A polymerase chain reaction (PCR)-based method was used for detection of gene-promoter methylation, whereas genome-wide methylation analysis was performed using the Illumina Infinium Methylation Chip. Long-term shiftwork resulted in the same promoter hypomethylation of CLOCK and hypermethylation of CRY2, as was previously observed in breast cancer case-control studies. Genome-wide methylation analysis further discovered widespread methylation alterations in shiftworkers, including changes in many methylation- and cancer-relevant genes. Pathway analysis of the genes with altered methylation patterns revealed several cancer-related pathways. One of the top three networks generated was designated as “DNA replication, recombination, and repair, gene expression, behavior” with ESR1 (estrogen receptor α) featured most prominently in the network, underscoring the potential breast cancer relevance of the genes differentially methylated in long-term shiftworkers. These results, although exploratory, demonstrate the first evidence of the cancer-relevant epigenetic effects of night shiftwork, which warrant further investigation. Statistics reported as fold change.
Authors:
Zhu Y, Stevens RG, Hoffman AE, Tjonneland A, Vogel UB, Zheng T, Hansen J
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative). The EFO term triple-negative breast cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
KS Purrington, S Slager, D Eccles, D Yannoukakos, PA Fasching, P Miron, J Carpenter, J Chang-Claude, NG Martin, GW Montgomery, V Kristensen, H Anton-Culver, P Goodfellow, WJ Tapper, S Rafiq, SM Gerty, L Durcan, I Konstantopoulou, F Fostira, A Vratimos, P Apostolou, I Konstanta, V Kotoula, S Lakis, MA Dimopoulos, D Skarlos, D Pectasides, G Fountzilas, MW Beckmann, A Hein, M Ruebner, AB Ekici, A Hartmann, R Schulz-Wendtland, SP Renner, W Janni, B Rack, C Scholz, J Neugebauer, U Andergassen, MP Lux, L Haeberle, C Clarke, N Pathmanathan, A Rudolph, D Flesch-Janys, S Nickels, JE Olson, JN Ingle, C Olswold, S Slettedahl, JE Eckel-Passow, SK Anderson, DW Visscher, VL Cafourek, H Sicotte, N Prodduturi, E Weiderpass, L Bernstein, A Ziogas, J Ivanovich, GG Giles, L Baglietto, M Southey, VM Kosma, HP Fischer, MW Reed, SS Cross, S Deming-Halverson, M Shrubsole, Q Cai, XO Shu, M Daly, J Weaver, E Ross, J Klemp, P Sharma, D Torres, T Rüdiger, H Wölfing, HU Ulmer, A Försti, T Khoury, S Kumar, R Pilarski, CL Shapiro, D Greco, P Heikkilä, K Aittomäki, C Blomqvist, A Irwanto, J Liu, VS Pankratz, X Wang, G Severi, A Mannermaa, D Easton, P Hall, H Brauch, A Cox, W Zheng, AK Godwin, U Hamann, C Ambrosone, AE Toland, H Nevanlinna, CM Vachon, FJ Couch
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast cancer. The EFO term breast carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Long, Q Cai, H Sung, J Shi, B Zhang, JY Choi, W Wen, RJ Delahanty, W Lu, YT Gao, H Shen, SK Park, K Chen, CY Shen, Z Ren, CA Haiman, K Matsuo, MK Kim, US Khoo, M Iwasaki, Y Zheng, YB Xiang, K Gu, N Rothman, W Wang, Z Hu, Y Liu, KY Yoo, DY Noh, BG Han, MH Lee, H Zheng, L Zhang, PE Wu, YL Shieh, SY Chan, S Wang, X Xie, SW Kim, BE Henderson, L Le Marchand, H Ito, Y Kasuga, SH Ahn, HS Kang, KY Chan, H Iwata, S Tsugane, C Li, XO Shu, DH Kang, W Zheng
MORF_ESR1
Neighborhood of ESR1
c4 - Computational genesets defined by mining large collections of cancer-oriented microarray data.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone properties (heel). The EFO term velocity of sound measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Moayyeri, YH Hsu, D Karasik, K Estrada, SM Xiao, C Nielson, P Srikanth, S Giroux, SG Wilson, HF Zheng, AV Smith, SR Pye, PJ Leo, A Teumer, JY Hwang, C Ohlsson, F McGuigan, RL Minster, C Hayward, JM Olmos, LP Lyytikäinen, JR Lewis, KM Swart, L Masi, C Oldmeadow, EG Holliday, S Cheng, NM van Schoor, NC Harvey, M Kruk, F del Greco M, W Igl, O Trummer, E Grigoriou, R Luben, CT Liu, Y Zhou, L Oei, C Medina-Gomez, J Zmuda, G Tranah, SJ Brown, FM Williams, N Soranzo, J Jakobsdottir, K Siggeirsdottir, KL Holliday, A Hannemann, MJ Go, M Garcia, O Polasek, M Laaksonen, K Zhu, AW Enneman, M McEvoy, R Peel, PC Sham, M Jaworski, Å Johansson, AA Hicks, P Pludowski, R Scott, RA Dhonukshe-Rutten, N van der Velde, M Kähönen, JS Viikari, H Sievänen, OT Raitakari, J González-Macías, JL Hernández, D Mellström, O Ljunggren, YS Cho, U Völker, M Nauck, G Homuth, H Völzke, R Haring, MA Brown, E McCloskey, GC Nicholson, R Eastell, JA Eisman, G Jones, IR Reid, EM Dennison, J Wark, S Boonen, D Vanderschueren, FC Wu, T Aspelund, JB Richards, D Bauer, A Hofman, KT Khaw, G Dedoussis, B Obermayer-Pietsch, U Gyllensten, PP Pramstaller, RS Lorenc, C Cooper, AW Kung, P Lips, M Alen, J Attia, ML Brandi, LC de Groot, T Lehtimäki, JA Riancho, H Campbell, Y Liu, TB Harris, K Akesson, M Karlsson, JY Lee, H Wallaschofski, EL Duncan, TW O'Neill, V Gudnason, TD Spector, F Rousseau, E Orwoll, SR Cummings, NJ Wareham, F Rivadeneira, AG Uitterlinden, RL Prince, DP Kiel, J Reeve, SK Kaptoge
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone properties (heel). The EFO term bone quantitative ultrasound measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Moayyeri, YH Hsu, D Karasik, K Estrada, SM Xiao, C Nielson, P Srikanth, S Giroux, SG Wilson, HF Zheng, AV Smith, SR Pye, PJ Leo, A Teumer, JY Hwang, C Ohlsson, F McGuigan, RL Minster, C Hayward, JM Olmos, LP Lyytikäinen, JR Lewis, KM Swart, L Masi, C Oldmeadow, EG Holliday, S Cheng, NM van Schoor, NC Harvey, M Kruk, F del Greco M, W Igl, O Trummer, E Grigoriou, R Luben, CT Liu, Y Zhou, L Oei, C Medina-Gomez, J Zmuda, G Tranah, SJ Brown, FM Williams, N Soranzo, J Jakobsdottir, K Siggeirsdottir, KL Holliday, A Hannemann, MJ Go, M Garcia, O Polasek, M Laaksonen, K Zhu, AW Enneman, M McEvoy, R Peel, PC Sham, M Jaworski, Å Johansson, AA Hicks, P Pludowski, R Scott, RA Dhonukshe-Rutten, N van der Velde, M Kähönen, JS Viikari, H Sievänen, OT Raitakari, J González-Macías, JL Hernández, D Mellström, O Ljunggren, YS Cho, U Völker, M Nauck, G Homuth, H Völzke, R Haring, MA Brown, E McCloskey, GC Nicholson, R Eastell, JA Eisman, G Jones, IR Reid, EM Dennison, J Wark, S Boonen, D Vanderschueren, FC Wu, T Aspelund, JB Richards, D Bauer, A Hofman, KT Khaw, G Dedoussis, B Obermayer-Pietsch, U Gyllensten, PP Pramstaller, RS Lorenc, C Cooper, AW Kung, P Lips, M Alen, J Attia, ML Brandi, LC de Groot, T Lehtimäki, JA Riancho, H Campbell, Y Liu, TB Harris, K Akesson, M Karlsson, JY Lee, H Wallaschofski, EL Duncan, TW O'Neill, V Gudnason, TD Spector, F Rousseau, E Orwoll, SR Cummings, NJ Wareham, F Rivadeneira, AG Uitterlinden, RL Prince, DP Kiel, J Reeve, SK Kaptoge
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone mineral density (spine). The EFO term spine bone mineral density was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
BH Mullin, JP Walsh, HF Zheng, SJ Brown, GL Surdulescu, C Curtis, G Breen, F Dudbridge, JB Richards, TD Spector, SG Wilson
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone mineral density (Ward's triangle area). The EFO term femoral neck bone mineral density was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
YF Pei, WZ Hu, R Hai, XY Wang, S Ran, Y Lin, H Shen, Q Tian, SF Lei, YH Zhang, CJ Papasian, HW Deng, L Zhang
GWAS: dense area measurement, mammographic density measurement
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Mammographic density (dense area). The EFO term dense area measurement, mammographic density measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
S Lindström, DJ Thompson, AD Paterson, J Li, GL Gierach, C Scott, J Stone, JA Douglas, I dos-Santos-Silva, P Fernandez-Navarro, J Verghase, P Smith, J Brown, R Luben, NJ Wareham, RJ Loos, JA Heit, VS Pankratz, A Norman, EL Goode, JM Cunningham, M deAndrade, RA Vierkant, K Czene, PA Fasching, L Baglietto, MC Southey, GG Giles, KP Shah, HP Chan, MA Helvie, AH Beck, NW Knoblauch, A Hazra, DJ Hunter, P Kraft, M Pollan, JD Figueroa, FJ Couch, JL Hopper, P Hall, DF Easton, NF Boyd, CM Vachon, RM Tamimi
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone mineral density. The EFO term bone density was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
L Paternoster, M Lorentzon, T Lehtimäki, J Eriksson, M Kähönen, O Raitakari, M Laaksonen, H Sievänen, J Viikari, LP Lyytikäinen, D Mellström, M Karlsson, O Ljunggren, E Grundberg, JP Kemp, A Sayers, M Nethander, DM Evans, L Vandenput, JH Tobias, C Ohlsson
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast cancer. The EFO term breast carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
L Fejerman, N Ahmadiyeh, D Hu, S Huntsman, KB Beckman, JL Caswell, K Tsung, EM John, G Torres-Mejia, L Carvajal-Carmona, MM Echeverry, AM Tuazon, C Ramirez, CR Gignoux, C Eng, E Gonzalez-Burchard, B Henderson, L Le Marchand, C Kooperberg, L Hou, I Agalliu, P Kraft, S Lindström, EJ Perez-Stable, CA Haiman, E Ziv
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast cancer. The EFO term breast carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
W Zheng, J Long, YT Gao, C Li, Y Zheng, YB Xiang, W Wen, S Levy, SL Deming, JL Haines, K Gu, AM Fair, Q Cai, W Lu, XO Shu
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone mineral density (spine). The EFO term spine bone mineral density was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
HJ Choi, H Park, L Zhang, JH Kim, YA Kim, JY Yang, YF Pei, Q Tian, H Shen, JY Hwang, HW Deng, NH Cho, S Shin
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone mineral density (hip). The EFO term bone density was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
F Rivadeneira, U Styrkársdottir, K Estrada, BV Halldórsson, YH Hsu, JB Richards, MC Zillikens, FK Kavvoura, N Amin, YS Aulchenko, LA Cupples, P Deloukas, S Demissie, E Grundberg, A Hofman, A Kong, D Karasik, JB van Meurs, B Oostra, T Pastinen, HA Pols, G Sigurdsson, N Soranzo, G Thorleifsson, U Thorsteinsdottir, FM Williams, SG Wilson, Y Zhou, SH Ralston, CM van Duijn, T Spector, DP Kiel, K Stefansson, JP Ioannidis, AG Uitterlinden
Neocortex Gene Expression Correlates for LD_PCT_DISTLIGHT measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The LD_PCT_DISTLIGHT measures Light-Dark Box Percentage of distance traveled in light compartment under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for LD_PCT_LIGHT_TIME measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The LD_PCT_LIGHT_TIME measures Light-Dark Box Percentage time in light under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Hippocampus Gene Expression Correlates for HAND_4HOURS measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The HAND_4HOURS measures Handling induced convulsions 4 hrs after ethanol under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for LD_DARK_TIME measured in BXD RI Females & Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The LD_DARK_TIME measures Light-Dark Box Total seconds spent in dark compartment under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
GeneWeaver