List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term mean arterial pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
LV Wain, GC Verwoert, PF O'Reilly, G Shi, T Johnson, AD Johnson, M Bochud, KM Rice, P Henneman, AV Smith, GB Ehret, N Amin, MG Larson, V Mooser, D Hadley, M Dörr, JC Bis, T Aspelund, T Esko, AC Janssens, JH Zhao, S Heath, M Laan, J Fu, G Pistis, J Luan, P Arora, G Lucas, N Pirastu, I Pichler, AU Jackson, RJ Webster, F Zhang, JF Peden, H Schmidt, T Tanaka, H Campbell, W Igl, Y Milaneschi, JJ Hottenga, V Vitart, DI Chasman, S Trompet, JL Bragg-Gresham, BZ Alizadeh, JC Chambers, X Guo, T Lehtimäki, B Kühnel, LM Lopez, O Polašek, M Boban, CP Nelson, AC Morrison, V Pihur, SK Ganesh, A Hofman, S Kundu, FU Mattace-Raso, F Rivadeneira, EJ Sijbrands, AG Uitterlinden, SJ Hwang, RS Vasan, TJ Wang, S Bergmann, P Vollenweider, G Waeber, J Laitinen, A Pouta, P Zitting, WL McArdle, HK Kroemer, U Völker, H Völzke, NL Glazer, KD Taylor, TB Harris, H Alavere, T Haller, A Keis, ML Tammesoo, Y Aulchenko, I Barroso, KT Khaw, P Galan, S Hercberg, M Lathrop, S Eyheramendy, E Org, S Sõber, X Lu, IM Nolte, BW Penninx, T Corre, C Masciullo, C Sala, L Groop, BF Voight, O Melander, CJ O'Donnell, V Salomaa, AP d'Adamo, A Fabretto, F Faletra, S Ulivi, F Del Greco, M Facheris, FS Collins, RN Bergman, JP Beilby, J Hung, AW Musk, M Mangino, SY Shin, N Soranzo, H Watkins, A Goel, A Hamsten, P Gider, M Loitfelder, M Zeginigg, D Hernandez, SS Najjar, P Navarro, SH Wild, AM Corsi, A Singleton, EJ de Geus, G Willemsen, AN Parker, LM Rose, B Buckley, D Stott, M Orru, M Uda, MM van der Klauw, W Zhang, X Li, J Scott, YD Chen, GL Burke, M Kähönen, J Viikari, A Döring, T Meitinger, G Davies, JM Starr, V Emilsson, A Plump, JH Lindeman, PA Hoen, IR König, JF Felix, R Clarke, JC Hopewell, H Ongen, M Breteler, S Debette, AL Destefano, M Fornage, GF Mitchell, NL Smith, H Holm, K Stefansson, G Thorleifsson, U Thorsteinsdottir, NJ Samani, M Preuss, I Rudan, C Hayward, IJ Deary, HE Wichmann, OT Raitakari, W Palmas, JS Kooner, RP Stolk, JW Jukema, AF Wright, DI Boomsma, S Bandinelli, UB Gyllensten, JF Wilson, L Ferrucci, R Schmidt, M Farrall, TD Spector, LJ Palmer, J Tuomilehto, A Pfeufer, P Gasparini, D Siscovick, D Altshuler, RJ Loos, D Toniolo, H Snieder, C Gieger, P Meneton, NJ Wareham, BA Oostra, A Metspalu, L Launer, R Rettig, DP Strachan, JS Beckmann, JC Witteman, J Erdmann, KW van Dijk, E Boerwinkle, M Boehnke, PM Ridker, MR Jarvelin, A Chakravarti, GR Abecasis, V Gudnason, C Newton-Cheh, D Levy, PB Munroe, BM Psaty, MJ Caulfield, DC Rao, MD Tobin, P Elliott, CM van Duijn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term pulse pressure measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
LV Wain, GC Verwoert, PF O'Reilly, G Shi, T Johnson, AD Johnson, M Bochud, KM Rice, P Henneman, AV Smith, GB Ehret, N Amin, MG Larson, V Mooser, D Hadley, M Dörr, JC Bis, T Aspelund, T Esko, AC Janssens, JH Zhao, S Heath, M Laan, J Fu, G Pistis, J Luan, P Arora, G Lucas, N Pirastu, I Pichler, AU Jackson, RJ Webster, F Zhang, JF Peden, H Schmidt, T Tanaka, H Campbell, W Igl, Y Milaneschi, JJ Hottenga, V Vitart, DI Chasman, S Trompet, JL Bragg-Gresham, BZ Alizadeh, JC Chambers, X Guo, T Lehtimäki, B Kühnel, LM Lopez, O Polašek, M Boban, CP Nelson, AC Morrison, V Pihur, SK Ganesh, A Hofman, S Kundu, FU Mattace-Raso, F Rivadeneira, EJ Sijbrands, AG Uitterlinden, SJ Hwang, RS Vasan, TJ Wang, S Bergmann, P Vollenweider, G Waeber, J Laitinen, A Pouta, P Zitting, WL McArdle, HK Kroemer, U Völker, H Völzke, NL Glazer, KD Taylor, TB Harris, H Alavere, T Haller, A Keis, ML Tammesoo, Y Aulchenko, I Barroso, KT Khaw, P Galan, S Hercberg, M Lathrop, S Eyheramendy, E Org, S Sõber, X Lu, IM Nolte, BW Penninx, T Corre, C Masciullo, C Sala, L Groop, BF Voight, O Melander, CJ O'Donnell, V Salomaa, AP d'Adamo, A Fabretto, F Faletra, S Ulivi, F Del Greco, M Facheris, FS Collins, RN Bergman, JP Beilby, J Hung, AW Musk, M Mangino, SY Shin, N Soranzo, H Watkins, A Goel, A Hamsten, P Gider, M Loitfelder, M Zeginigg, D Hernandez, SS Najjar, P Navarro, SH Wild, AM Corsi, A Singleton, EJ de Geus, G Willemsen, AN Parker, LM Rose, B Buckley, D Stott, M Orru, M Uda, MM van der Klauw, W Zhang, X Li, J Scott, YD Chen, GL Burke, M Kähönen, J Viikari, A Döring, T Meitinger, G Davies, JM Starr, V Emilsson, A Plump, JH Lindeman, PA Hoen, IR König, JF Felix, R Clarke, JC Hopewell, H Ongen, M Breteler, S Debette, AL Destefano, M Fornage, GF Mitchell, NL Smith, H Holm, K Stefansson, G Thorleifsson, U Thorsteinsdottir, NJ Samani, M Preuss, I Rudan, C Hayward, IJ Deary, HE Wichmann, OT Raitakari, W Palmas, JS Kooner, RP Stolk, JW Jukema, AF Wright, DI Boomsma, S Bandinelli, UB Gyllensten, JF Wilson, L Ferrucci, R Schmidt, M Farrall, TD Spector, LJ Palmer, J Tuomilehto, A Pfeufer, P Gasparini, D Siscovick, D Altshuler, RJ Loos, D Toniolo, H Snieder, C Gieger, P Meneton, NJ Wareham, BA Oostra, A Metspalu, L Launer, R Rettig, DP Strachan, JS Beckmann, JC Witteman, J Erdmann, KW van Dijk, E Boerwinkle, M Boehnke, PM Ridker, MR Jarvelin, A Chakravarti, GR Abecasis, V Gudnason, C Newton-Cheh, D Levy, PB Munroe, BM Psaty, MJ Caulfield, DC Rao, MD Tobin, P Elliott, CM van Duijn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systolic blood pressure. The EFO term systolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
D Levy, GB Ehret, K Rice, GC Verwoert, LJ Launer, A Dehghan, NL Glazer, AC Morrison, AD Johnson, T Aspelund, Y Aulchenko, T Lumley, A Köttgen, RS Vasan, F Rivadeneira, G Eiriksdottir, X Guo, DE Arking, GF Mitchell, FU Mattace-Raso, AV Smith, K Taylor, RB Scharpf, SJ Hwang, EJ Sijbrands, J Bis, TB Harris, SK Ganesh, CJ O'Donnell, A Hofman, JI Rotter, J Coresh, EJ Benjamin, AG Uitterlinden, G Heiss, CS Fox, JC Witteman, E Boerwinkle, TJ Wang, V Gudnason, MG Larson, A Chakravarti, BM Psaty, CM van Duijn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hypertension. The EFO term hypertension was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
D Levy, GB Ehret, K Rice, GC Verwoert, LJ Launer, A Dehghan, NL Glazer, AC Morrison, AD Johnson, T Aspelund, Y Aulchenko, T Lumley, A Köttgen, RS Vasan, F Rivadeneira, G Eiriksdottir, X Guo, DE Arking, GF Mitchell, FU Mattace-Raso, AV Smith, K Taylor, RB Scharpf, SJ Hwang, EJ Sijbrands, J Bis, TB Harris, SK Ganesh, CJ O'Donnell, A Hofman, JI Rotter, J Coresh, EJ Benjamin, AG Uitterlinden, G Heiss, CS Fox, JC Witteman, E Boerwinkle, TJ Wang, V Gudnason, MG Larson, A Chakravarti, BM Psaty, CM van Duijn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Diastolic blood pressure. The EFO term diastolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
D Levy, GB Ehret, K Rice, GC Verwoert, LJ Launer, A Dehghan, NL Glazer, AC Morrison, AD Johnson, T Aspelund, Y Aulchenko, T Lumley, A Köttgen, RS Vasan, F Rivadeneira, G Eiriksdottir, X Guo, DE Arking, GF Mitchell, FU Mattace-Raso, AV Smith, K Taylor, RB Scharpf, SJ Hwang, EJ Sijbrands, J Bis, TB Harris, SK Ganesh, CJ O'Donnell, A Hofman, JI Rotter, J Coresh, EJ Benjamin, AG Uitterlinden, G Heiss, CS Fox, JC Witteman, E Boerwinkle, TJ Wang, V Gudnason, MG Larson, A Chakravarti, BM Psaty, CM van Duijn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Serum vitamin D-binding protein levels. The EFO term vitamin D-binding protein measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
KA Moy, AM Mondul, H Zhang, SJ Weinstein, W Wheeler, CC Chung, S Männistö, K Yu, SJ Chanock, D Albanes
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term mean arterial pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Simino, G Shi, JC Bis, DI Chasman, GB Ehret, X Gu, X Guo, SJ Hwang, E Sijbrands, AV Smith, GC Verwoert, JL Bragg-Gresham, G Cadby, P Chen, CY Cheng, T Corre, RA de Boer, A Goel, T Johnson, CC Khor, C LluÃs-Ganella, J Luan, LP Lyytikäinen, IM Nolte, X Sim, S Sõber, PJ van der Most, N Verweij, JH Zhao, N Amin, E Boerwinkle, C Bouchard, A Dehghan, G Eiriksdottir, R Elosua, OH Franco, C Gieger, TB Harris, S Hercberg, A Hofman, AL James, AD Johnson, M Kähönen, KT Khaw, Z Kutalik, MG Larson, LJ Launer, G Li, J Liu, K Liu, AC Morrison, G Navis, RT Ong, GJ Papanicolau, BW Penninx, BM Psaty, LJ Raffel, OT Raitakari, K Rice, F Rivadeneira, LM Rose, S Sanna, RA Scott, DS Siscovick, RP Stolk, AG Uitterlinden, D Vaidya, MM van der Klauw, RS Vasan, EN Vithana, U Völker, H Völzke, H Watkins, TL Young, T Aung, M Bochud, M Farrall, CA Hartman, M Laan, EG Lakatta, T Lehtimäki, RJ Loos, G Lucas, P Meneton, LJ Palmer, R Rettig, H Snieder, ES Tai, YY Teo, P van der Harst, NJ Wareham, C Wijmenga, TY Wong, M Fornage, V Gudnason, D Levy, W Palmas, PM Ridker, JI Rotter, CM van Duijn, JC Witteman, A Chakravarti, DC Rao
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term systolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Simino, G Shi, JC Bis, DI Chasman, GB Ehret, X Gu, X Guo, SJ Hwang, E Sijbrands, AV Smith, GC Verwoert, JL Bragg-Gresham, G Cadby, P Chen, CY Cheng, T Corre, RA de Boer, A Goel, T Johnson, CC Khor, C LluÃs-Ganella, J Luan, LP Lyytikäinen, IM Nolte, X Sim, S Sõber, PJ van der Most, N Verweij, JH Zhao, N Amin, E Boerwinkle, C Bouchard, A Dehghan, G Eiriksdottir, R Elosua, OH Franco, C Gieger, TB Harris, S Hercberg, A Hofman, AL James, AD Johnson, M Kähönen, KT Khaw, Z Kutalik, MG Larson, LJ Launer, G Li, J Liu, K Liu, AC Morrison, G Navis, RT Ong, GJ Papanicolau, BW Penninx, BM Psaty, LJ Raffel, OT Raitakari, K Rice, F Rivadeneira, LM Rose, S Sanna, RA Scott, DS Siscovick, RP Stolk, AG Uitterlinden, D Vaidya, MM van der Klauw, RS Vasan, EN Vithana, U Völker, H Völzke, H Watkins, TL Young, T Aung, M Bochud, M Farrall, CA Hartman, M Laan, EG Lakatta, T Lehtimäki, RJ Loos, G Lucas, P Meneton, LJ Palmer, R Rettig, H Snieder, ES Tai, YY Teo, P van der Harst, NJ Wareham, C Wijmenga, TY Wong, M Fornage, V Gudnason, D Levy, W Palmas, PM Ridker, JI Rotter, CM van Duijn, JC Witteman, A Chakravarti, DC Rao
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term pulse pressure measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Simino, G Shi, JC Bis, DI Chasman, GB Ehret, X Gu, X Guo, SJ Hwang, E Sijbrands, AV Smith, GC Verwoert, JL Bragg-Gresham, G Cadby, P Chen, CY Cheng, T Corre, RA de Boer, A Goel, T Johnson, CC Khor, C LluÃs-Ganella, J Luan, LP Lyytikäinen, IM Nolte, X Sim, S Sõber, PJ van der Most, N Verweij, JH Zhao, N Amin, E Boerwinkle, C Bouchard, A Dehghan, G Eiriksdottir, R Elosua, OH Franco, C Gieger, TB Harris, S Hercberg, A Hofman, AL James, AD Johnson, M Kähönen, KT Khaw, Z Kutalik, MG Larson, LJ Launer, G Li, J Liu, K Liu, AC Morrison, G Navis, RT Ong, GJ Papanicolau, BW Penninx, BM Psaty, LJ Raffel, OT Raitakari, K Rice, F Rivadeneira, LM Rose, S Sanna, RA Scott, DS Siscovick, RP Stolk, AG Uitterlinden, D Vaidya, MM van der Klauw, RS Vasan, EN Vithana, U Völker, H Völzke, H Watkins, TL Young, T Aung, M Bochud, M Farrall, CA Hartman, M Laan, EG Lakatta, T Lehtimäki, RJ Loos, G Lucas, P Meneton, LJ Palmer, R Rettig, H Snieder, ES Tai, YY Teo, P van der Harst, NJ Wareham, C Wijmenga, TY Wong, M Fornage, V Gudnason, D Levy, W Palmas, PM Ridker, JI Rotter, CM van Duijn, JC Witteman, A Chakravarti, DC Rao
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term diastolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Simino, G Shi, JC Bis, DI Chasman, GB Ehret, X Gu, X Guo, SJ Hwang, E Sijbrands, AV Smith, GC Verwoert, JL Bragg-Gresham, G Cadby, P Chen, CY Cheng, T Corre, RA de Boer, A Goel, T Johnson, CC Khor, C LluÃs-Ganella, J Luan, LP Lyytikäinen, IM Nolte, X Sim, S Sõber, PJ van der Most, N Verweij, JH Zhao, N Amin, E Boerwinkle, C Bouchard, A Dehghan, G Eiriksdottir, R Elosua, OH Franco, C Gieger, TB Harris, S Hercberg, A Hofman, AL James, AD Johnson, M Kähönen, KT Khaw, Z Kutalik, MG Larson, LJ Launer, G Li, J Liu, K Liu, AC Morrison, G Navis, RT Ong, GJ Papanicolau, BW Penninx, BM Psaty, LJ Raffel, OT Raitakari, K Rice, F Rivadeneira, LM Rose, S Sanna, RA Scott, DS Siscovick, RP Stolk, AG Uitterlinden, D Vaidya, MM van der Klauw, RS Vasan, EN Vithana, U Völker, H Völzke, H Watkins, TL Young, T Aung, M Bochud, M Farrall, CA Hartman, M Laan, EG Lakatta, T Lehtimäki, RJ Loos, G Lucas, P Meneton, LJ Palmer, R Rettig, H Snieder, ES Tai, YY Teo, P van der Harst, NJ Wareham, C Wijmenga, TY Wong, M Fornage, V Gudnason, D Levy, W Palmas, PM Ridker, JI Rotter, CM van Duijn, JC Witteman, A Chakravarti, DC Rao
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term systolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
N Kato, F Takeuchi, Y Tabara, TN Kelly, MJ Go, X Sim, WT Tay, CH Chen, Y Zhang, K Yamamoto, T Katsuya, M Yokota, YJ Kim, RT Ong, T Nabika, D Gu, LC Chang, Y Kokubo, W Huang, K Ohnaka, Y Yamori, E Nakashima, CE Jaquish, JY Lee, M Seielstad, M Isono, JE Hixson, YT Chen, T Miki, X Zhou, T Sugiyama, JP Jeon, JJ Liu, R Takayanagi, SS Kim, T Aung, YJ Sung, X Zhang, TY Wong, BG Han, S Kobayashi, T Ogihara, D Zhu, N Iwai, JY Wu, YY Teo, ES Tai, YS Cho, J He
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term diastolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
N Kato, F Takeuchi, Y Tabara, TN Kelly, MJ Go, X Sim, WT Tay, CH Chen, Y Zhang, K Yamamoto, T Katsuya, M Yokota, YJ Kim, RT Ong, T Nabika, D Gu, LC Chang, Y Kokubo, W Huang, K Ohnaka, Y Yamori, E Nakashima, CE Jaquish, JY Lee, M Seielstad, M Isono, JE Hixson, YT Chen, T Miki, X Zhou, T Sugiyama, JP Jeon, JJ Liu, R Takayanagi, SS Kim, T Aung, YJ Sung, X Zhang, TY Wong, BG Han, S Kobayashi, T Ogihara, D Zhu, N Iwai, JY Wu, YY Teo, ES Tai, YS Cho, J He
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hypertension. The EFO term hypertension was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
E Org, S Eyheramendy, P Juhanson, C Gieger, P Lichtner, N Klopp, G Veldre, A Döring, M Viigimaa, S Sõber, K Tomberg, G Eckstein, P Kelgo, T Rebane, S Shaw-Hawkins, P Howard, A Onipinla, RJ Dobson, SJ Newhouse, M Brown, A Dominiczak, J Connell, N Samani, M Farrall, MJ Caulfield, PB Munroe, T Illig, HE Wichmann, T Meitinger, M Laan
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hypertension. The EFO term hypertension was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Guo, B Tomlinson, T Chu, YJ Fang, H Gui, CS Tang, BH Yip, SS Cherny, YM Hur, PC Sham, TH Lam, NG Thomas
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Wang, JR O'Connell, PF McArdle, JB Wade, SE Dorff, SJ Shah, X Shi, L Pan, E Rampersaud, H Shen, JD Kim, AR Subramanya, NI Steinle, A Parsa, CC Ober, PA Welling, A Chakravarti, AB Weder, RS Cooper, BD Mitchell, AR Shuldiner, YP Chang
Activation of the mesolimbic dopamine reward pathway by acute ethanol produces reinforcement and changes in gene expression that appear to be crucial to the molecular basis for adaptive behaviors and addiction. The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after saline injection or acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 788 genes differentially expressed in control DBA/2J versus C57BL/6J mice and 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area. There were strikingly divergent patterns of ethanol-responsive gene expression in the two strains. Ethanol-responsive genes also showed clustering at discrete chromosomal regions, suggesting local chromatin effects in regulation. Ethanol-regulated genes were generally related to neuroplasticity, but regulation of discrete functional groups and pathways was brain region specific: glucocorticoid signaling, neurogenesis, and myelination in the prefrontal cortex; neuropeptide signaling and developmental genes, including factor Bdnf, in the nucleus accumbens; and retinoic acid signaling in the ventral tegmental area. Bioinformatics analysis identified several potential candidate genes for quantitative trait loci linked to ethanol behaviors, further supporting a role for expression profiling in identifying genes for complex traits. Brain region-specific changes in signaling and neuronal plasticity may be critical components in development of lasting ethanol behavioral phenotypes such as dependence, sensitization, and craving.
A list of the 307 genes found to be upregulated or downregulated by ethanol in PFC, VTA or NA of B6 or D2 mice. ID number represents cluster membership from Figure 4.
Authors:
Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Sikela JM, Williams RW, Miles MF
Striatum Gene Expression Correlates for NEPCOUNT45 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The NEPCOUNT45 measures Novel environment locomotion (activity beam breaks) 30-45 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for NEPCOUNT45 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The NEPCOUNT45 measures Novel environment locomotion (activity beam breaks) 30-45 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
GeneWeaver