Any of the enzymatically catalyzed modifications of the individual AMINO ACIDS of PROTEINS, and enzymatic cleavage or crosslinking of peptide chains that occur pre-translationally (on the amino acid component of AMINO ACYL TRNA), co-translationally (during the process of GENETIC TRANSLATION), or after translation is completed (POST-TRANSLATIONAL PROTEIN PROCESSING).
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Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
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The chemical processes, enzymatic activities, and pathways of living things and related temporal, dimensional, qualitative, and quantitative concepts.
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Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
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The production of PEPTIDES or PROTEINS by the constituents of a living organism. The biosynthesis of proteins on RIBOSOMES following an RNA template is termed translation (TRANSLATION, GENETIC). There are other, non-ribosomal peptide biosynthesis (PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT) mechanisms carried out by PEPTIDE SYNTHASES and PEPTIDYLTRANSFERASES. Further modifications of peptide chains yield functional peptide and protein molecules.
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The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
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The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.
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The processes, properties and biological objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.
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The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
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The reactions and interactions of atoms and molecules, the changes in their structure and composition, and associated energy changes.
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The CHEMICAL PROCESSES that occur within the cells, tissues, or an organism and related temporal, spatial, qualitative, and quantitative concepts.
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The biological objects that contain genetic information and that are involved in transmitting genetically encoded traits from one organism to another.
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Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
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List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Mean corpuscular volume. The EFO term mean corpuscular volume was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
SK Ganesh, NA Zakai, FJ van Rooij, N Soranzo, AV Smith, MA Nalls, MH Chen, A Kottgen, NL Glazer, A Dehghan, B Kuhnel, T Aspelund, Q Yang, T Tanaka, A Jaffe, JC Bis, GC Verwoert, A Teumer, CS Fox, JM Guralnik, GB Ehret, K Rice, JF Felix, A Rendon, G Eiriksdottir, D Levy, KV Patel, E Boerwinkle, JI Rotter, A Hofman, JG Sambrook, DG Hernandez, G Zheng, S Bandinelli, AB Singleton, J Coresh, T Lumley, AG Uitterlinden, JM Vangils, LJ Launer, LA Cupples, BA Oostra, JJ Zwaginga, WH Ouwehand, SL Thein, C Meisinger, P Deloukas, M Nauck, TD Spector, C Gieger, V Gudnason, CM van Duijn, BM Psaty, L Ferrucci, A Chakravarti, A Greinacher, CJ O'Donnell, JC Witteman, S Furth, M Cushman, TB Harris, JP Lin
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Red blood cell traits. The EFO term mean corpuscular hemoglobin was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
P van der Harst, W Zhang, I Mateo Leach, A Rendon, N Verweij, J Sehmi, DS Paul, U Elling, H Allayee, X Li, A Radhakrishnan, ST Tan, K Voss, CX Weichenberger, CA Albers, A Al-Hussani, FW Asselbergs, M Ciullo, F Danjou, C Dina, T Esko, DM Evans, L Franke, M Gögele, J Hartiala, M Hersch, H Holm, JJ Hottenga, S Kanoni, ME Kleber, V Lagou, C Langenberg, LM Lopez, LP Lyytikäinen, O Melander, F Murgia, IM Nolte, PF O'Reilly, S Padmanabhan, A Parsa, N Pirastu, E Porcu, L Portas, I Prokopenko, JS Ried, SY Shin, CS Tang, A Teumer, M Traglia, S Ulivi, HJ Westra, J Yang, JH Zhao, F Anni, A Abdellaoui, A Attwood, B Balkau, S Bandinelli, F Bastardot, B Benyamin, BO Boehm, WO Cookson, D Das, PI de Bakker, RA de Boer, EJ de Geus, MH de Moor, M Dimitriou, FS Domingues, A Döring, G Engström, GI Eyjolfsson, L Ferrucci, K Fischer, R Galanello, SF Garner, B Genser, QD Gibson, G Girotto, DF Gudbjartsson, SE Harris, AL Hartikainen, CE Hastie, B Hedblad, T Illig, J Jolley, M Kähönen, IP Kema, JP Kemp, L Liang, H Lloyd-Jones, RJ Loos, S Meacham, SE Medland, C Meisinger, Y Memari, E Mihailov, K Miller, MF Moffatt, M Nauck, M Novatchkova, T Nutile, I Olafsson, PT Onundarson, D Parracciani, BW Penninx, L Perseu, A Piga, G Pistis, A Pouta, U Puc, O Raitakari, SM Ring, A Robino, D Ruggiero, A Ruokonen, A Saint-Pierre, C Sala, A Salumets, J Sambrook, H Schepers, CO Schmidt, HH Silljé, R Sladek, JH Smit, JM Starr, J Stephens, P Sulem, T Tanaka, U Thorsteinsdottir, V Tragante, WH van Gilst, LJ van Pelt, DJ van Veldhuisen, U Völker, JB Whitfield, G Willemsen, BR Winkelmann, G Wirnsberger, A Algra, F Cucca, AP d'Adamo, J Danesh, IJ Deary, AF Dominiczak, P Elliott, P Fortina, P Froguel, P Gasparini, A Greinacher, SL Hazen, MR Jarvelin, KT Khaw, T Lehtimäki, W Maerz, NG Martin, A Metspalu, BD Mitchell, GW Montgomery, C Moore, G Navis, M Pirastu, PP Pramstaller, R Ramirez-Solis, E Schadt, J Scott, AR Shuldiner, GD Smith, JG Smith, H Snieder, R Sorice, TD Spector, K Stefansson, M Stumvoll, WH Tang, D Toniolo, A Tönjes, PM Visscher, P Vollenweider, NJ Wareham, BH Wolffenbuttel, DI Boomsma, JS Beckmann, GV Dedoussis, P Deloukas, MA Ferreira, S Sanna, M Uda, AA Hicks, JM Penninger, C Gieger, JS Kooner, WH Ouwehand, N Soranzo, JC Chambers
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood trace element (Zn levels). The EFO term serum zinc measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
DM Evans, G Zhu, V Dy, AC Heath, PA Madden, JP Kemp, G McMahon, B St Pourcain, NJ Timpson, J Golding, DA Lawlor, C Steer, GW Montgomery, NG Martin, GD Smith, JB Whitfield
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
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