Study analyzed 812 differentially expressed gene candidates from peripheral blood mononuclear cells (PBMC) from morphine and saline treated rats, and suggests similarities between the gene expression profile in PBMCs and in the brain of morphine-treated rats. This set contains the 79 genes implicated by this study to modulate expression during chronic morphine treatment.
Authors:
Desjardins S, Belkai E, Crete D, Cordonnier L, Scherrmann JM, Noble F, Marie-Claire C
32 genes differentially expressed in the 11-week old C57BL/6J male mouse ventral striatum following oxycodone self-administration based on RNA-seq data. The first five genes in this GeneSet are ones displaying experiment-wise significant changes in RNA levels; the remaining show point-wise significance. Data were taken from Table 1. Values presented are p-adjusted values.
GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
7 genes differentially expressed in the 11-week old C57BL/6J male mouse dorsal striatum following oxycodone self-administration based on RNA-seq data. Values presented are p-adjusted values. Data were taken from Table 2. GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
Statistical analysis of the 224 reward-related genes differentially expressed in the 11-week old C57BL/6J male mouse ventral striatum following oxycodone self-administration based on RNA-seq data. Values presented are p-adjusted values. Note: genes with a p-adjusted value of "NA" were excluded. Data were take from Table 6. GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Parkinson disease and lewy body pathology. The EFO term Parkinson's disease, Lewy body measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
GW Beecham, DW Dickson, WK Scott, ER Martin, G Schellenberg, K Nuytemans, EB Larson, JD Buxbaum, JQ Trojanowski, VM Van Deerlin, HI Hurtig, DC Mash, TG Beach, JC Troncoso, O Pletnikova, MP Frosch, B Ghetti, TM Foroud, LS Honig, K Marder, JP Vonsattel, SM Goldman, HV Vinters, OA Ross, ZK Wszolek, L Wang, DM Dykxhoorn, MA Pericak-Vance, TJ Montine, JB Leverenz, TM Dawson, JM Vance
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Addiction related genes identified in literature review. One or more variants have been associated with one or more addictions. Genes associated with Addiction, impulsivity, Environment, Strees, Heroin or opiate, Alcohol, Cocaine or other stimulants are listed.
The nuclear accumbens (NA) and amygdale (Amyg) of inbred alcohol-preferring mice were examined for differential gene expression and it findings suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of ethanol (EtOH). This gene set comprises 201 genes that were significantly expressed in the NA during the experiment.
Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ
Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ
QTL for METH responses for home cage activity on Chr14 at Gnrh (75.38 Mbp , Build 37)
Description:
METH responses for home cage activity spans 50.38 - 100.38 Mbp (NCBI Build 37) on Chr14. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for chronic alcohol withdrawal severity on Chr14 at D14mit160 (75.81 Mbp , Build 37)
Description:
chronic alcohol withdrawal severity spans 50.81 - 100.81 Mbp (NCBI Build 37) on Chr14. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for METH responses for climbing on Chr14 at Es10 (78.19 Mbp , Build 37)
Description:
METH responses for climbing spans 53.19 - 103.19 Mbp (NCBI Build 37) on Chr14. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes associated with nan that interact with the MeSH term 'Benzamides' (D001549). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Arsenic' (D001151). Incorporates data from 87 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'tryptamine' (C030820). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Fluphenazine' (D005476). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Bos taurus that interact with the MeSH term 'Mianserin' (D008803). Incorporates data from 17 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with nan that interact with the MeSH term 'Spiperone' (D013134). Incorporates data from 14 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Paroxetine' (D017374). Incorporates data from 4 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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