Genes downregulated in livers of Eif2ak4(Gcn2)-mutant mice 30 minutes after perfusion with amino acids lacking methionine. Removing methionine induces amino-acid starvation. Sequences reported in the manuscript were used to search the MGI resource using the batch query form on June 15, 2018. Sequences that did not match were investigated manually. Sequences that were associated with putative assignments to gene identifiers were included. Values represent z-scores. Higher scores were used for genes represented more than once.
The GEO2R tool was used to analyze microarray data from mice either mock-infected or infected with SARS-CoV1. The Gene sets used in the analysis were from GSE59185. GEO2R was used with default parameters. Genes with an adjusted p-value of <0.05 and a log fold change <-1.0 are included in this set. EntrezGene identifiers or sequence identifiers were converted to MGI identifiers. Genes that could not be converted were omitted. If a gene was represented more than once, the largest fold-change was chosen.
Authors:
Jose A Regla-Nava, Jose L Nieto-Torres, Jose M Jimenez-Guardeño, Raul Fernandez-Delgado, Craig Fett, Carlos Castaño-Rodríguez, Stanley Perlman, Luis Enjuanes, Marta L DeDiego
GeneWeaver