Ethanol induced LORR Chr# 2 rs13476399(28144658) with right flanking marker rs3713997(3151175) and left marker rs3679483 (179861211). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with variability in response to cholestrol enriched atherogenic diet. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (8665223)
QTL associated with femoral cross-sectional area 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (24644623)
Authors:
Klein RF, Turner RJ, Skinner LD, Vartanian KA, Serang M, Carlos AS, Shea M, Belknap JK, Orwoll ES
QTL associated with induction of brown adipocytes 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20928232)
QTL associated with periosteal circumference and femur length 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25201804)
Authors:
Masinde GL, Wergedal J, Davidson H, Mohan S, Li R, Li X, Baylink DJ
QTL associated with pentylenetetrazol induced seizure susceptibility 1b. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25905794)
Authors:
Wakana S, Sugaya E, Naramoto F, Yokote N, Maruyama C, Jin W, Ohguchi H, Tsuda T, Sugaya A, Kajiwara K
QTL associated with voluntary alcohol consumption QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (9270167)
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
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