List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cerebrospinal fluid levels of Alzheimer's disease-related proteins. The EFO term Alzheimers disease, Alzheimer's disease biomarker measurement, CCL2 measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JS Kauwe, MH Bailey, PG Ridge, R Perry, ME Wadsworth, KL Hoyt, LA Staley, CM Karch, O Harari, C Cruchaga, BJ Ainscough, K Bales, EH Pickering, S Bertelsen, AM Fagan, DM Holtzman, JC Morris, AM Goate
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Protein quantitative trait loci. The EFO term CCL2 measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
D Melzer, JR Perry, D Hernandez, AM Corsi, K Stevens, I Rafferty, F Lauretani, A Murray, JR Gibbs, G Paolisso, S Rafiq, J Simon-Sanchez, H Lango, S Scholz, MN Weedon, S Arepalli, N Rice, N Washecka, A Hurst, A Britton, W Henley, J van de Leemput, R Li, AB Newman, G Tranah, T Harris, V Panicker, C Dayan, A Bennett, MI McCarthy, A Ruokonen, MR Jarvelin, J Guralnik, S Bandinelli, TM Frayling, A Singleton, L Ferrucci
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Obesity-related traits. The EFO term CCL2 measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
AG Comuzzie, SA Cole, SL Laston, VS Voruganti, K Haack, RA Gibbs, NF Butte
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Select biomarker traits. The EFO term CCL2 measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
EJ Benjamin, J Dupuis, MG Larson, KL Lunetta, SL Booth, DR Govindaraju, S Kathiresan, JF Keaney, MJ Keyes, JP Lin, JB Meigs, SJ Robins, J Rong, R Schnabel, JA Vita, TJ Wang, PW Wilson, PA Wolf, RS Vasan
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Inflammatory biomarkers. The EFO term CCL2 measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
S Naitza, E Porcu, M Steri, DD Taub, A Mulas, X Xiao, J Strait, M Dei, S Lai, F Busonero, A Maschio, G Usala, M Zoledziewska, C Sidore, I Zara, M Pitzalis, A Loi, F Virdis, R Piras, F Deidda, MB Whalen, L Crisponi, A Concas, C Podda, S Uzzau, P Scheet, DL Longo, E Lakatta, GR Abecasis, A Cao, D Schlessinger, M Uda, S Sanna, F Cucca
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Monocyte chemoattractant protein-1. The EFO term CCL2 measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
VS Voruganti, S Laston, K Haack, NR Mehta, CW Smith, SA Cole, NF Butte, AG Comuzzie
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
Generated by gene2mesh v. 1.1.1
CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; BASOPHILS; and NK CELLS.
Generated by gene2mesh v. 1.1.1
The production of 12 out of 27 measured factors was induced by CEsHUT including IL-1β, TNF and IL-1Ra. In contrast to sIL-1Ra production, that of IL-1β and TNF was inhibited by HDL, corroborating previous results. In addition, CEsHUT induced monocytes to produce factors involved in their localization, survival and differentiation such as CCL5 (RANTES), CCL2 (MCP-1), interferon-γ (IFNγ), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage-CSF (M-CSF). The production of the latter was moderate and it was not affected by HDL.
Authors:
Gruaz L, Delucinge-Vivier C, Descombes P, Dayer JM, Burger D
Since HDL preparations may contain several particle subpopulations, we first ascertained that the inhibitory activity of the HDL preparation used in this study was due to apo A–I. As shown in Figure 1Figure 1, the inhibitory activity of HDL was reversed in a dose-dependent manner by antibodies to apo A–I. Antibodies to apo A–I alone did not affect IL-1β and TNF production by human monocytes. Similarly, they did not change CEsHUT-induced production of IL-1β or TNF in the absence of HDL.
Authors:
Gruaz L, Delucinge-Vivier C, Descombes P, Dayer JM, Burger D
Changes in mRNA abundance in human SH-SY5Y cells after 3 days of treatment with 100 mM ethanol. Entered by hand from Figure 1 as binary list. Referenced website of data is stale.
Authors:
Thibault C, Lai C, Wilke N, Duong B, Olive MF, Rahman S, Dong H, Hodge CW, Lockhart DJ, Miles MF
Chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.
Generated by gene2mesh v. 1.1.1
Genes significantly upregulated (p < 0.05) in bronchoalveolar lavage fluid (BALF) from SARS-CoV2 patients compared to healthy donors. Genes were taken from the BALF DEGs tab of Supplementary File 1 with value = "Up" in "Tag" column. Values are log2 fold change. Genes were entered as base Ensemble IDs. The following gene identifiers were not in GeneWeaver at the time of loading: ENSG00000285704, ENSG00000227081, ENSG00000264895, ENSG00000233762, ENSG00000277534, ENSG00000279166, ENSG00000264853, ENSG00000213197, ENSG00000287085, ENSG00000218175, ENSG00000279133, ENSG00000244313, ENSG00000229119, ENSG00000185641, ENSG00000259600, ENSG00000287613, ENSG00000242299, ENSG00000228655, ENSG00000279483, ENSG00000286545, ENSG00000236439, ENSG00000234287, ENSG00000251076, ENSG00000286830, ENSG00000253339, ENSG00000272211, ENSG00000244398, ENSG00000250461, ENSG00000185495, ENSG00000219023, ENSG00000228793, ENSG00000274173, ENSG00000279544, ENSG00000217130, ENSG00000231856, ENSG00000258752, ENSG00000178715, ENSG00000218426, ENSG00000227615, ENSG00000281383, ENSG00000214530.
Authors:
Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cerebrospinal fluid levels of Alzheimer's disease-related proteins. The EFO term matrix metalloproteinase measurement, Alzheimers disease, Alzheimer's disease biomarker measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JS Kauwe, MH Bailey, PG Ridge, R Perry, ME Wadsworth, KL Hoyt, LA Staley, CM Karch, O Harari, C Cruchaga, BJ Ainscough, K Bales, EH Pickering, S Bertelsen, AM Fagan, DM Holtzman, JC Morris, AM Goate
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cerebrospinal fluid levels of Alzheimer's disease-related proteins. The EFO term Alzheimers disease, interleukin-6 measurement, Alzheimer's disease biomarker measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JS Kauwe, MH Bailey, PG Ridge, R Perry, ME Wadsworth, KL Hoyt, LA Staley, CM Karch, O Harari, C Cruchaga, BJ Ainscough, K Bales, EH Pickering, S Bertelsen, AM Fagan, DM Holtzman, JC Morris, AM Goate
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cerebrospinal fluid levels of Alzheimer's disease-related proteins. The EFO term CCL4 measurement, Alzheimers disease, Alzheimer's disease biomarker measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JS Kauwe, MH Bailey, PG Ridge, R Perry, ME Wadsworth, KL Hoyt, LA Staley, CM Karch, O Harari, C Cruchaga, BJ Ainscough, K Bales, EH Pickering, S Bertelsen, AM Fagan, DM Holtzman, JC Morris, AM Goate
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cerebrospinal fluid levels of Alzheimer's disease-related proteins. The EFO term angiotensin-converting enzyme measurement, Alzheimers disease, Alzheimer's disease biomarker measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JS Kauwe, MH Bailey, PG Ridge, R Perry, ME Wadsworth, KL Hoyt, LA Staley, CM Karch, O Harari, C Cruchaga, BJ Ainscough, K Bales, EH Pickering, S Bertelsen, AM Fagan, DM Holtzman, JC Morris, AM Goate
Study analyzed 812 differentially expressed gene candidates from peripheral blood mononuclear cells (PBMC) from morphine and saline treated rats, and suggests similarities between the gene expression profile in PBMCs and in the brain of morphine-treated rats. This set contains the 79 genes implicated by this study to modulate expression during chronic morphine treatment.
Authors:
Desjardins S, Belkai E, Crete D, Cordonnier L, Scherrmann JM, Noble F, Marie-Claire C
Positional candidate genes for HOTPLATE_MEANOF2 in BXD RI Females & Males on Chr11
Description:
Position candidates for HOTPLATE_MEANOF2 measured in BXD RI Females & Males. HOTPLATE_MEANOF2 measures Thermal Nociception Hot Plate Avg of 2Trials under the domain Pain. The QTL found was a Suggestive QTL and spans 80 Mb to 90 Mb.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
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