Genome-wide association studies are conducted of two human cohorts, one group demonstrating nicotine dependence and another successfully quitting smoking. Study shows that some genetic components associated with the ability to quit overlap while many do not overlap. To perform the study, DNA samples were obtained from NIH volunteers and the allelic frequencies of the samples were analyzed using Affymetrix array analysis. This gene set comprises 290 genes associated with nicotine dependence.
Authors:
Drgon T, Montoya I, Johnson C, Liu QR, Walther D, Hamer D, Uhl GR
Hippocampus Gene Expression Correlates for ENTRIES_CLOSED measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The ENTRIES_CLOSED measures Number of entries into closed arms of plus maze under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for ENTRIES_OPEN measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The ENTRIES_OPEN measures Number of entries into open arms of plus maze under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for SHAKE measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The SHAKE measures Morphine - wet dog shakes under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for PCT_ENTRIES_CLOSED measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The PCT_ENTRIES_CLOSED measures Percentage of entries into closed arms of plus maze under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for PCT_ENTRIES_OPEN measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The PCT_ENTRIES_OPEN measures Percentage of entries into open arms of plus maze under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL for high-dose ethanol actions on Chr18 at D18Mit7 (73.95 Mbp , Build 37)
Description:
high-dose ethanol actions spans 48.95 - 98.95 Mbp (NCBI Build 37) on Chr18. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
QTL associated with angiogenesis due to FGF2 QTL 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (77065228)
QTL associated with bleomycin-induced pulmonary fibrosis 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (64987829)
QTL associated with circulating hormone level QTL 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (53317604)
QTL associated with cocaine induced activation 14. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (72180072)
QTL associated with duration of locomotor activity 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (76003023)
Authors:
Kelly MA, Low MJ, Phillips TJ, Wakeland EK, Yanagisawa M
QTL associated with experimental allergic encephalomyelitis susceptibility 25. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (81645252)
Authors:
Mazn Pelez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM
QTL associated with experimental severe malaria resistance. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56130259)
Authors:
Nagayasu E, Nagakura K, Akaki M, Tamiya G, Makino S, Nakano Y, Kimura M, Aikawa M
QTL associated with wound healing/regeneration 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (69831859)
Authors:
Heber-Katz E, Leferovich JM, Bedelbaeva K, Gourevitch D
QTL associated with heart failure modifier 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (60337702)
Authors:
Le Corvoisier P, Park HY, Carlson KM, Marchuk DA, Rockman HA
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