A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Generated by gene2mesh v. 1.1.1
Human Phenotype Ontology (HPO) gene set. This set contains genes that have been annotated to the HPO term "Cervical C2/C3 vertebral fusion", which is defined as "Fusion of cervical vertebrae at C2 and C3, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development, leading to a short neck with a low hairline at the back of the head, and restricted mobility of the upper spine." This gene set was automatically constructed using annotation and ontology data provided by HPO and includes gene-phenotypes annotations from all HPO sources. The transitive closure of this term is taken into account using is_a relationships. For more information: The Human Phenotype Ontology Consortium (HPOC), http://human-phenotype-ontology.org This gene set was generated using the GeneWeaver HPO loader v. 0.1.5, HPO OBO v. hp/releases/2020-03-27, and HPO Genes to Phenotypes (all sources, all frequencies) v. 2020.05.06.
Authors:
S Köhler, SC Doelken, CJ Mungall, S Bauer, HV Firth, I Bailleul-Forestier, GC Black, DL Brown, M Brudno, J Campbell, DR FitzPatrick, JT Eppig, AP Jackson, K Freson, M Girdea, I Helbig, JA Hurst, J Jähn, LG Jackson, AM Kelly, DH Ledbetter, S Mansour, CL Martin, C Moss, A Mumford, WH Ouwehand, SM Park, ER Riggs, RH Scott, S Sisodiya, S Van Vooren, RJ Wapner, AO Wilkie, CF Wright, AT Vulto-van Silfhout, N de Leeuw, BB de Vries, NL Washingthon, CL Smith, M Westerfield, P Schofield, BJ Ruef, GV Gkoutos, M Haendel, D Smedley, SE Lewis, PN Robinson
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "propionyl-CoA C2-trimethyltridecanoyltransferase activity", which is defined as "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "tRNA wobble position uridine thiolation", which is defined as "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration. The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
W Chen, D Stambolian, AO Edwards, KE Branham, M Othman, J Jakobsdottir, N Tosakulwong, MA Pericak-Vance, PA Campochiaro, ML Klein, PL Tan, YP Conley, A Kanda, L Kopplin, Y Li, KJ Augustaitis, AJ Karoukis, WK Scott, A Agarwal, JL Kovach, SG Schwartz, EA Postel, M Brooks, KH Baratz, WL Brown, AJ Brucker, A Orlin, G Brown, A Ho, C Regillo, L Donoso, L Tian, B Kaderli, D Hadley, SA Hagstrom, NS Peachey, R Klein, BE Klein, N Gotoh, K Yamashiro, F Ferris Iii, JA Fagerness, R Reynolds, LA Farrer, IK Kim, JW Miller, M CortĂłn, A Carracedo, M Sanchez-Salorio, EW Pugh, KF Doheny, M Brion, MM Deangelis, DE Weeks, DJ Zack, EY Chew, JR Heckenlively, N Yoshimura, SK Iyengar, PJ Francis, N Katsanis, JM Seddon, JL Haines, MB Gorin, GR Abecasis, A Swaroop
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration. The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Yu, TR Bhangale, J Fagerness, S Ripke, G Thorleifsson, PL Tan, EH Souied, AJ Richardson, JE Merriam, GH Buitendijk, R Reynolds, S Raychaudhuri, KA Chin, L Sobrin, E Evangelou, PH Lee, AY Lee, N Leveziel, DJ Zack, B Campochiaro, P Campochiaro, RT Smith, GR Barile, RH Guymer, R Hogg, U Chakravarthy, LD Robman, O Gustafsson, H Sigurdsson, W Ortmann, TW Behrens, K Stefansson, AG Uitterlinden, CM van Duijn, JR Vingerling, CC Klaver, R Allikmets, MA Brantley, PN Baird, N Katsanis, U Thorsteinsdottir, JP Ioannidis, MJ Daly, RR Graham, JM Seddon
Genes associated with Homo sapiens that interact with the MeSH term '17-amino-17-demethoxygeldanamycin -C2-galactose' (C515135). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Generated by gene2mesh v. 1.1.1
Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.
Generated by gene2mesh v. 1.1.1
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "ethylene metabolic process", which is defined as "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
545 differentially expressed genes in Cluster 2 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S6. From table legend: "This analysis was performed (per cluster) without separating male and female samples. Entries that are greyed out have p_val_adj < 0.05. “Avg_diff” is conditionally formatted to indicate up- and down-regulation of expression in cocaine compared to sucrose (red: up-regulated, green: down-regulated and yellow: no difference). The “Names” sheet at the end of file was used to convert GeneIDs to FlybaseIDs and Gene Symbols. p_val: raw p-value from the differential expression analysis for the given gene in the corresponding cluster. avg_diff: the difference in the loge transformed average expression of the given gene in the corresponding cluster (sheet) between the two conditions (cocaine compared to sucrose). Values above 0 indicate up-regulation of expression due to cocaine, and likewise, values below zero represent downregulation of expression due to cocaine. pct.1: percentage of cells expressing the gene in the cluster from the first condition (cocaine). pct.2: percentage of cells expressing the gene in the cluster from the second condition (sucrose). p_val_adj: Benjamini-Hochberg FDR adjusted p-value." Values presented are p-adjusted values. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
566 differentially expressed genes in Cluster 2 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S7. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
536 differentially expressed genes in Cluster 2 in the female Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S8. Data available at GEO with accession number GSE152495.GSE116484.A7
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
536 differentially expressed genes in Cluster 2 in the female Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S8. Data available at GEO with accession number GSE152495.GSE116484.A7
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration (GA). The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
L Sobrin, S Ripke, Y Yu, J Fagerness, TR Bhangale, PL Tan, EH Souied, GH Buitendijk, JE Merriam, AJ Richardson, S Raychaudhuri, R Reynolds, KA Chin, AY Lee, N Leveziel, DJ Zack, P Campochiaro, RT Smith, GR Barile, RE Hogg, U Chakravarthy, TW Behrens, AG Uitterlinden, CM van Duijn, JR Vingerling, MA Brantley, PN Baird, CC Klaver, R Allikmets, N Katsanis, RR Graham, JP Ioannidis, MJ Daly, JM Seddon
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration. The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration. The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
LJ Kopplin, RP Igo, Y Wang, TA Sivakumaran, SA Hagstrom, NS Peachey, PJ Francis, ML Klein, JP SanGiovanni, EY Chew, GJ Pauer, GM Sturgill, T Joshi, L Tian, Q Xi, AK Henning, KE Lee, R Klein, BE Klein, SK Iyengar
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "mitochondrial tRNA wobble position uridine thiolation", which is defined as "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Warning: You are not signed in. Adding these genesets to a project will create a guest account for you.
Guest accounts are temporary, and will be removed within 24 hours of creation. Guest accounts can be registered as full accounts, but you cannot associate a guest account with an existing account.
If you already have an account, you should sign into that account before proceeding.