List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Atopic dermatitis. The EFO term atopic eczema was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
LD Sun, FL Xiao, Y Li, WM Zhou, HY Tang, XF Tang, H Zhang, H Schaarschmidt, XB Zuo, R Foelster-Holst, SM He, M Shi, Q Liu, YM Lv, XL Chen, KJ Zhu, YF Guo, DY Hu, M Li, M Li, YH Zhang, X Zhang, JP Tang, BR Guo, H Wang, Y Liu, XY Zou, FS Zhou, XY Liu, G Chen, L Ma, SM Zhang, AP Jiang, XD Zheng, XH Gao, P Li, CX Tu, XY Yin, XP Han, YQ Ren, SP Song, ZY Lu, XL Zhang, Y Cui, J Chang, M Gao, XY Luo, PG Wang, X Dai, W Su, H Li, CP Shen, SX Liu, XB Feng, CJ Yang, GS Lin, ZX Wang, JQ Huang, X Fan, Y Wang, YX Bao, S Yang, JJ Liu, A Franke, S Weidinger, ZR Yao, XJ Zhang
GWAS: childhood onset asthma, atopic eczema, atopic march
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Atopic march. The EFO term childhood onset asthma, atopic eczema, atopic march was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
I Marenholz, J Esparza-Gordillo, F Rüschendorf, A Bauerfeind, DP Strachan, BD Spycher, H Baurecht, P Margaritte-Jeannin, A Sääf, M Kerkhof, M Ege, S Baltic, MC Matheson, J Li, S Michel, WQ Ang, W McArdle, A Arnold, G Homuth, F Demenais, E Bouzigon, C Söderhäll, G Pershagen, JC de Jongste, DS Postma, C Braun-Fahrländer, E Horak, LM Ogorodova, VP Puzyrev, EY Bragina, TJ Hudson, C Morin, DL Duffy, GB Marks, CF Robertson, GW Montgomery, B Musk, PJ Thompson, NG Martin, A James, P Sleiman, E Toskala, E Rodriguez, R Fölster-Holst, A Franke, W Lieb, C Gieger, A Heinzmann, E Rietschel, T Keil, S Cichon, MM Nöthen, CE Pennell, PD Sly, CO Schmidt, A Matanovic, V Schneider, M Heinig, N Hübner, PG Holt, S Lau, M Kabesch, S Weidinger, H Hakonarson, MA Ferreira, C Laprise, MB Freidin, J Genuneit, GH Koppelman, E Melén, MH Dizier, AJ Henderson, YA Lee
The chromosome 1 region has peak markers with of LOD of 3.45 and 3.46 for Alcoholism gender age and constraint as D1S2878 (165403366) D1S196 (167604128). Arbitrary interval of 25 MBp on each side of the peak makers was uploaded.
Authors:
Hill SY, Shen S, Zezza N, Hoffman EK, Perlin M, Allan W
chr1q21
Genes in cytogenetic band chr1q21
c1 - Positional genesets for each human chromosome and cytogenetic band.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
A group of pharmacologic activities, effects on living systems and the environment, and modes of employment of drugs and chemicals. They are broken into actions, which describe their effects, and uses, which describe how they are employed.
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A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
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Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
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Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
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The meaning ascribed to the BASE SEQUENCE with respect to how it is translated into AMINO ACID SEQUENCE. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons (CODON).
Generated by gene2mesh v. 1.1.1
The parts of a GENOME sequence that are involved with the different functions or properties of genomes as a whole as opposed to those of individual GENES.
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High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.
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The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
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Nucleic acid which complements a specific mRNA or DNA molecule, or fragment thereof; used for hybridization studies in order to identify microorganisms and for genetic studies.
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A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
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A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.
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The processes, properties and biological objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.
Generated by gene2mesh v. 1.1.1
A single chain of deoxyribonucleotides that occurs in some bacteria and viruses. It usually exists as a covalently closed circle.
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The three possible sequences of CODONS by which GENETIC TRANSLATION may occur from one nucleotide sequence. A segment of mRNA 5'AUCCGA3' could be translated as 5'AUC.. or 5'UCC.. or 5'CCG.., depending on the location of the START CODON.
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The biological objects that contain genetic information and that are involved in transmitting genetically encoded traits from one organism to another.
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Chemicals necessary to perform experimental and/or investigative procedures and for the preparation of drugs and other chemicals.
Generated by gene2mesh v. 1.1.1
Complex compounds of high molecular weight occurring in living cells. These are basically of two types, ribonucleic (RNA) and deoxyribonucleic (DNA) acids, both of which consist of nucleotides (nucleoside phosphates linked together by phosphate bridges).
Generated by gene2mesh v. 1.1.1
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Inflammatory skin disease. The EFO term atopic eczema was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
H Baurecht, M Hotze, S Brand, C Büning, P Cormican, A Corvin, D Ellinghaus, E Ellinghaus, J Esparza-Gordillo, R Fölster-Holst, A Franke, C Gieger, N Hubner, T Illig, AD Irvine, M Kabesch, YA Lee, W Lieb, I Marenholz, WH McLean, DW Morris, U Mrowietz, R Nair, MM Nöthen, N Novak, GM O'Regan, S Schreiber, C Smith, K Strauch, PE Stuart, R Trembath, LC Tsoi, M Weichenthal, J Barker, JT Elder, S Weidinger, HJ Cordell, SJ Brown
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