List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Glaucoma (high intraocular pressure). The EFO term open-angle glaucoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JN Bailey, SJ Loomis, JH Kang, RR Allingham, P Gharahkhani, CC Khor, KP Burdon, H Aschard, DI Chasman, RP Igo, PG Hysi, CA Glastonbury, A Ashley-Koch, M Brilliant, AA Brown, DL Budenz, A Buil, CY Cheng, H Choi, WG Christen, G Curhan, I De Vivo, JH Fingert, PJ Foster, C Fuchs, D Gaasterland, T Gaasterland, AW Hewitt, F Hu, DJ Hunter, AP Khawaja, RK Lee, Z Li, PR Lichter, DA Mackey, P McGuffin, P Mitchell, SE Moroi, SA Perera, KW Pepper, Q Qi, T Realini, JE Richards, PM Ridker, E Rimm, R Ritch, M Ritchie, JS Schuman, WK Scott, K Singh, AJ Sit, YE Song, RM Tamimi, F Topouzis, AC Viswanathan, SS Verma, D Vollrath, JJ Wang, N Weisschuh, B Wissinger, G Wollstein, TY Wong, BL Yaspan, DJ Zack, K Zhang, EN Study, RN Weinreb, MA Pericak-Vance, K Small, CJ Hammond, T Aung, Y Liu, EN Vithana, S MacGregor, JE Craig, P Kraft, G Howell, MA Hauser, LR Pasquale, JL Haines, JL Wiggs
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Glaucoma (low intraocular pressure). The EFO term low tension glaucoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JN Bailey, SJ Loomis, JH Kang, RR Allingham, P Gharahkhani, CC Khor, KP Burdon, H Aschard, DI Chasman, RP Igo, PG Hysi, CA Glastonbury, A Ashley-Koch, M Brilliant, AA Brown, DL Budenz, A Buil, CY Cheng, H Choi, WG Christen, G Curhan, I De Vivo, JH Fingert, PJ Foster, C Fuchs, D Gaasterland, T Gaasterland, AW Hewitt, F Hu, DJ Hunter, AP Khawaja, RK Lee, Z Li, PR Lichter, DA Mackey, P McGuffin, P Mitchell, SE Moroi, SA Perera, KW Pepper, Q Qi, T Realini, JE Richards, PM Ridker, E Rimm, R Ritch, M Ritchie, JS Schuman, WK Scott, K Singh, AJ Sit, YE Song, RM Tamimi, F Topouzis, AC Viswanathan, SS Verma, D Vollrath, JJ Wang, N Weisschuh, B Wissinger, G Wollstein, TY Wong, BL Yaspan, DJ Zack, K Zhang, EN Study, RN Weinreb, MA Pericak-Vance, K Small, CJ Hammond, T Aung, Y Liu, EN Vithana, S MacGregor, JE Craig, P Kraft, G Howell, MA Hauser, LR Pasquale, JL Haines, JL Wiggs
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Urate levels. The EFO term urate measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Köttgen, E Albrecht, A Teumer, V Vitart, J Krumsiek, C Hundertmark, G Pistis, D Ruggiero, CM O'Seaghdha, T Haller, Q Yang, T Tanaka, AD Johnson, Z Kutalik, AV Smith, J Shi, M Struchalin, RP Middelberg, MJ Brown, AL Gaffo, N Pirastu, G Li, C Hayward, T Zemunik, J Huffman, L Yengo, JH Zhao, A Demirkan, MF Feitosa, X Liu, G Malerba, LM Lopez, P van der Harst, X Li, ME Kleber, AA Hicks, IM Nolte, A Johansson, F Murgia, SH Wild, SJ Bakker, JF Peden, A Dehghan, M Steri, A Tenesa, V Lagou, P Salo, M Mangino, LM Rose, T Lehtimäki, OM Woodward, Y Okada, A Tin, C Müller, C Oldmeadow, M Putku, D Czamara, P Kraft, L Frogheri, GA Thun, A Grotevendt, GK Gislason, TB Harris, LJ Launer, P McArdle, AR Shuldiner, E Boerwinkle, J Coresh, H Schmidt, M Schallert, NG Martin, GW Montgomery, M Kubo, Y Nakamura, T Tanaka, PB Munroe, NJ Samani, DR Jacobs, K Liu, P D'Adamo, S Ulivi, JI Rotter, BM Psaty, P Vollenweider, G Waeber, S Campbell, O Devuyst, P Navarro, I Kolcic, N Hastie, B Balkau, P Froguel, T Esko, A Salumets, KT Khaw, C Langenberg, NJ Wareham, A Isaacs, A Kraja, Q Zhang, PS Wild, RJ Scott, EG Holliday, E Org, M Viigimaa, S Bandinelli, JE Metter, A Lupo, E Trabetti, R Sorice, A Döring, E Lattka, K Strauch, F Theis, M Waldenberger, HE Wichmann, G Davies, AJ Gow, M Bruinenberg, RP Stolk, JS Kooner, W Zhang, BR Winkelmann, BO Boehm, S Lucae, BW Penninx, JH Smit, G Curhan, P Mudgal, RM Plenge, L Portas, I Persico, M Kirin, JF Wilson, I Mateo Leach, WH van Gilst, A Goel, H Ongen, A Hofman, F Rivadeneira, AG Uitterlinden, M Imboden, A von Eckardstein, F Cucca, R Nagaraja, MG Piras, M Nauck, C Schurmann, K Budde, F Ernst, SM Farrington, E Theodoratou, I Prokopenko, M Stumvoll, A Jula, M Perola, V Salomaa, SY Shin, TD Spector, C Sala, PM Ridker, M Kähönen, J Viikari, C Hengstenberg, CP Nelson, JF Meschia, MA Nalls, P Sharma, AB Singleton, N Kamatani, T Zeller, M Burnier, J Attia, M Laan, N Klopp, HL Hillege, S Kloiber, H Choi, M Pirastu, S Tore, NM Probst-Hensch, H Völzke, V Gudnason, A Parsa, R Schmidt, JB Whitfield, M Fornage, P Gasparini, DS Siscovick, O Polašek, H Campbell, I Rudan, N Bouatia-Naji, A Metspalu, RJ Loos, CM van Duijn, IB Borecki, L Ferrucci, G Gambaro, IJ Deary, BH Wolffenbuttel, JC Chambers, W März, PP Pramstaller, H Snieder, U Gyllensten, AF Wright, G Navis, H Watkins, JC Witteman, S Sanna, S Schipf, MG Dunlop, A Tönjes, S Ripatti, N Soranzo, D Toniolo, DI Chasman, O Raitakari, WH Kao, M Ciullo, CS Fox, M Caulfield, M Bochud, C Gieger
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Peripheral artery disease. The EFO term peripheral arterial disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
IJ Kullo, K Shameer, H Jouni, TG Lesnick, J Pathak, CG Chute, M de Andrade
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Retinal vascular caliber. The EFO term eye measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
MK Ikram, X Sim, S Xueling, RA Jensen, MF Cotch, AW Hewitt, MA Ikram, JJ Wang, R Klein, BE Klein, MM Breteler, N Cheung, G Liew, P Mitchell, AG Uitterlinden, F Rivadeneira, A Hofman, PT de Jong, CM van Duijn, L Kao, CY Cheng, AV Smith, NL Glazer, T Lumley, B McKnight, BM Psaty, F Jonasson, G Eiriksdottir, T Aspelund, TB Harris, LJ Launer, KD Taylor, X Li, SK Iyengar, Q Xi, TA Sivakumaran, DA Mackey, S Macgregor, NG Martin, TL Young, JC Bis, KL Wiggins, SR Heckbert, CJ Hammond, T Andrew, S Fahy, J Attia, EG Holliday, RJ Scott, FM Islam, JI Rotter, AK McAuley, E Boerwinkle, ES Tai, V Gudnason, DS Siscovick, JR Vingerling, TY Wong
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Thyroid peroxidase antibody levels. The EFO term thyroid peroxidase antibody measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
M Medici, E Porcu, G Pistis, A Teumer, SJ Brown, RA Jensen, R Rawal, GL Roef, TS Plantinga, SH Vermeulen, J Lahti, MJ Simmonds, LL Husemoen, RM Freathy, BM Shields, D Pietzner, R Nagy, L Broer, L Chaker, TI Korevaar, MG Plia, C Sala, U Völker, JB Richards, FC Sweep, C Gieger, T Corre, E Kajantie, B Thuesen, YE Taes, WE Visser, AT Hattersley, J Kratzsch, A Hamilton, W Li, G Homuth, M Lobina, S Mariotti, N Soranzo, M Cocca, M Nauck, C Spielhagen, A Ross, A Arnold, M van de Bunt, S Liyanarachchi, M Heier, HJ Grabe, C Masciullo, TE Galesloot, EM Lim, E Reischl, PJ Leedman, S Lai, A Delitala, AP Bremner, DI Philips, JP Beilby, A Mulas, M Vocale, G Abecasis, T Forsen, A James, E Widen, J Hui, H Prokisch, EE Rietzschel, A Palotie, P Feddema, SJ Fletcher, K Schramm, JI Rotter, A Kluttig, D Radke, M Traglia, GL Surdulescu, H He, JA Franklyn, D Tiller, B Vaidya, T de Meyer, T Jørgensen, JG Eriksson, PC O'Leary, E Wichmann, AR Hermus, BM Psaty, T Ittermann, A Hofman, E Bosi, D Schlessinger, H Wallaschofski, N Pirastu, YS Aulchenko, A de la Chapelle, RT Netea-Maier, SC Gough, H Meyer Zu Schwabedissen, TM Frayling, JM Kaufman, A Linneberg, K Räikkönen, JW Smit, LA Kiemeney, F Rivadeneira, AG Uitterlinden, JP Walsh, C Meisinger, M den Heijer, TJ Visser, TD Spector, SG Wilson, H Völzke, A Cappola, D Toniolo, S Sanna, S Naitza, RP Peeters
GWAS: cystatin C measurement, chronic kidney disease
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Chronic kidney disease. The EFO term cystatin C measurement, chronic kidney disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Köttgen, C Pattaro, CA Böger, C Fuchsberger, M Olden, NL Glazer, A Parsa, X Gao, Q Yang, AV Smith, JR O'Connell, M Li, H Schmidt, T Tanaka, A Isaacs, S Ketkar, SJ Hwang, AD Johnson, A Dehghan, A Teumer, G Paré, EJ Atkinson, T Zeller, K Lohman, MC Cornelis, NM Probst-Hensch, F Kronenberg, A Tönjes, C Hayward, T Aspelund, G Eiriksdottir, LJ Launer, TB Harris, E Rampersaud, BD Mitchell, DE Arking, E Boerwinkle, M Struchalin, M Cavalieri, A Singleton, F Giallauria, J Metter, IH de Boer, T Haritunians, T Lumley, D Siscovick, BM Psaty, MC Zillikens, BA Oostra, M Feitosa, M Province, M de Andrade, ST Turner, A Schillert, A Ziegler, PS Wild, RB Schnabel, S Wilde, TF Munzel, TS Leak, T Illig, N Klopp, C Meisinger, HE Wichmann, W Koenig, L Zgaga, T Zemunik, I Kolcic, C Minelli, FB Hu, A Johansson, W Igl, G Zaboli, SH Wild, AF Wright, H Campbell, D Ellinghaus, S Schreiber, YS Aulchenko, JF Felix, F Rivadeneira, AG Uitterlinden, A Hofman, M Imboden, D Nitsch, A Brandstätter, B Kollerits, L Kedenko, R Mägi, M Stumvoll, P Kovacs, M Boban, S Campbell, K Endlich, H Völzke, HK Kroemer, M Nauck, U Völker, O Polasek, V Vitart, S Badola, AN Parker, PM Ridker, SL Kardia, S Blankenberg, Y Liu, GC Curhan, A Franke, T Rochat, B Paulweber, I Prokopenko, W Wang, V Gudnason, AR Shuldiner, J Coresh, R Schmidt, L Ferrucci, MG Shlipak, CM van Duijn, I Borecki, BK Krämer, I Rudan, U Gyllensten, JF Wilson, JC Witteman, PP Pramstaller, R Rettig, N Hastie, DI Chasman, WH Kao, IM Heid, CS Fox
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Cerebellum differential expression analysis of genotype by time effects in Pax6 mice and controls. This set contains genes for which there is an additive effect of the mutation and linear increase in both mutant and wild types through time.
Hippocampus Gene Expression Correlates for TAILCLIP_LAT_SEC measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The TAILCLIP_LAT_SEC measures Mechanical Nociception - Tail Clip Test under the domain Pain. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for TAILCLIP_LAT_SEC measured in BXD RI Females & Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The TAILCLIP_LAT_SEC measures Mechanical Nociception - Tail Clip Test under the domain Pain. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_PCT_PPI_70 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_PCT_PPI_70 measures Prepulse inhibition at 70db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_PCT_PPI_80 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_PCT_PPI_80 measures Prepulse inhibition at 80db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for ST_PCT_PPI_85 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ST_PCT_PPI_85 measures Prepulse inhibition at 85db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_PCT_STARTLE_70 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_PCT_STARTLE_70 measures Acoustic Startle Response Percentage of maximum startle response at 70 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_PCT_STARTLE_80 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_PCT_STARTLE_80 measures Acoustic Startle Response Percentage of maximum startle response at 80 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for ST_PCT_STARTLE_85 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ST_PCT_STARTLE_85 measures Acoustic Startle Response Percentage of maximum response at 85 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for ADRE_RIGHT_WT measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ADRE_RIGHT_WT measures Right adrenal weight under the domain Adrenals. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for COCA_TIME_COND_CHG measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The COCA_TIME_COND_CHG measures Cocaine CPP - difference in time spent relative to baseline drug exposure under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for OF_REAR_5_10 measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The OF_REAR_5_10 measures Open Field - Total rears 5-10 minutes under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
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