvi, S Das, HM Kang, E Ellinghaus, V Chandran, K Callis-Duffin, R Ike, Y Li, X Wen, C Enerbäck, JE Gudjonsson, S Kõks, K Kingo, T Esko, U Mrowietz, A Reis, HE Wichmann, C Gieger, P Hoffmann, MM Nöthen, J Winkelmann, M Kunz, EG Moreta, PJ Mease, CT Ritchlin, AM Bowcock, GG Krueger, HW Lim, S Weidinger, M Weichenthal, JJ Voorhees, P Rahman, PK Gregersen, A Franke, DD Gladman, GR Abecasis, JT Elder
In this AAV association study, eight of the ten regions tested did not show an AAV association, with P values between 0.19 and 0.75 (table 1). Genotypes for all SNPs did not significantly deviate from Hardy-Weinberg equi- librium in either cases or controls.
Authors:
Carr EJ, Niederer HA, Williams J, Harper L, Watts RA, Lyons PA, Smith KG
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Psoriasis. The EFO term psoriasis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
X Yin, HQ Low, L Wang, Y Li, E Ellinghaus, J Han, X Estivill, L Sun, X Zuo, C Shen, C Zhu, A Zhang, F Sanchez, L Padyukov, JJ Catanese, GG Krueger, KC Duffin, S Mucha, M Weichenthal, S Weidinger, W Lieb, JN Foo, Y Li, K Sim, H Liany, I Irwan, Y Teo, CT Theng, R Gupta, A Bowcock, PL De Jager, AA Qureshi, PI de Bakker, M Seielstad, W Liao, M Ståhle, A Franke, X Zhang, J Liu
GWAS: type I diabetes mellitus, autoantibody measurement
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 1 diabetes autoantibodies. The EFO term type I diabetes mellitus, autoantibody measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
V Plagnol, JM Howson, DJ Smyth, N Walker, JP Hafler, C Wallace, H Stevens, L Jackson, MJ Simmonds, PJ Bingley, SC Gough, JA Todd
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Vitiligo. The EFO term Vitiligo was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Jin, SA Birlea, PR Fain, TM Ferrara, S Ben, SL Riccardi, JB Cole, K Gowan, PJ Holland, DC Bennett, RM Luiten, A Wolkerstorfer, JP van der Veen, A Hartmann, S Eichner, G Schuler, N van Geel, J Lambert, EH Kemp, DJ Gawkrodger, AP Weetman, A Taïeb, T Jouary, K Ezzedine, MR Wallace, WT McCormack, M Picardo, G Leone, A Overbeck, NB Silverberg, RA Spritz
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Psoriasis. The EFO term psoriasis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Strange, F Capon, CC Spencer, J Knight, ME Weale, MH Allen, A Barton, G Band, C Bellenguez, JG Bergboer, JM Blackwell, E Bramon, SJ Bumpstead, JP Casas, MJ Cork, A Corvin, P Deloukas, A Dilthey, A Duncanson, S Edkins, X Estivill, O Fitzgerald, C Freeman, E Giardina, E Gray, A Hofer, U Hüffmeier, SE Hunt, AD Irvine, J Jankowski, B Kirby, C Langford, J Lascorz, J Leman, S Leslie, L Mallbris, HS Markus, CG Mathew, WH McLean, R McManus, R Mössner, L Moutsianas, AT Naluai, FO Nestle, G Novelli, A Onoufriadis, CN Palmer, C Perricone, M Pirinen, R Plomin, SC Potter, RM Pujol, A Rautanen, E Riveira-Munoz, AW Ryan, W Salmhofer, L Samuelsson, SJ Sawcer, J Schalkwijk, CH Smith, M Ståhle, Z Su, R Tazi-Ahnini, H Traupe, AC Viswanathan, RB Warren, W Weger, K Wolk, N Wood, J Worthington, HS Young, PL Zeeuwen, A Hayday, AD Burden, CE Griffiths, J Kere, A Reis, G McVean, DM Evans, MA Brown, JN Barker, L Peltonen, P Donnelly, RC Trembath
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "MDA-5 signaling pathway", which is defined as "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "cytoplasmic pattern recognition receptor signaling pathway in response to virus", which is defined as "Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cutaneous psoriasis. The EFO term cutaneous psoriasis measurement, psoriasis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
PE Stuart, RP Nair, LC Tsoi, T Tejasvi, S Das, HM Kang, E Ellinghaus, V Chandran, K Callis-Duffin, R Ike, Y Li, X Wen, C Enerbäck, JE Gudjonsson, S Kõks, K Kingo, T Esko, U Mrowietz, A Reis, HE Wichmann, C Gieger, P Hoffmann, MM Nöthen, J Winkelmann, M Kunz, EG Moreta, PJ Mease, CT Ritchlin, AM Bowcock, GG Krueger, HW Lim, S Weidinger, M Weichenthal, JJ Voorhees, P Rahman, PK Gregersen, A Franke, DD Gladman, GR Abecasis, JT Elder
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Psoriatic arthritis. The EFO term psoriatic arthritis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
PE Stuart, RP Nair, LC Tsoi, T Tejasvi, S Das, HM Kang, E Ellinghaus, V Chandran, K Callis-Duffin, R Ike, Y Li, X Wen, C Enerbäck, JE Gudjonsson, S Kõks, K Kingo, T Esko, U Mrowietz, A Reis, HE Wichmann, C Gieger, P Hoffmann, MM Nöthen, J Winkelmann, M Kunz, EG Moreta, PJ Mease, CT Ritchlin, AM Bowcock, GG Krueger, HW Lim, S Weidinger, M Weichenthal, JJ Voorhees, P Rahman, PK Gregersen, A Franke, DD Gladman, GR Abecasis, JT Elder
Neocortex Gene Expression Correlates for NEINVCOUNT15 measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NEINVCOUNT15 measures Novel environment rears 0-15 min in the center under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
The concept of susceptibility genes common to different autoimmune diseases is now firmly established with previous studies demonstrating overlap of loci conferring susceptibility to type 1 diabetes (T1D) with both Coeliac disease and multiple sclerosis. Rheumatoid arthritis (RA) is an archetypal autoimmune disease and we, therefore, targeted putative T1D susceptibility loci for genotyping in UK RA cases and unrelated controls.
Authors:
Barton A, Eyre S, Ke X, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Thomson W, Worthington J
QTL for METH responses for climbing on Chr2 at Brp13 (41.42 Mbp , Build 37)
Description:
METH responses for climbing spans 16.42 - 66.42 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol consumption on Chr2 at D2Mit7 (47.24 Mbp , Build 37)
Description:
ethanol consumption spans 22.24 - 72.24 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol preference on Chr2 at D2Mit61 (59.53 Mbp , Build 37)
Description:
alcohol preference spans 34.53 - 84.53 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for chewing on Chr2 at Hoxd (60.63 Mbp , Build 37)
Description:
METH responses for chewing spans 35.63 - 85.63 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol preference locus on Chr2 at NA (63.74 Mbp , Build 37)
Description:
alcohol preference locus spans 38.74 - 88.74 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol withdrawal on Chr2 at D2Mit9 (63.74 Mbp , Build 37)
Description:
alcohol withdrawal spans 38.74 - 88.74 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for activity response to ethanol on Chr2 at NA (80.10 Mbp , Build 37)
Description:
activity response to ethanol spans 55.10 - 105.10 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol response acute on Chr2 at NA (80.10 Mbp , Build 37)
Description:
ethanol response acute spans 55.10 - 105.10 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Demarest K, McCaughran J Jr, Mahjubi E, Cipp L, Hitzemann R
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