QTL spans- 118.3-168.3 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Ethanol consumption in mice was analyzed in selectively breed mice derived from an F2 population of intercrossed (C57BL/6J x DBA/2J)F1 mice. Whereas C57BL/6J are high consumers of alcohol and DBA/2J are low consumers. The concentration of ethanol used was 10%. With low preference mice and high preference mice mated for a maximum of 4 generations. In generation 4 of the Low selected line a significant QTL was observed and associated with D3Mit17. Authors suggest Adh1 may be a candidate gene.
cocaine related behavior 4 (Cocrb4) spans 120.266777 - 170.266777 Mbp (NCBI Build 37) on Chr 3. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for cocaine related behavior on Chr3 at D3Ncvs49 (145.27 Mbp , Build 37)
Description:
cocaine related behavior spans 120.27 - 170.27 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for body temperature on Chr3 at P40-rs4 (154.89 Mbp , Build 37)
Description:
METH responses for body temperature spans 129.89 - 179.89 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Rats in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed were measured over 2 days. Additive QTL. Variance 18, p-value 0.00022, LOD 4.1 Peak Marker: D2Rat118 spans 192489056-237489056 Strains were WKY, HEP.
Authors:
Terenina-Rigaldie E, Moisan MP, Colas A, Beaug F, Shah KV, Jones BC, Mormde P
Ethanol Induced Hypothermia Chr# 3 rs3710548 (145932289) with right flanking marker rs3719390 (85222358) and left marker rs30801216 (156802752). This was mapped in 300 + (b6x129)F2 mice.
loss of righting reflex assay. 155,101,972 - 247,295,816 involved strains HAS.LAS-(D2Rat38-D2Rat69). intercross allele responsible: LAS allele was dominant inducing agent: intraperitoneal administration of alcohol 2.25 g/kg measurement method: after alcohol administration, animals were placed on their back and the time at when they no longer right themselves was recorded; the lapse time at which they could right themselves was taken as loss of righting reflex (LORR) Likelihood Ratio: 16.3 software package used: Map Manager QTX duration of loss of righting reflex was less in female
Authors:
Radcliffe RA, Bludeau P, Asperi W, Fay T, Deng XS, Erwin VG, Deitrich RA
mean blood ethanol concentration at regain of righting reflex mapping to Chr 2. 222,136,025 - 258,207,540. measurement method: mean blood ethanol concentration from two 40 microliter retro-orbital blood samples number of animals used: 1201 F2 rats; 598 males, 603 females software used: SPSS version 16.0; L/QTL for QTL mapping
Authors:
Radcliffe RA, Erwin VG, Bludeau P, Deng X, Fay T, Floyd KL, Deitrich RA
QTL associated with activity response to ethanol 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147806689)
Authors:
Malmanger B, Lawler M, Coulombe S, Murray R, Cooper S, Polyakov Y, Belknap J, Hitzemann R
QTL associated with "alcohol preference locus 3, male specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147694263)
QTL associated with atherosclerotic lesion area 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147806703)
QTL associated with atherosclerotic lesion area 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (115533310)
QTL associated with bone response to mechanical loading 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (143227451)
QTL associated with cytokine deficiency colitis susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (126744151)
QTL associated with P. chabaudi malaria resistance QTL 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (127399252)
Authors:
Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, Foote S, Gros P
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