An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Basal cell carcinoma. The EFO term basal cell carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
SN Stacey, H Helgason, SA Gudjonsson, G Thorleifsson, F Zink, A Sigurdsson, B Kehr, J Gudmundsson, P Sulem, B Sigurgeirsson, KR Benediktsdottir, K Thorisdottir, R Ragnarsson, V Fuentelsaz, C Corredera, Y Gilaberte, M Grasa, D Planelles, O Sanmartin, P Rudnai, E Gurzau, K Koppova, BA Nexø, A Tjønneland, K Overvad, JG Jonasson, L Tryggvadottir, H Johannsdottir, AM Kristinsdottir, H Stefansson, G Masson, OT Magnusson, BV Halldorsson, A Kong, T Rafnar, U Thorsteinsdottir, U Vogel, R Kumar, E Nagore, JI Mayordomo, DF Gudbjartsson, JH Olafsson, K Stefansson
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Chronic lymphocytic leukemia. The EFO term chronic lymphocytic leukemia was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
SI Berndt, CF Skibola, V Joseph, NJ Camp, A Nieters, Z Wang, W Cozen, A Monnereau, SS Wang, RS Kelly, Q Lan, LR Teras, N Chatterjee, CC Chung, M Yeager, AR Brooks-Wilson, P Hartge, MP Purdue, BM Birmann, BK Armstrong, P Cocco, Y Zhang, G Severi, A Zeleniuch-Jacquotte, C Lawrence, L Burdette, J Yuenger, A Hutchinson, KB Jacobs, TG Call, TD Shanafelt, AJ Novak, NE Kay, M Liebow, AH Wang, KE Smedby, HO Adami, M Melbye, B Glimelius, ET Chang, M Glenn, K Curtin, LA Cannon-Albright, B Jones, WR Diver, BK Link, GJ Weiner, L Conde, PM Bracci, J Riby, EA Holly, MT Smith, RD Jackson, LF Tinker, Y Benavente, N Becker, P Boffetta, P Brennan, L Foretova, M Maynadie, J McKay, A Staines, KG Rabe, SJ Achenbach, CM Vachon, LR Goldin, SS Strom, MC Lanasa, LG Spector, JF Leis, JM Cunningham, JB Weinberg, VA Morrison, NE Caporaso, AD Norman, MS Linet, AJ De Roos, LM Morton, RK Severson, E Riboli, P Vineis, R Kaaks, D Trichopoulos, G Masala, E Weiderpass, MD Chirlaque, RC Vermeulen, RC Travis, GG Giles, D Albanes, J Virtamo, S Weinstein, J Clavel, T Zheng, TR Holford, K Offit, A Zelenetz, RJ Klein, JJ Spinelli, KA Bertrand, F Laden, E Giovannucci, P Kraft, A Kricker, J Turner, CM Vajdic, MG Ennas, GM Ferri, L Miligi, L Liang, J Sampson, S Crouch, JH Park, KE North, A Cox, JA Snowden, J Wright, A Carracedo, C Lopez-Otin, S Bea, I Salaverria, D Martin-Garcia, E Campo, JF Fraumeni, S de Sanjose, H Hjalgrim, JR Cerhan, SJ Chanock, N Rothman, SL Slager
GNF2_CASP8
Neighborhood of CASP8
c4 - Computational genesets defined by mining large collections of cancer-oriented microarray data.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Melanoma. The EFO term melanoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JH Barrett, MM Iles, M Harland, JC Taylor, JF Aitken, PA Andresen, LA Akslen, BK Armstrong, MF Avril, E Azizi, B Bakker, W Bergman, G Bianchi-Scarrà , B Bressac-de Paillerets, D Calista, LA Cannon-Albright, E Corda, AE Cust, T Dębniak, D Duffy, AM Dunning, DF Easton, E Friedman, P Galan, P Ghiorzo, GG Giles, J Hansson, M Hocevar, V Höiom, JL Hopper, C Ingvar, B Janssen, MA Jenkins, G Jönsson, RF Kefford, G Landi, MT Landi, J Lang, J Lubiński, R Mackie, J Malvehy, NG Martin, A Molven, GW Montgomery, FA van Nieuwpoort, S Novakovic, H Olsson, L Pastorino, S Puig, JA Puig-Butille, J Randerson-Moor, H Snowden, R Tuominen, P Van Belle, N van der Stoep, DC Whiteman, D Zelenika, J Han, S Fang, JE Lee, Q Wei, GM Lathrop, EM Gillanders, KM Brown, AM Goldstein, PA Kanetsky, GJ Mann, S Macgregor, DE Elder, CI Amos, NK Hayward, NA Gruis, F Demenais, JA Bishop, DT Bishop
Cerebellum Gene Expression Correlates for C1HCOUNT45 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The C1HCOUNT45 measures Open Field locomotion 30-45 min post cocaine under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for C2HCOUNT45 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The C2HCOUNT45 measures Open Field locomotion (activity beam breaks) 30-45 min post 2nd cocaine under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for C2HCOUNT60 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The C2HCOUNT60 measures Open Field locomotion (activity beam breaks) 45-60 min post 2nd cocaine under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for C2HDIS60 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The C2HDIS60 measures Open Field Total34 horizontal distance (cm) 45-60 min post 2nd cocaine under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for C2VCOUNT60 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The C2VCOUNT60 measures Open Field rears 45-60 min post 2nd cocaine under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for LOC_CHCL_ACOUNT_3 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The LOC_CHCL_ACOUNT_3 measures Cocaine TOTAL locomotion (activity beam breaks) under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for OF_CENTER_DIST_PCT measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The OF_CENTER_DIST_PCT measures Open Field - Percentage of total distance traveled in center under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for OF_CENTER_TIME_PCT measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The OF_CENTER_TIME_PCT measures Open Field - Percentage center time under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for OF_TOT_PERIM_TIME_PCT measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The OF_TOT_PERIM_TIME_PCT measures Open Field-Total time in perimeter under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for SALINE_VCOUNT_2 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The SALINE_VCOUNT_2 measures Open Field TOTAL rears post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for SVCOUNT30 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The SVCOUNT30 measures Open Field rears 15-30 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for SVCOUNT45 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The SVCOUNT45 measures Open Field Rears 30-45 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for OF_TOT_PERIM_DIST_PCT measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The OF_TOT_PERIM_DIST_PCT measures Open Field -Total distance in the perimeter under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL for ethanol withdrawal on Chr1 at D1Mit122 (42.42 Mbp , Build 37)
Description:
ethanol withdrawal spans 17.42 - 67.42 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for body temperature on Chr1 at D1Ncvs75 (79.87 Mbp , Build 37)
Description:
METH responses for body temperature spans 54.87 - 104.87 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes associated with Homo sapiens that interact with the MeSH term 'kamebakaurin' (C047382). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Ribose' (D012266). Incorporates data from 298 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'formononetin' (C007768). Incorporates data from 20 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
GeneWeaver