Acute and chronic alcohol exposure was analyzed in 534 (C57BL/6J x C3H/HeJ)F2 mice. Behavioral testing was done using 5 traits, acute drug effect, forced ethanol drinking, withdrawal studies ethanol preference and stress induced ethanol drinking. The following QTL were found in a genome wide scan: Following the QTL is the Chromosome , cM location, and LOD score, Eih1 (Chr 1, 85 cM, LOD 6.6), Eih2 (Chr 7, 10 cM, LOD 3.6), Ceih1 (Chr 3, 55 cM, LOD 4.1), Ceih2 (Chr 6, 24.7 cM, LOD 4.1), Ceih3 (Chr 13, 39 cM, LOD 4.1), Eia1(Chr 1, 65 cM, LOD 10.3 and 10.4), Eiwa1 (Chr 7, 50 cM, LOD 4.4), Eiwa2(Chr 11, 43.1 cM, LOD 4.1),Aldd1(Chr 5, 42 cM, LOD 13.2), Aldd2(Chr 12, 18 cM, LOD 5.3),Eiwax1(Chr 1, 79 cM, LOD 6.5), Eiwax2(Chr 5, 59 cM, LOD 15.0), Eiwax3(Chr 12, 21 cM, LOD 3.6), Methp1(Chr 16, 31.4 cM, LOD 4.3), Mec1(Chr 16, 19.4 cM, LOD 5.1), Epbs1(Chr 16, 33 cM, LOD 4.1), Ecbs1(Chr 16, 29.4 cM, LOD 4.8), Mec2(Chr 1, 109 cM, LOD 3.9), Mec3(Chr 2, 109 cM, LOD 4.3), Mec4(Chr 5, 29 cM, LOD 3.9), Mec5(Chr 10, 2 cM, LOD 5.0), Mec6(Chr 15, 49 cM, LOD 5.2, 95% CI 6.7–56.7).
Authors:
Drews E, Rcz I, Lacava AD, Barth A, Bilkei-Gorz A, Wienker TF, Zimmer A
Ethanol Preference from BXD lines span 58586243-108586243. This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Marker Loci associated with 10% Ethanol Preferences Drinking at p<0.05 (Two Tailed) in the BXD RI set and the Correlation Coefficient, p and Estimated LOD. D15Mit33 (83586243 NCBI 37) p=0.05, LOD=0.08 overall LOD BXD & Select Line 2.4.
QTL for Voluntary Ethanol Consumption on LS x SS RI lines spans 43765164-93765164 .This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Chr 15 D15Mit3 39 cM VEC (females) 0.02
In the present study Aaq1, a previously mapped QTL on mouse Chromosome 15 linked to alcohol acceptance, is confirmed using a (C57BL/6J x DBA/2J)F2 population. Aaq1 mapped to 15 cM (D15Mit60)- 48 cM (D15Mit34) on mouse Chromosome 15 with a peak LOD score of 3.8 at approximately 30 cM. C57BL/6J-derived alleles confer increased alcohol acceptance in a dominant fashion at Aaq1. A potential candidate gene for Aaq1 is the peripheral benzodiazepine receptor gene, Bzrp.
Authors:
McClearn GE, Tarantino LM, Rodriguez LA, Jones BC, Blizard DA, Plomin R
QTL mapping results for B6D2F2 mice in regions provisionally identified in BXD RI mice for free-choice ethanol consumption. Peak D15Mit33 58586243-108586243. This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org)
Genes with particular expression in the Primary somatosensory area, trunk, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Posterior parietal association areas. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior olfactory nucleus, dorsal part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior olfactory nucleus, external part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior olfactory nucleus, lateral part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Main olfactory bulb, granule layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Main olfactory bulb, inner plexiform layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Posterior parietal association areas, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Posterior parietal association areas, layer 6b. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anteromedial visual area, layer 4. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anteromedial visual area, layer 5. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Main olfactory bulb. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Nucleus incertus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Posterior parietal association areas, layer 4. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Posterior parietal association areas, layer 5. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Posterolateral visual area, layer 4. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Folium-tuber vermis (VII), molecular layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, dorsal part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Primary somatosensory area, barrel field, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
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