A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systemic lupus erythematosus. The EFO term systemic lupus erythematosus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
W Yang, H Tang, Y Zhang, X Tang, J Zhang, L Sun, J Yang, Y Cui, L Zhang, N Hirankarn, H Cheng, HF Pan, J Gao, TL Lee, Y Sheng, CS Lau, Y Li, TM Chan, X Yin, D Ying, Q Lu, AM Leung, X Zuo, X Chen, KL Tong, F Zhou, Q Diao, NK Tse, H Xie, CC Mok, F Hao, SN Wong, B Shi, KW Lee, Y Hui, MH Ho, B Liang, PP Lee, H Cui, Q Guo, BH Chung, X Pu, Q Liu, X Zhang, C Zhang, CY Chong, H Fang, RW Wong, Y Sun, MY Mok, XP Li, Y Avihingsanon, Z Zhai, P Rianthavorn, T Deekajorndej, K Suphapeetiporn, F Gao, V Shotelersuk, X Kang, SK Ying, L Zhang, WH Wong, D Zhu, SK Fung, F Zeng, WM Lai, CM Wong, IO Ng, MM Garcia-Barceló, SS Cherny, N Shen, PK Tam, PC Sham, DQ Ye, S Yang, X Zhang, YL Lau
The ability of tumors to evade destruction by the IMMUNE SYSTEM. Theories concerning possible mechanisms by which this takes place involve both cellular immunity (IMMUNITY, CELLULAR) and humoral immunity (ANTIBODY FORMATION), and also costimulatory pathways related to CD28 antigens (ANTIGENS, CD28) and CD80 antigens (ANTIGENS, CD80).
Generated by gene2mesh v. 1.1.1
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "CD80 biosynthetic process", which is defined as "The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.
Generated by gene2mesh v. 1.1.1
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Lobular breast cancer (menopausal hormone therapy interaction). The EFO term invasive lobular carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Primary biliary cirrhosis. The EFO term biliary liver cirrhosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
GF Mells, JA Floyd, KI Morley, HJ Cordell, CS Franklin, SY Shin, MA Heneghan, JM Neuberger, PT Donaldson, DB Day, SJ Ducker, AW Muriithi, EF Wheater, CJ Hammond, MF Dawwas, DE Jones, L Peltonen, GJ Alexander, RN Sandford, CA Anderson
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Primary biliary cirrhosis. The EFO term biliary liver cirrhosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
M Nakamura, N Nishida, M Kawashima, Y Aiba, A Tanaka, M Yasunami, H Nakamura, A Komori, M Nakamuta, M Zeniya, E Hashimoto, H Ohira, K Yamamoto, M Onji, S Kaneko, M Honda, S Yamagiwa, K Nakao, T Ichida, H Takikawa, M Seike, T Umemura, Y Ueno, S Sakisaka, K Kikuchi, H Ebinuma, N Yamashiki, S Tamura, Y Sugawara, A Mori, S Yagi, K Shirabe, A Taketomi, K Arai, K Monoe, T Ichikawa, M Taniai, Y Miyake, T Kumagi, M Abe, K Yoshizawa, S Joshita, S Shimoda, K Honda, H Takahashi, K Hirano, Y Takeyama, K Harada, K Migita, M Ito, H Yatsuhashi, N Fukushima, H Ota, T Komatsu, T Saoshiro, J Ishida, H Kouno, H Kouno, M Yagura, M Kobayashi, T Muro, N Masaki, K Hirata, Y Watanabe, Y Nakamura, M Shimada, N Hirashima, T Komeda, K Sugi, M Koga, K Ario, E Takesaki, Y Maehara, S Uemoto, N Kokudo, H Tsubouchi, M Mizokami, Y Nakanuma, K Tokunaga, H Ishibashi
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systemic lupus erythematosus. The EFO term systemic lupus erythematosus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Zhang, J Yang, J Zhang, L Sun, N Hirankarn, HF Pan, CS Lau, TM Chan, TL Lee, AM Leung, CC Mok, L Zhang, Y Wang, JJ Shen, SN Wong, KW Lee, MH Ho, PP Lee, BH Chung, CY Chong, RW Wong, MY Mok, WH Wong, KL Tong, NK Tse, XP Li, Y Avihingsanon, P Rianthavorn, T Deekajorndej, K Suphapeetiporn, V Shotelersuk, SK Ying, SK Fung, WM Lai, CM Wong, IO Ng, MM Garcia-Barcelo, SS Cherny, Y Cui, PC Sham, S Yang, DQ Ye, XJ Zhang, YL Lau, W Yang
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Vitiligo. The EFO term Vitiligo was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Jin, SA Birlea, PR Fain, TM Ferrara, S Ben, SL Riccardi, JB Cole, K Gowan, PJ Holland, DC Bennett, RM Luiten, A Wolkerstorfer, JP van der Veen, A Hartmann, S Eichner, G Schuler, N van Geel, J Lambert, EH Kemp, DJ Gawkrodger, AP Weetman, A Taïeb, T Jouary, K Ezzedine, MR Wallace, WT McCormack, M Picardo, G Leone, A Overbeck, NB Silverberg, RA Spritz
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Celiac disease. The EFO term celiac disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
PC Dubois, G Trynka, L Franke, KA Hunt, J Romanos, A Curtotti, A Zhernakova, GA Heap, R Adány, A Aromaa, MT Bardella, LH van den Berg, NA Bockett, EG de la Concha, B Dema, RS Fehrmann, M Fernández-Arquero, S Fiatal, E Grandone, PM Green, HJ Groen, R Gwilliam, RH Houwen, SE Hunt, K Kaukinen, D Kelleher, I Korponay-Szabo, K Kurppa, P MacMathuna, M Mäki, MC Mazzilli, OT McCann, ML Mearin, CA Mein, MM Mirza, V Mistry, B Mora, KI Morley, CJ Mulder, JA Murray, C Núñez, E Oosterom, RA Ophoff, I Polanco, L Peltonen, M Platteel, A Rybak, V Salomaa, JJ Schweizer, MP Sperandeo, GJ Tack, G Turner, JH Veldink, WH Verbeek, RK Weersma, VM Wolters, E Urcelay, B Cukrowska, L Greco, SL Neuhausen, R McManus, D Barisani, P Deloukas, JC Barrett, P Saavalainen, C Wijmenga, DA van Heel
Cerebellum Gene Expression Correlates for SHCOUNT60 measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The SHCOUNT60 measures Open Field - locomotion (activity beam breaks) 45-60 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for SHDIST60 measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The SHDIST60 measures Open field locomotion - Saline- (cm) 45-60 min under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for LM_BASELINE measured in BXD RI Females & Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The LM_BASELINE measures Baseline activity in fear conditioning apparatus under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_REAR_10_15 measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_REAR_10_15 measures Open Field - Total rears 10-15 minutes under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_REAR_15_20 measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_REAR_15_20 measures Open Field - Total rears 15-20 minutes under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for OF_REARS measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The OF_REARS measures Open Field - Total number of Rears under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for PTOSIS measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The PTOSIS measures Morphine - Severity of ptosis under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
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